Michael B. Bone

A Vision Transformer Approach for Fully Automated and Scalable Dementia Screening using Clock Drawing Test Images

Michael B. Bone, M. FREEDMAN, Sandra E. Black, Daniel Felsky et autres

BACKGROUND: The clock drawing test (CDT) has been used as a cognitive screening tool for Alzheimer's disease (AD) and other forms of dementia. However, its clinical utility is constrained by requirements for trained scorers and non-standardized diagnostic criteria. METHOD: We developed a …

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A vision transformer approach for fully automated and scalable dementia screening using clock drawing test images

Michael B. Bone, Morris Freedman, Sandra E. Black, Daniel Felsky et autres

INTRODUCTION: The clock drawing test (CDT) screens for dementia but requires trained scorers and lacks standardized criteria. Thus, we developed an automated vision transformer (ViT)-based diagnostic system with convolutional neural network preprocessing for analyzing hand-drawn CDT images. METHODS: = 862; 522 dementia, …

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Individual Differences in Visual versus Semantic Neural Reactivation: Evidence from Severely Deficient Autobiographical Memory

Michael B. Bone, Brian Levine, Bradley R. Buchsbaum

Visual memory is intrinsically linked to the reinstatement of low-level visual features, such as edges and luminosity, within early visual cortex. However, individuals with severely deficient autobiographical memory (SDAM) cannot vividly recollect autobiographical experiences yet display normal everyday functioning. We hypothesized that …

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Individual Differences in Visual vs. Semantic Neural Reactivation: Evidence from Severely Deficient Autobiographical Memory (SDAM)

Michael B. Bone, Brian Levine, Bradley R. Buchsbaum

Visual memory is intricately linked to the reinstatement of low-level visual features, such as edges and luminosity, within the early visual cortex. However, individuals with Severely Deficient Autobiographical Memory (SDAM) cannot vividly recollect autobiographical experiences yet display normal everyday functioning. We hypothesized …

Concurrent feature-specific reactivation within the hippocampus and neocortex facilitates episodic memory retrieval

Michael B. Bone, Bradley R. Buchsbaum

Abstract The hippocampus is a key brain region for the storage and retrieval of episodic memories, but how it performs this function is unresolved. According to the hippocampal indexing theory, the hippocampus stores an event-specific index of the pattern of neocortical activity …

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Detailed Episodic Memory Depends on Concurrent Reactivation of Basic Visual Features within the Posterior Hippocampus and Early Visual Cortex

Michael B. Bone, Bradley R. Buchsbaum

The hippocampus is a key brain region for the storage and retrieval of episodic memories, but how it performs this function is unresolved. Leading theories posit that the hippocampus stores a sparse representation, or "index," of the pattern of neocortical activity that …

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Feature-specific neural reactivation during episodic memory

Michael B. Bone, Fahad N. Ahmad, Bradley R. Buchsbaum

We present a multi-voxel analytical approach, feature-specific informational connectivity (FSIC), that leverages hierarchical representations from a neural network to decode neural reactivation in fMRI data collected while participants performed an episodic visual recall task. We show that neural reactivation associated with low-level …

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Feature-Specific Neural Reactivation during Episodic Memory

Michael B. Bone, Fahad N. Ahmad, Bradley R. Buchsbaum

Abstract When recalling an experience of the past, many of the component features of the original episode may be, to a greater or lesser extent, reconstructed in the mind’s eye. There is strong evidence that the pattern of neural activity that occurred …

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Eye Movement Reinstatement and Neural Reactivation During Mental Imagery

Michael B. Bone, Marie St‐Laurent, Christa Dang, Douglas A. McQuiggan et autres

Half a century ago, Donald Hebb posited that mental imagery is a constructive process that emulates perception. Specifically, Hebb claimed that visual imagery results from the reactivation of neural activity associated with viewing images. He also argued that neural reactivation and imagery …

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Eye-movement reinstatement and neural reactivation during mental imagery

Michael B. Bone, Marie St‐Laurent, Christa Dang, Douglas A. McQuiggan et autres

Abstract Half a century ago, Donald Hebb posited that mental imagery is a constructive process that emulates perception. Specifically, Hebb claimed that visual imagery results from the reactivation of neural activity associated with viewing images. He also argued that neural reactivation and …

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Selective scanpath repetition during memory-guided visual search

Jordana S. Wynn, Michael B. Bone, Michelle C. Dragan, Kari L. Hoffman et autres

Visual search efficiency improves with repetition of a search display, yet the mechanisms behind these processing gains remain unclear. According to Scanpath Theory, memory retrieval is mediated by repetition of the pattern of eye movements or "scanpath" elicited during stimulus encoding. Using …

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A Gaze into the Mind’s Eye: Gaze as an Indicator of Cortical Reinstatement during Mental Imagery

Michael B. Bone

When a previously encountered image is visualized, the spatiotemporal pattern of fixations observed during encoding is often recapitulated. Modern theories posit that fixation recapitulation facilitates, and is facilitated by, the retrieval of detailed internal memory representations. However, there currently exists no direct …