Ly Tu

Placental growth factor promotes endothelial activation and inflammatory remodelling in pulmonary hypertension

My Ngoc Ha, Raphaël Thuillet, Mina Ottaviani, Corinne Normand et autres

AIMS: Pulmonary arterial hypertension (PAH) is a progressive cardiopulmonary disorder marked by pulmonary vascular remodelling and vessel loss, paradoxically occurring despite high VEGF signaling. While VEGF/VEGFR pathways are implicated in disease pathogenesis, their role in endothelial and immune cell crosstalk remains poorly …

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Novel role of von Willebrand factor–αvβ3 integrin in human pulmonary artery smooth muscle cell

Sara Abd Al Rahim, Bruno Ribeiro Baptista, Huguette Louis, Cécile V. Denis et autres

Sara Abd Al Rahim, Bruno Ribeiro Baptista, Huguette Louis, Cécile V Denis, Christophe Guignabert, Ly Tu, Véronique Regnault, Patrick Lacolley, Julien Perri

fr (code pays fourni par la source)

Discovery and Preclinical Evaluation of TPM003: A Novel GLP-1/GIP/Glucagon Triple Hormone Receptor Agonist with Robust Efficacy in Obesity and NASH

Nan Zheng, Ly Tu, Pu Xu, Rongfang Chen et autres

Harnessing the simultaneous activation of GLP-1R, GIPR, and GCGR has emerged as a highly promising therapeutic paradigm for obesity and related metabolic diseases, including nonalcoholic steatohepatitis (NASH). Here, we report the discovery of TPM003, a novel unimolecular GLP-1R/GIPR/GCGR triple agonist engineered by …

cn, nl, us (code pays fourni par la source)

Inactivation of the Phosphatase Activity of Soluble Epoxide Hydrolase Modulates SIRT3 and Attenuates Experimental Pulmonary Hypertension

Matthieu Leuillier, Mustapha Kamel Chelgham, Hind Messaoudi, Ly Tu et autres

INTRODUCTION: Pulmonary hypertension (PH) is a severe cardiovascular disorder characterized by elevated pulmonary artery pressure caused by remodeling of the pulmonary circulation. This study aimed to investigate the role of the soluble epoxide hydrolase phosphatase domain (sEH-P) in PH pathogenesis. METHODS: The …

fr, de, us (code pays fourni par la source)

BMP9 Modulates IL-33 Signaling to Mitigate EndMT in Pulmonary Arterial Hypertension

Clarissa Becher, E. Groeneveld, Rozenn Quarck, Beau Neep et autres

BACKGROUND: Pulmonary arterial hypertension (PAH) is a progressive disorder involving disrupted BMP (bone morphogenetic protein) signaling, pulmonary inflammation, and endothelial-to-mesenchymal transition (EndMT). We hypothesized that IL (interleukin)-33 signaling contributes to PAH progression by inducing EndMT and interacting with BMP9, a key modulator …

nl, be, us, de, fr, es (code pays fourni par la source)

Soquelitinib inhibition of IL-2-inducible T cell kinase ameliorates lung damage in murine models of systemic sclerosis

Gonçalo Boleto, Anne Cauvet, Christophe Guignabert, Raphaël Thuillet et autres

BACKGROUND: Interleukin-2-inducible T cell kinase (ITK) is a tyrosine kinase involved in T cell activation, differentiation, and receptor signaling. Soquelitinib (SQL) is a selective, covalent inhibitor of ITK. The abnormal activation of T cells plays a key role in the early inflammatory …

pt, fr, us (code pays fourni par la source)

Glutathione-activated prodrug-based self-delivering nanomedicines for tumoricidal chemo-photodynamic synergistic therapy

Ly Tu, Renjie Huang, Qian Yin, Chao Li et autres

cn (code pays fourni par la source)

S143 StratosPHere 1 study – a novel BMP target engagement biomarker panel for use in clinical trials demonstrates sotatercept alters gene expression in PAH

Ross Jones, Eckart M. D. D. De Bie, Nina Deliu, AYKC Ng et autres

Pulmonary arterial hypertension (PAH) is a rare, life-limiting disease where imbalances in the TGFb superfamily pathways have causal roles in hereditary and idiopathic forms. These pathways are emerging attractive candidates for therapeutic intervention but there is an unmet need for clinically relevant …

gb, fr, us (code pays fourni par la source)

Late Breaking Abstract - StratosPHere 1 study - a novel BMP target engagement biomarker panel for use in clinical trials demonstrates sotatercept alters gene expression in pulmonary arterial hypertension

R. Jones, Eckart M. D. D. De Bie, Nina Deliu, Chi‐Fai Ng et autres

Pulmonary arterial hypertension (PAH) is a rare, life-limiting disease where imbalances in the TGFb superfamily pathways have causal roles in hereditary and idiopathic forms. These pathways are emerging attractive candidates for therapeutic intervention but there is an unmet need for clinically relevant …

gb, fr, us (code pays fourni par la source)

Prognostic Factors for Outcomes in Acute Decompensated Pulmonary Hypertension: Insights from the Prospective ProPULS Study

Laurent Savale, Athénaïs Boucly, Jérémie Pichon, Anne Roche et autres

Managing acute decompensated pulmonary hypertension (PH) is challenging, requiring a multidisciplinary approach. However, prospective data on prognostic factors remain scarce. Aims: The ProPULS study evaluated survival in patients admitted with acute decompensation of pulmonary arterial hypertension (PAH) or chronic thromboembolic PH (CTEPH) …

fr (code pays fourni par la source)

Altered Ventilation in Rats With Established Severe Monocrotaline‐Induced Pulmonary Hypertension: The Role of the Dorsal Hypothalamus

Aliaume Le Pape, Christophe Guignabert, Ly Tu, Nathalie Mougenot et autres

Pulmonary hypertension (PH) is a progressive condition characterized by muscularization of precapillary arteries, chronic inflammation, and a loss of the distal pulmonary circulation. These changes can be mimicked in rats by monocrotaline (MCT) administration. The impact of MCT-induced pulmonary damage on ventilatory …

fr (code pays fourni par la source)

IDO‐1 Promotes Pulmonary Vascular Remodeling Via Kynurenine Pathway in Pulmonary Arterial Hypertension

Zongye Cai, Ly Tu, Siyu Tian, Lin Deng et autres

Background Activation of the plasma kynurenine pathway (KP) may contribute to the progression of pulmonary arterial hypertension (PAH). We investigated the functional role and molecular mechanisms of KP activation in PAH. Methods KP activity was measured in the lungs and plasma of …

nl, cn, fr, se, at, it, de, sk (code pays fourni par la source)