Biswajit Das

Orthoflaviviruses use diverse binding modes to engage LDLR family receptors

Chenggong Ji, Laurentia V. Tjang, Biswajit Das, Qiu Yu J. Huang et autres

Orthoflaviviruses are major human pathogens that cause substantial morbidity and mortality worldwide. The viral envelope (E) mediates entry of orthoflaviviruses into host cells by interacting with cellular receptors, including members of the low-density lipoprotein receptor (LDLR) family. Here, we determined cryo-electron microscopy …

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Lachesin is a mosquito receptor for multiple arthritogenic alphaviruses

Jesse Plung, Enzo Mameli, Wanyu Li, Anja C. M. de Bruin et autres

Arthritogenic alphaviruses cause acute febrile illnesses associated with rash and arthritis when they are transmitted to humans through the bite of infected mosquitoes. Among these, chikungunya virus (CHIKV), transmitted primarily through the bite of infected Aedes aegypti and Aedes albopictus mosquitoes, causes …

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Full genome–based evolutionary analyses of FMD virus serotype A including field outbreak strains isolated from India during the period 2008–22

Jajati Keshari Mohapatra, Biswajit Das, Saravanan Subramaniam, Shyam Singh Dahiya et autres

Abstract Comparative complete genome analyses were conducted on 173 field outbreak strains of foot-and-mouth disease virus (FMDV) serotype A, collected from various regions worldwide, including strains that have circulated in India in recent years. Phylogenetic analyses revealed that the majority of isolates …

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Validation of human sensory neurons derived from inducible pluripotent stem cells as a model for latent infection and reactivation by herpes simplex virus 1

Hyung Suk Oh, Shu-Fan Chou, Priya Raja, Jaehoon Shim et autres

Herpes simplex virus 1 (HSV-1) undergoes primary acute lytic replication in mucosal epithelial cells and then spreads to establish latent infection in peripheral neurons including sensory and autonomic neurons. Latent HSV-1 reactivates to cause recurrent cold sores but can also cause more …

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Subclinical infection and localization of foot-and-mouth disease viral RNA/antigens in apparently healthy Asiatic buffalo under natural condition

Rajeev Ranjan, Jitendra K. Biswal, Karam Pal Singh, Biswajit Das et autres

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PP4.10 – 00082 Simultaneous measurement of HIV proviral DNA and cell associated RNA in CSF cells of PWH using single-cell Multiomics

Benjamin Orlinick, Sameet Mehta, Chun‐Yi Lu, Alina P.S. Pang et autres

Commercial human 3D corneal epithelial equivalents for modeling epithelial infection in herpes keratitis

Tatiana Borodianskiy-Shteinberg, Punam Bisht, Biswajit Das, Paul R. Kinchington et autres

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Neuronal miR-9 promotes HSV-1 epigenetic silencing and latency by repressing Oct-1 and Onecut family genes

Yue Deng, Yuqi Lin, Siyu Chen, Yuhang Xiang et autres

Herpes simplex virus 1 (HSV-1) latent infection entails repression of viral lytic genes in neurons. By functional screening using luciferase-expressing HSV-1, we identify ten neuron-specific microRNAs potentially repressing HSV-1 neuronal replication. Transfection of miR-9, the most active candidate from the screen, decreases …

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CCDC 2253390: Experimental Crystal Structure Determination

Biswajit Das, Soumya Sahoo, A. Das, Biswarup Pathak et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2239077: Experimental Crystal Structure Determination

Biswajit Das, Soumya Sahoo, A. Das, Biswarup Pathak et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2239068: Experimental Crystal Structure Determination

Biswajit Das, Sushree Ranjan Sahoo, A. Das, Biswarup Pathak et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2239069: Experimental Crystal Structure Determination

Biswajit Das, Soumya Sahoo, A. Das, Biswarup Pathak et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …