Jennifer R. Shingleton

Genomic landscape of mycosis fungoides

Fadzai Chinyengetere, Leonardo P. A. Biral, Veronica S. Russell, Kikkeri N. Naresh et autres

Abstract Introduction: Cutaneous T-cell lymphomas (CTCLs) are a rare, clinically heterogenous group of extranodal lymphomas that arise from mature skin-resident T cells. Mycosis fungoides (MF) is the most common primary CTCL, accounting for >50% of all cases. MF occurs on a spectrum …

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Identifying biological differences between two clinical risk groups of cutaneous CD30+ T cell lymphoproliferative disorders

Leonardo P. A. Biral, Veronica S. Russell, Chee Leong Cheng, Andrew Evans et autres

Abstract Background Cutaneous CD30+ T cell lymphoproliferative disorders (CD30+ T LPD) comprise a group of diseases that share overlapping dermato-histopathologic features with variable clinical outcomes. These diagnoses include lymphomatoid papulosis (LYP), primary cutaneous anaplastic large cell lymphoma (cALCL), CD30+ mycosis fungoides (MF), …

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Clinical Validation of Duoseq, a Novel Assay for Clinical DNA and RNA Sequencing

Elizabeth Thacker, Lanie E. Happ, Magdalena Czader, Lin Wang et autres

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Abstract 3910: The Atlas of Blood Cancer Genomes: A resource for therapeutic and biomarker development

Jennifer R. Shingleton, Raju K. Pillai, Sarah Lynn Ondrejka, Govind Bhagat et autres

Abstract Developing a novel cancer therapy is an expensive, time-consuming, high-risk endeavor that involves identifying a molecular target as well as target indications. This process could be accelerated by a comprehensive interrogation of driver variants and gene expression profiles across cancer types. …

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Analytical and Clinical Validation of Duoseq, a Novel Assay for Rapid, on-Site Clinical DNA and RNA Sequencing of Hematologic Malignancies

Eric D. Hsi, Magdalena Czader, Brian Thomas Hill, Elizabeth Thacker et autres

Introduction: Next generation sequencing (NGS) has become a critical component of the workup of malignancies. NGS can provide important diagnostic information including mutations, chromosomal copy number alterations and translocations (from DNAseq) as well as gene expression and fusions (from RNAseq). Incorporation of …

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Identifying Molecular Drivers of Lymphomagenesis

Jennifer R. Shingleton, Sandeep S. Davé

Genomic technologies have revolutionized the study of molecular drivers of lymphoma development. These studies have uncovered common as well as disease-specific lymphoma drivers that represent promising therapeutic targets; however, significant barriers to clinical translation still remain. In this chapter, we review the …

Enteropathy‐Associated and Monomorphic Epitheliotropic Intestinal T‐cell Lymphomas

Craig R. Soderquist, Jennifer R. Shingleton, Sandeep S. Davé, Govind Bhagat

This chapter describes the clinical, pathological, and genetic characteristics of enteropathy-associated T-cell lymphoma (EATL), monomorphic epitheliotropic intestinal T-cell lymphoma, and refractory celiac disease (RCD), a rare lymphoproliferative disorder that is a precursor to a subset of EATLs. It discusses current and emerging …

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Non-Hodgkin Lymphomas: Malignancies Arising from Mature B Cells

Jennifer R. Shingleton, Jie Wang, Carolyn Baloh, Tushar Dave et autres

Non-Hodgkin lymphomas (NHLs) are a diverse group of entities, both clinically and molecularly. Here, we review the evolution of classification schemes in B-cell lymphoma, noting the now standard WHO classification system that is based on immune cell-of-origin and molecular phenotypes. We review …

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Polatuzumab Vedotin: Honing in on Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Jennifer R. Shingleton, Sandeep S. Davé

Article Tools UNDERSTANDING THE PATHWAY Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES Polatuzumab Vedotin in Relapsed or Refractory Diffuse Large B-Cell Lymphoma. November 06, 2019 ARTICLE CITATION DOI: 10.1200/JCO.19.02587 Journal of Clinical …

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The whole-genome landscape of Burkitt lymphoma subtypes

Razvan Panea, Cassandra Love, Jennifer R. Shingleton, Anupama Reddy et autres

Burkitt lymphoma (BL) is an aggressive, MYC-driven lymphoma comprising 3 distinct clinical subtypes: sporadic BLs that occur worldwide, endemic BLs that occur predominantly in sub-Saharan Africa, and immunodeficiency-associated BLs that occur primarily in the setting of HIV. In this study, we comprehensively …

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TET2 Deficiency Sets the Stage for B-cell Lymphoma

Jennifer R. Shingleton, Sandeep S. Davé

Abstract Summary: TET2 is a well-established tumor suppressor in the context of myeloid malignancies, but its role in lymphoma development has been less clear. In this issue of Cancer Discovery, Dominguez and colleagues report that TET2 function is critical for germinal center …

Genetic convergence of rare lymphomas

Jennifer R. Shingleton, Sandeep S. Davé

PURPOSE OF REVIEW: We review the genetic foundations of different rare lymphomas to examine their shared origins. These data indicate the potential application of genomics to improve the diagnosis and treatment of these rare diseases. RECENT FINDINGS: Next generation sequencing technologies have …

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