Ivan Presta

Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Ivan Presta, Chiara Mignogna, Anna Di Vito, Giuseppe Donato et autres

Beside the typical motor symptoms Parkinson’s disease (PD) is characterized, with varying severity, by autonomic dysfunction. Several studies have shed light on the anatomical and molecular changes that underlie the peripheral neuronal degeneration associated with PD and other Lewy body (LB) diseases …

Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Anna Di Vito, Chiara Mignogna, Natalia Malara, Ivan Presta et autres

Cardiac myxoma is the most common tumor of the heart. The myxoma arises in the region of the interatrial septum and the fossa ovalis, with the left atrium as the most common site of growth. The histogenesis of cardiac myxoma remains unclear. …

Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Anna Di Vito, Manuela Chiarella, Francesco Bennardo, Ivan Presta et autres

Periodontal ligament stem cells (PDLSCs), located in the perivascular space of the periodontium were able to differentiate into periodontal cell types in vitro [1]. In this study, we investigated the effect of three different culture media and of low oxygen tension (1%) …

Ultra-early post-mortem interval (PMI) estimation based on longitudinal plasma protein dynamics in humans: A pilot study

Matteo Antonio Sacco, Natalia MALARA, Ivan Presta, Rocco Turturiello et autres

Accurate estimation of the post-mortem interval (PMI) during the earliest phase after death remains one of the most problematic tasks in forensic pathology. Traditional tanatological methods show limited reliability within the first hours after death due to marked inter-individual variability and strong …

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Distinctive phenogroup to differentiate diagnosis of cardiac myxoma vs cardiovascular disease examining blood-based circulating cell biomarkers

Giuseppe Donato, Chiara Mignogna, Gianluca Santise, Ivan Presta et autres

Abstract Cardiac myxoma (CM) is a potentially life-threatening disease because frequently asymptomatic or debuts with aspecific manifestations. Definitive diagnosis is established by histopathological assessment including tumor and endothelial cell markers. To derive a specific panel of circulating cells antigenically detectable, pre-surgery peripheral …

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Extracellular Matrix in Calcific Aortic Valve Disease: Architecture, Dynamic and Perspectives

Anna Di Vito, Annalidia Donato, Ivan Presta, Teresa Mancuso et autres

Calcific Aortic Valve Disease (CAVD) is the most common valvular heart disease in developed countries and in the ageing population. It is strongly correlated to median age, affecting up to 13% of the population over the age of 65. Pathophysiological analysis indicates …

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Mycosis fungoides and gastric T‑cell lymphoma: A case report

Elisabetta Scali, Ivan Presta, Annalidia Donato, Giusy Schipani et autres

Mycosis fungoides (MF) is a cutaneous malignant lymphoma with an extended clinical course. MF presents in series of dermatological manifestations, beginning with patches and plaques of the skin, and eventually evolving into tumours. Often MF can occur for extended periods without worsening …

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Microenvironment Molecular Profile Combining Glycation Adducts and Cytokines Patterns on Secretome of Short-term Blood-derived Cultures during Tumour Progression

Maria Laura Coluccio, Ivan Presta, Marta Greco, Rita Gervasi et autres

Cancer cells are known to secrete many bioactive factors acting both with paracrine and autocrine mechanisms by which they condition the surrounding microenvironment. At the same time, the intracytoplasmic metabolic activities microenvironment influences the profile of this secretion. It is well known …

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Tailoring Chemometric Models on Blood-Derived Cultures Secretome to Assess Personalized Cancer Risk Score

Maria Laura Coluccio, Francesco Gentile, Ivan Presta, Giuseppe Donato et autres

The molecular protonation profiles obtained by means of an organic electrochemical transistor, which is used for analysis of molecular products released by blood-derived cultures, contain a large amount of information The transistor is based on the conductive polymer PEDOT:PSS comprising super hydrophobic …

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Innate and Adaptive Immunity Linked to Recognition of Antigens Shared by Neural Crest-Derived Tumors

Giuseppe Donato, Ivan Presta, Biagio Arcidiacono, Marco Flavio Michele Vismara et autres

In the adult, many embryologic processes can be co-opted by during cancer progression. The mechanisms of divisions, migration, and the ability to escape immunity recognition linked to specific embryo antigens are also expressed by malignant cells. In particular, cells derived from neural …

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UbcH10 a Major Actor in Cancerogenesis and a Potential Tool for Diagnosis and Therapy

Ivan Presta, Fabiana Novellino, Annalidia Donato, Domenico La Torre et autres

Malignant transformation is a multistep process in which several molecular entities become dysregulated and result in dysfunction in the regulation of cell proliferation. In past years, scientists have gradually dissected the pathways involved in the regulation of the cell cycle. The mitotic …

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Innate Immunity: A Common Denominator between Neurodegenerative and Neuropsychiatric Diseases

Fabiana Novellino, Valeria Saccà, Annalidia Donato, Paolo Zaffino et autres

The intricate relationships between innate immunity and brain diseases raise increased interest across the wide spectrum of neurodegenerative and neuropsychiatric disorders. Barriers, such as the blood-brain barrier, and innate immunity cells such as microglia, astrocytes, macrophages, and mast cells are involved in …

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