Mohammad S. Mubarak

Preparation, Characterization, and Evaluation of β‐Cyclodextrin Inclusion Hydrogel Films Based on Dates Carboxymethyl Cellulose for Hydrophobic Drug Delivery

Loubna Oumamar, El-Khamsa Soltani, Kailas Krishnat Mali, Ahlem Karbab et autres

This work investigates the carboxymethylcellulose (CMC)-dates (Dt) hydrogel films (HFs) for the controlled delivery of hydrophobic drugs, using citric acid (CA) as a nontoxic cross-linking agent. The model drug Econazole (ECN) was loaded into HFs, and drug release was studied at pH …

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Chemical profiling of Argania spinosa L. Skeels pulp by LC–MS/MS, in vivo evaluation of anti-inflammatory activities, and in silico analysis against COX-2 enzyme: Study on two Algerian ecotypes

Fatima Zohra Khiat, Hanane Sihem Sebaa, Ahlem Karbab, Khadidja Smail et autres

Argania spinosa L. is an endemic North African medicinal plant recognized for its oil, while its fruit pulp remains an underutilized agricultural waste. This study aims to valorize A. spinosa fruit pulp by identifying its polyphenolic profile and evaluating its anti-inflammatory activity. …

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LC–MS/MS phytochemical analysis, in vivo acute toxicity, and anti-inflammatory evaluation of hydromethanolic root extract of Deverra scoparia Coss. & Durieu: Molecular docking and molecular dynamics simulation against the COX-2 enzyme

Ahlem Karbab, Noureddine Charef, Areej M. Jaber, Soraya Ouhida et autres

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Phytochemical investigation of Phyllanthus emblica (Amla) for therapeutic application in urinary tract infection (UTI) management and development of functional tea

Shanza Ashraf, Tariq Ismail, Saeed Akhtar, Muhammad Zulqarnain Khan et autres

Phyllanthus emblica L. (amla) is a medicinal fruit, rich in secondary metabolites with reported anti-inflammatory and antimicrobial effects. The current study aimed to assess the impact of drying and extraction techniques on phytochemical recovery, the biological potential of P. emblica relevant to …

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Plant-based polyphenols as anticancer agents in glioblastoma multiforme: A comprehensive review

Rimsha Sharif, Muhammad Zaeem Ahsan, Sami Ullah, Muqeet Wahid et autres

Glioblastoma Multiform (GBM), an aggressive astrocyte-based tumor of the Central Nervous System (CNS), can often be deadly. Even though multimodal treatment for GBM has gotten better, the rates of survival for 5 years are still poor. GBM is vascularized, diverse, invasive, and …

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RETRACTED: Rauf et al. Neuroinflammatory Markers: Key Indicators in the Pathology of Neurodegenerative Diseases. Molecules 2022, 27, 3194

Abdur Rauf, Himani Badoni, Tareq Abu-Izneid, Ahmed Olatunde et autres

The journal retracts the review article titled "Neuroinflammatory Markers: Key Indicators in the Pathology of Neurodegenerative Diseases" [...].

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Salvadora persica Fruit Methanolic Extract, Nutritional Profiling, Therapeutic Potential in High‐Fat Diet‐Induced Hyperlipidemic Rats: In Vivo, In Vitro, and In Silico Approaches

Nudrat Khursheed, Mostafa A. Abdel‐Maksoud, Salman Alrokayan, Khurram Afzal et autres

ABSTRACT This manuscript presents original research on Salvadora persica fruit, investigating its antioxidant and metabolic properties using in vivo, in vitro, and in silico approaches in high‐fat‐diet induced hyperlipidemic rat models. Nutritional profiling, phytochemical analysis (TPC, DPPH, FRAP, ABTS), and GC–MS analysis …

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Antioxidant Potential of Polyphenolic Compounds, Sources, Extraction, Purification and Characterization Techniques: A Focused Review

Zubair Ahmad, Abdur Rauf, İlkay Erdoğan Orhan, Mohammad S. Mubarak et autres

Polyphenolic compounds, which are abundant phenolic metabolites in plants, have attracted significant attention because of their diverse biological activities and robust antioxidant properties. This review uniquely describes the extraction characterization, and application pipeline for polyphenols, emphasizing their mechanistic antioxidant actions and translational …

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Retraction notice to "Evaluation of fluorinated phospholipid analogs: A study on ADMET profiles, molecular docking and dynamics simulation in anticancer therapy" [Heliyon 11 (2025) e41739]

Saqib Ishaq, Obaid Habib, Abdul Aziz, Raheel Tahir et autres

[This retracts the article DOI: 10.1016/j.heliyon.2025.e41739.].

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Exploring Nephron Repair via Embryonic Stem Cells: A Review of Stem Cell-Based Kidney Therapies

Vica Hilda Amelia, Mohammad S. Mubarak, Riyas Hasan Yazid, Ika Fidianingsih

The nephron, the functional unit of the kidney, is responsible for filtration, reabsorption, and secretion, critical processes for maintaining systemic homeostasis. Damage to nephrons due to pathological conditions such as diabetic nephropathy, glomerulonephritis, and ischemic acute kidney injury can lead to irreversible …

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GC-MS analysis, anti-inflammatory, anti-coagulant, and antioxidant activities of Silybum marianum extracts

Ahlem Karbab, Nuha I. Sweidan, Ashok K. Shakya, Musa Abu Zarqa et autres

Abstract Synthetic medicinal products are expensive and may have serious side effects. In addition, other antimicrobial agents have become increasingly required due to antibiotic resistance. To overcome these problems, people have used medicinal plants for years as a source of medication. Milk …

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Nephro-Pathology Quiz

Mohammad S. Mubarak

Clinical scenario:A 52-year-old man with a 15-year history of poorly controlled hypertension presents to the emergency department with a sudden onset of severe headache, blurring of vision, and shortness of breath.On examination, his blood pressure is 240/135 mmHg, and he appears acutely …

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