Andrea Amorosi

Ulcerative colitis and colorectal cancer: Pathogenic insights and precision strategies for prevention and treatment

Enrico Mini, Stefania Nobili, Ismaela Anna Vascotto, Andrea Amorosi et autres

Ulcerative colitis (UC) is associated with an increased risk of developing colitis-associated colorectal cancer (caCRC), a major complication of long-standing disease. In this review, we examined the pathogenic association between UC and caCRC, highlighting the risk factors, molecular mechanisms, and current strategies …

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CD44 Methylation Levels in Androgen-Deprived Prostate Cancer: A Putative Epigenetic Modulator of Tumor Progression

Virginia Valentini, Raffaella Santi, Valentina Silvestri, Calogero Saieva et autres

Epigenetic changes have been reported to promote the development and progression of prostate cancer (PCa). Compared to normal prostate tissue, tumor samples from patients treated with androgen-deprivation therapy (ADT) show the hypermethylation of genes primarily implicated in PCa progression. A series of …

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Hepatoid thymic carcinoma in a polycythemia vera patient treated with ropeginterferon Alfa-2b: Clinical, histopathological and molecular correlates

Giuseppe Gaetano Loscocco, Margherita Vannucchi, Raffaella Santi, Andrea Amorosi et autres

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Comprehensive genetic analysis of laryngeal leiomyosarcoma by next generation sequencing: a case report

Chiara Mignogna, Eugenia Allegra, Carmelo Laudanna, Cinzia Marinaro et autres

Sarcomas are an uncommon miscellaneous group of mesenchymal tumours with a steady incidence rate of 50 cases per million population. Among the malignant sarcomas, leiomyosarcoma (LMS) is a neoplasm with pure smooth muscle differentiation that is usually divided into three subgroups on …

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Paving the Path for Immune Enhancing Nutrition in Colon Cancer: Modulation of Tumor Microenvironment and Optimization of Outcomes and Costs

Maria Raffaella Ambrosio, Luigi Spagnoli, Bruno Perotti, Federica Petrelli et autres

Introduction. Published evidence suggests that immunonutrition has the potential to decrease postoperative complications and reduce length of stay in patients undergoing surgery for colorectal cancer. However, only a few studies have analyzed the effects of immunonutrition on tumor microenvironment and evaluated its …

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Histopathology and Molecular Genetics in Systemic Mastocytosis: Implications for Clinical Management

Francesca Crupi, Benedetta Sordi, Fiorenza Vanderwert, Francesca Gesullo et autres

The diagnosis of systemic mastocytosis (SM) is based on various clinical, dermatological, serological, and hematological findings but essentially relies on histological evidence of an abnormal increase in tissue-localized mast cells (MCs). The extra-cutaneous organ most frequently affected is the bone marrow (BM), …

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Neoadjuvant Treatment in Muscle-Invasive Bladder Cancer: From the Beginning to the Latest Developments

Giandomenico Roviello, Martina Catalano, Raffaella Santi, Matteo Santoni et autres

Urothelial carcinoma of the bladder is one of the most prevalent cancers worldwide, diagnosed as muscle invasive in 25% of cases. Although several studies have demonstrated an overall 5% absolute survival benefit at 5 years with cisplatin-based combination neoadjuvant treatment, administration of …

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Peripancreatic paraganglioma: Lesson from a round table

Federica Petrelli, Geri Fratini, Andrea Sbrozzi-Vanni, Andrea Giusti et autres

, the identified biases were the emergency setting of the radiologic examination and the very thin mesocolon sheet, which hindered clear definition of the lesion borders. Original endoscopic ultrasonography diagnosis was confirmed, emphasizing the intrinsic limit of this technique in detecting large …

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Surgery for ulcerative colitis complicated with colorectal cancer: when ileal pouch–anal anastomosis is the right choice

Francesco Tonelli, Carmela Di Martino, Andrea Amorosi, Enrico Mini et autres

Patients with ulcerative colitis (UC) are at risk of developing a colorectal cancer. The aim of this study was to examine our experience in the treatment of ulcerative Colitis Cancer (CC), the role of the ileal pouch-anal anastomosis (IPAA), and the clinical …

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Extracellular Matrix in Calcific Aortic Valve Disease: Architecture, Dynamic and Perspectives

Anna Di Vito, Annalidia Donato, Ivan Presta, Teresa Mancuso et autres

Calcific Aortic Valve Disease (CAVD) is the most common valvular heart disease in developed countries and in the ageing population. It is strongly correlated to median age, affecting up to 13% of the population over the age of 65. Pathophysiological analysis indicates …

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Empagliflozin prevents doxorubicin-induced myocardial dysfunction

Jolanda Sabatino, Salvatore De Rosa, Laura Tammè, Claudio Iaconetti et autres

BACKGROUND: Empagliflozin showed efficacy in controlling glycaemia, leading to reductions in HbA1c levels, weight loss and blood pressure, compared to standard treatment. Moreover, the EMPA-REG OUTCOME trial demonstrated a 14% reduction of major adverse cardiovascular events (MACE), a 38% reduction in cardiovascular …

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Calcified Amorphous Tumor of the Heart: Comparison of Ultrasound With Histology

Chiara Mignogna, Andrea Amorosi, Daniele Maselli, Gianluca Santise

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