Accès ouvert
2026
article
OpenAlex
Clarissa Becher, Esmee J. Groeneveld, Rozenn Quarck, Beau Neep et autres
BACKGROUND: Pulmonary arterial hypertension (PAH) is a progressive disorder involving disrupted BMP (bone morphogenetic protein) signaling, pulmonary inflammation, and endothelial-to-mesenchymal transition (EndMT). We hypothesized that IL (interleukin)-33 signaling contributes to PAH progression by inducing EndMT and interacting with BMP9, a key modulator …
nl, be, de, fr, us, es
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Wenjun He, Xiaoke Pan, Xiao‐Qing Sun, Beau Neep et autres
Background: Chronic Obstructive Pulmonary Disease (COPD) poses a global vascular challenge in emphysema. As VEGFR2/KDR is a shear stress sensor and pivotal for maintaining vascular integrity, we examined its role in sustaining pulmonary microvascular endothelial barrier integrity. Methods: VEGFR2/KDR expression was assessed …
nl
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Beau Neep, Laura De Heus, Xiaoke Pan, Robert Szulcek et autres
Background: Rare and common genetic variants in SOX17 worsen PAH and accelerate disease progression. Although SOX17 is known as an embryonic transcription factor for arterial differentiation and angiogenesis, its function in the adult vasculature is unclear. We hypothesized that SOX17 drives resilience …
nl, de, gb
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
He Wen, Xiao‐Qing Sun, Beau Neep, H.J. Bogaard et autres
Abstract Background: Chronic Obstructive Pulmonary Disease (COPD) is a growing global health concern with incompletely understood pathophysiology. Loss of pulmonary microvasculature significantly contributes to emphysema development. Given VEGFR2/KDR's role in vascular homeostasis, we hypothesize that VEGFR2 is essential for maintaining lung microvascular …
nl
(code pays fourni par la source)
Accès ouvert
2025
conference-abstract
OpenAlex
Beau Neep, Laura E. de Heus, Xiaoke Pan, Robert Szulcek et autres
Abstract Background: Pulmonary arterial hypertension (PAH) is a fatal lung disease characterized by pulmonary vascular remodeling. Recently, genetic variations in SOX17 were shown to worsen the PAH phenotype and accelerate disease progression. Although SOX17 is a well-known embryonic endothelial-specific transcription factor that …
nl, de
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Keimei Yoshida, Eszter Margit Tóth, Erik Duijvelaar, Beau Neep et autres
Abstract Background The sodium glucose cotransporter 2 (SGLT2) inhibitor may improve mitochondrial biogenesis and attenuate pulmonary vascular remodeling in pulmonary arterial hypertension (PAH). We investigated the impact of empagliflozin in PAH. Methods Lung sections and primary cell cultures isolated from microvascular endothelial …
jp, nl, us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Nadia Bernardi, Beau Neep, Silvano Garibaldi, Eleonora Bianconi et autres
Long non-coding RNA (lncRNA) may be involved in dysfunction of pulmonary artery endothelial cells (PAEC) and, thus, in pulmonary arterial hypertension (PAH) pathobiology. We screened the RNA expression profile of commercial human PAEC (hPAEC) exposed to increased hydrostatic pressure, and found that …
it, nl
(code pays fourni par la source)
2024
conference-abstract
OpenAlex
Keimei Yoshida, Eszter Margit Tóth, Erik Duijvelaar, Beau Neep et autres
Background: Pulmonary arterial hypertension (PAH) is a devastating disease characterized by endothelial proliferation and progressive pulmonary vascular (PV) remodeling. Empagliflozin (EMPA), a sodium glucose cotransporter 2 (SGLT2) inhibitor, benefits heart failure patients, potentially mediated by improved mitochondrial function. This study aimed to …
jp, nl, us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Aukie Hooglugt, Miesje M. van der Stoel, Apeksha Shapeti, Beau Neep et autres
Angiogenesis is a tightly controlled dynamic process demanding a delicate equilibrium between pro-angiogenic signals and factors that promote vascular stability. The spatiotemporal activation of the transcriptional co-factors YAP (herein referring to YAP1) and TAZ (also known WWTR1), collectively denoted YAP/TAZ, is crucial …
nl, be, de
(code pays fourni par la source)
2023
conference-abstract
OpenAlex
Erik Duijvelaar, Keimei Yoshida, Xiao‐Qing Sun, Beau Neep et autres
Introduction: Pulmonary arterial hypertension (PAH) is a devastating disease in which narrowing of the pulmonary vasculature often leads to right ventricular (RV) failure. Empagliflozin (EMPA), a sodium-glucose cotransporter 2 (SGLT2) inhibitor, provides well-established clinical benefits for patients with heart failure. Aims and …
nl, jp
(code pays fourni par la source)