Cassandra Love

Genomic landscape of mycosis fungoides

Fadzai Chinyengetere, Leonardo P. A. Biral, Veronica S. Russell, Kikkeri N. Naresh et autres

Abstract Introduction: Cutaneous T-cell lymphomas (CTCLs) are a rare, clinically heterogenous group of extranodal lymphomas that arise from mature skin-resident T cells. Mycosis fungoides (MF) is the most common primary CTCL, accounting for >50% of all cases. MF occurs on a spectrum …

us, gb, Afrique du Sud, dk, fi, sg, qa, Égypte (code pays fourni par la source)

Identifying biological differences between two clinical risk groups of cutaneous CD30+ T cell lymphoproliferative disorders

Leonardo P. A. Biral, Veronica S. Russell, Chee Leong Cheng, Andrew Evans et autres

Abstract Background Cutaneous CD30+ T cell lymphoproliferative disorders (CD30+ T LPD) comprise a group of diseases that share overlapping dermato-histopathologic features with variable clinical outcomes. These diagnoses include lymphomatoid papulosis (LYP), primary cutaneous anaplastic large cell lymphoma (cALCL), CD30+ mycosis fungoides (MF), …

us, gb, sg, fi (code pays fourni par la source)

Novel immune gene expression signature risk-stratifies Mantle Cell Lymphoma outcomes independent of TP53 status

Jean Louise Koff, Veronica S. Russell, Rachel Kositsky, David L. Jaye et autres

Abstract Background: The prognostic impact of specific genomic changes in mantle cell lymphoma (MCL) is not well characterized beyond altered TP53, which is recognized as a high-risk marker and commonly assessed at diagnosis, and the “proliferation signature” developed using gene expression in …

us, gb, fi, dk, Afrique du Sud, hk, sg, ca, qa (code pays fourni par la source)

Clinical Validation of Duoseq, a Novel Assay for Clinical DNA and RNA Sequencing

Elizabeth Thacker, Lanie E. Happ, Magdalena Czader, Lin Wang et autres

us (code pays fourni par la source)

Molecular and Clinical Determinants of CAR-T Therapy Response in DLBCL

Devang Thakkar, Brian Thomas Hill, Rachel Kositsky, Shari Tian et autres

Introduction: Diffuse large B-cell lymphoma (DLBCL) is one of the most common forms of blood cancer worldwide. Outcomes for patients with relapsed or refractory (r/r) DLBCL have remained dismal. Chimeric antigen receptor (CAR) T-cell therapy targeting the B-cell surface marker CD19 has …

us, fr (code pays fourni par la source)

Unraveling the Transcriptional Landscape of Nodular Lymphocyte-Predominant Hodgkin Lymphoma and T-Cell/Histiocyte Rich Large B-Cell Lymphoma: Impact of Tumor Microenvironment and Checkpoint Gene Expression

Ilja Kalashnikov, Veronica S. Russell, Panu E. Kovanen, Johannes Dunkel et autres

Introduction: Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare B-cell malignancy with a paucity of malignant cells embedded in a diverse tumor microenvironment (TME). The histological composition of the TME is known to influence outcomes, with nodular B-cell rich TME (classical histology, …

fi, us, dk, sg, cn (code pays fourni par la source)

Analytical and Clinical Validation of Duoseq, a Novel Assay for Rapid, on-Site Clinical DNA and RNA Sequencing of Hematologic Malignancies

Eric D. Hsi, Magdalena Czader, Brian Thomas Hill, Elizabeth Thacker et autres

Introduction: Next generation sequencing (NGS) has become a critical component of the workup of malignancies. NGS can provide important diagnostic information including mutations, chromosomal copy number alterations and translocations (from DNAseq) as well as gene expression and fusions (from RNAseq). Incorporation of …

us (code pays fourni par la source)

Supplementary Methods, Figures S1 - S9 from The Genetic Basis of Hepatosplenic T-cell Lymphoma

Matthew Stuart McKinney, Andrea B. Moffitt, Philippe Gaulard, Marion Travert et autres

Supplementary Figure S1. Sanger sequencing chromatograms. Supplementary Figure S2. Cancer cell fraction for driver genes. Supplementary Figure S3. Ideogram with chromosome 7 alterations. Supplementary Figure S4. Examples of Exome Copy Number. Supplementary Figure S5. Exploratory Kaplan-Meier plots for clinical covariates. Supplementary Figure …

Supplementary Tables S1 - S10 from The Genetic Basis of Hepatosplenic T-cell Lymphoma

Matthew Stuart McKinney, Andrea B. Moffitt, Philippe Gaulard, Marion Travert et autres

Supplementary Table S1. Sanger validated variants. Supplementary Table S2. Mutations in HSTL driver genes. Supplementary Table S3. Other mutations identified by exome sequencing. Supplementary Table S4. Copy number of HSTL patients and cell lines. Supplementary Table S5. Clinical and pathological characteristics of …

Supplementary Methods, Figures S1 - S9 from The Genetic Basis of Hepatosplenic T-cell Lymphoma

Matthew Stuart McKinney, Andrea B. Moffitt, Philippe Gaulard, Marion Travert et autres

Supplementary Figure S1. Sanger sequencing chromatograms. Supplementary Figure S2. Cancer cell fraction for driver genes. Supplementary Figure S3. Ideogram with chromosome 7 alterations. Supplementary Figure S4. Examples of Exome Copy Number. Supplementary Figure S5. Exploratory Kaplan-Meier plots for clinical covariates. Supplementary Figure …

Supplementary Tables S1 - S10 from The Genetic Basis of Hepatosplenic T-cell Lymphoma

Matthew Stuart McKinney, Andrea B. Moffitt, Philippe Gaulard, Marion Travert et autres

Supplementary Table S1. Sanger validated variants. Supplementary Table S2. Mutations in HSTL driver genes. Supplementary Table S3. Other mutations identified by exome sequencing. Supplementary Table S4. Copy number of HSTL patients and cell lines. Supplementary Table S5. Clinical and pathological characteristics of …

Data from The Genetic Basis of Hepatosplenic T-cell Lymphoma

Matthew McKinney, Andrea B. Moffitt, Philippe Gaulard, Marion Travert et autres

Abstract Hepatosplenic T-cell lymphoma (HSTL) is a rare and lethal lymphoma; the genetic drivers of this disease are unknown. Through whole-exome sequencing of 68 HSTLs, we define recurrently mutated driver genes and copy-number alterations in the disease. Chromatin-modifying genes, including SETD2, INO80, …