Sex-specific response of the human plasma lipidome to short-term cold exposure
Rattachement africain : de, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Cold-induced lipolysis is widely studied as a potential therapeutic strategy to combat metabolic disease, but its effect on lipid homeostasis in humans remains largely unclear. Blood plasma comprises an enormous repertoire in lipids allowing insights into whole body lipid homeostasis. So far, reported results originate from studies carried out with small numbers of male participants. Here, the blood plasma's lipidome of 78 male and 93 female volunteers, who were exposed to cold below the shivering threshold for 2 h, was quantified by comprehensive lipidomics using high-resolution mass spectrometry. Short-term cold exposure increased the concentrations in 147 of 177 quantified circulating lipids and the response of the plasma's lipidome was sex-specific. In particular, the amounts of generated glycerophospholipid and sphingolipid species differed between the sexes. In women, the BMI could be related with the lipidome's response. A logistic regression model predicted with high sensitivity and specificity whether plasma samples were from male or female subjects based on the cold-induced response of phosphatidylcholine (PC), lysophosphatidylcholine (LPC), and sphingomyelin (SM) species. In summary, cold exposure promotes lipid synthesis by supplying fatty acids generated after lipolysis for all lipid classes. The plasma lipidome, i.e. PC, LPC and SM, shows a sex-specific response, indicating a different regulation of its metabolism in men and women. This supports the need for sex-specific research and avoidance of sex bias in clinical trials.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Sex-specific response of the human plasma lipidome to short-term cold exposure
- Date Crossref
- 01/01/2025
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
University Hospital Regensburg Institute of Clinical Chemistry and Laboratory Medicine pays non établi dans la noticeÉtablissement de santé
-
Leibniz-Institute for Food Systems Biology at the Technical University of Munich ZIEL Institute for Food & Health pays non établi dans la noticeStructure de recherche
-
Fresenius (Germany) pays non établi dans la noticeEntreprise
-
Technical University of Munich pays non établi dans la noticeUniversité ou école supérieure
-
Broad Institute pays non établi dans la noticeOrganisation à but non lucratif
-
BioVariance GmbH pays non établi dans la noticeEntreprise
-
TUM School of Medicine and Health Institute of Nutritional Medicine pays non établi dans la noticeUniversité ou école supérieure
-
The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease pays non établi dans la noticeOrganisation à but non lucratif
Institute of Clinical Chemistry and Laboratory Medicine — University Hospital Regensburg, ZIEL Institute for Food & Health — Leibniz-Institute for Food Systems Biology at the Technical University of Munich et Fresenius (Germany), avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.