Claudio Iaconetti

Flow-Responsive Noncoding RNAs in the Vascular System: Basic Mechanisms for the Clinician

Salvatore De Rosa, Claudio Iaconetti, Ceren Eyileten, Masakazu Yasuda et autres

The vascular system is largely exposed to the effect of changing flow conditions. Vascular cells can sense flow and its changes. Flow sensing is of pivotal importance for vascular remodeling. In fact, it influences the development and progression of atherosclerosis, controls its …

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738 Role of non-coding RNA uc.194 and uc.443+A in the intrastent restenosis

Fabiola Boccuto, Laura Tammè, Claudio Iaconetti, Jolanda Sabatino et autres

Abstract Aims Vascular smooth muscle cells (VSMCs) play a key role in the vessel wall, being active partaker in vascular remodelling and influencing multiple pathophysiological phenomena, such as progression of atherosclerosis, in-stent restenosis and vascular reactivity. Recently antisense oligonucleotides have shown promising …

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Reciprocal modulation of Linc-223 and its ligand miR-125a on the basis of platelet function level

Salvatore De Rosa, Sabrina La Bella, Giovanni Canino, Jolanta M. Siller‐Matula et autres

Abstract Background Cardiovacular diseases (CVD) are the leading cause of death worldwide. Platelet play a key role in the pathophysiology of multiple CVD. LincRNAs are long non-coding RNAs transcribed from intergenic DNA segments. Some members of this class were recently associated with …

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Empagliflozin prevents doxorubicin-induced myocardial dysfunction

Jolanda Sabatino, Salvatore De Rosa, Laura Tammè, Claudio Iaconetti et autres

BACKGROUND: Empagliflozin showed efficacy in controlling glycaemia, leading to reductions in HbA1c levels, weight loss and blood pressure, compared to standard treatment. Moreover, the EMPA-REG OUTCOME trial demonstrated a 14% reduction of major adverse cardiovascular events (MACE), a 38% reduction in cardiovascular …

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Erratum. miRNA Regulation of the Hyperproliferative Phenotype of Vascular Smooth Muscle Cells in Diabetes. Diabetes 2018;67:2554–2568

Daniele Torella, Claudio Iaconetti, Roberta Tarallo, Fabiola Marino et autres

In the article cited above, the ND and T2DM graphs in Fig. 3A were inadvertently duplicated, and the ND graph was not shown.The corrected Fig. 3A that includes the ND graph is below.In addition, the first sentence of the legend for Fig. …

Non-coding RNAs in vascular remodeling and restenosis

Ciro Indolfi, Claudio Iaconetti, Clarice Gareri, Alberto Polimeni et autres

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miRNA Regulation of the Hyperproliferative Phenotype of Vascular Smooth Muscle Cells in Diabetes

Daniele Torella, Claudio Iaconetti, Roberta Tarallo, Fabiola Marino et autres

Harnessing the mechanisms underlying the exacerbated vascular remodeling in diabetes mellitus (DM) is pivotal to prevent the high toll of vascular diseases in patients with DM. miRNA regulates vascular smooth muscle cell (VSMC) phenotypic switch. However, miRNA modulation of the detrimental diabetic …

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2150The modulation of miR-129-3p levels in coronary thrombi after primary PCI discloses a novel potential mechanism underlying the no reflow phenomenon

Salvatore De Rosa, Claudio Iaconetti, V Piccione, Maria Teresa Di Martino et autres

Background: Angiographic no-reflow (NR) is described as the absence of reduced coronary flow despite removal of the mechanical obstruction. Platelets have a major impact on the development of NR. In fact, the use of glycoprotein IIb/IIIa receptor antagonists, as well as the …

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P450HDACs drive increased expression of beta-catenin and reduced levels of potassium channels in atrial fibrillation

Clarice Gareri, Antonio Curcio, A Pezone, Sabato Sorrentino et autres

Introduction: Histone deacetylases (HDACs) exert epigenetic modulation of the gene expression, and can be enhanced by circumstantial conditions, including ischemia, that promote disease states in patients (PTS). Atrial fibrillation (AF) is a well-known complication after cardiac surgery (CS). Purpose: To date, it …

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Hindlimb Ischemia Impairs Endothelial Recovery and Increases Neointimal Proliferation in the Carotid Artery

Sabato Sorrentino, Claudio Iaconetti, Salvatore De Rosa, Alberto Polimeni et autres

Peripheral ischemia is associated with higher degree of endothelial dysfunction and a worse prognosis after percutaneous coronary interventions (PCI). However, the role of peripheral ischemia on vascular remodeling in remote districts remains poorly understood. Here we show that the presence of hindlimb …

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Transcoronary Concentration Gradients of Circulating microRNAs in Heart Failure

Salvatore De Rosa, Francesca Eposito, Cristina Carella, Antonio Strangio et autres

AIMS: Circulating levels of microRNAs (miRNAs) are emergent promising biomarkers for cardiovascular disease. Altered expression of miRNAs has been related to heart failure (HF) and cardiac remodelling. We measured the concentration gradients across the coronary circulation to assess their usefulness to diagnose …

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Abstract 19189: Hindlimb Ischemia Impairs Endothelial Recovery and Increase Arterial Neointimal Proliferation in Response to Injury of a Remote District: The Role of Micrornas

Sabato Sorrentino, Claudio Iaconetti, Salvatore De Rosa, Alberto Polimeni et autres

Introduction: Peripheral ischemia is associated with higher degree of endothelial dysfunction in coronary district, as well as to worse prognosis after percutaneous coronary interventions. Hypothesis: to evaluate the effect of peripheral ischemia on arterial remodeling of remote district. Methods: Male Wistar Rats …