Shiping Liu

Whole-transcriptome profiling of the fat body identifies aae-miR-283–ApoLp-Ⅱ/Ⅰ regulation associated with lipid transport and ovarian development in Aedes aegypti

Xiaolin Yang, Houming Ren, Wenzhuo Zhao, Meng Huang et autres

cn (code pays fourni par la source)

A potent EF1A promoter and a minimal U6 promoter enable highly efficient CRISPR genome editing in Aedes aegypti

Xiaolin Yang, Houming Ren, Meng Huang, Wenzhuo Zhao et autres

CRISPR/Cas9 has become a key tool for functional genomics and genetic control strategies in mosquitoes, with its efficiency highly dependent on precise spatiotemporal regulation of Cas9 expression. While germline-specific promoters help reduce resistance and improve drive efficiency, constitutive promoters confer higher editing …

cn (code pays fourni par la source)

EF1A2 is an upstream regulator of the PI3K/akt/TOR pathway linking nutrient metabolism to reproduction in Aedes aegypti

Yuqi Lou, Wenzhuo Zhao, Meng Huang, Xiaolin Yang et autres

cn (code pays fourni par la source)

Competing endogenous RNAs (ceRNAs) orchestrate a gene regulatory network in the Aedes aegypti midgut in response to blood feeding

Yujiao Han, Qingshan Ou, Zhuanzhuan Su, X Wang et autres

Aedes aegypti, a globally widespread mosquito, is a key public health threat due to its ability to transmit multiple deadly arboviruses. The midgut is crucial for the survival, reproduction, and disease transmission of mosquitoes. Competing endogenous RNAs (ceRNAs) regulate gene expression by …

cn (code pays fourni par la source)

Spatiotemporal crosstalk among mitochondrial dynamics, NLRP3 inflammasome activation, and histone lactylation drives α-synuclein pathology in prodromal Parkinson’s disease

Peng Lv, Xia Chen, Shiping Liu, Yu Zhang et autres

This article conducts a systematic search of literature in the fields of neuroscience, cell biology, immunometabolism, etc. from 1990 to 2025, with PubMed/WebofScience as the core database. Experimental and clinical studies covering the core mechanisms of the preprophase of PD (mitochondrial imbalance …

cn (code pays fourni par la source)

Purine nucleoside phosphorylase mediates midgut physiological functions in Aedes aegypti by orchestrating uric acid biosynthesis and oxidative stress homeostasis

Houming Ren, Xiaolin Yang, Xin Wang, Zhuanzhuan Su et autres

Insects excrete nitrogenous waste primarily through the synthesis of uric acid, with purine nucleoside phosphorylase (PNP; AAEL002269) serving as a critical enzyme in this metabolic pathway. Downregulation of PNP has been shown to significantly disrupt blood digestion, ovarian development, and adult longevity …

cn (code pays fourni par la source)

TarP: A microRNA target gene prediction tool utilizing a polymorphic structured alignment approach

Ting Fan, Zhuanzhuan Su, Xin Wang, Lu Zhao et autres

cn (code pays fourni par la source)

Biooxidation of Arsenopyrite by Acidithiobacillus ferriphilus QBS 3 Exhibits Arsenic Resistance Under Extremely Acidic Bioleaching Conditions

Siyu Liu, Xiaoxuan Bai, Shiping Liu, Yuandong Liu

As arsenopyrite is a typical arsenic-bearing sulfide ore, the biooxidation process of arsenopyrite is of great significance for the extraction of gold from arsenic-bearing gold ores and the generation of arsenic-bearing acid mine drainage. During the biooxidation of arsenopyrite, a large amount …

cn (code pays fourni par la source)

Serine Hydroxymethyltransferase Modulates Midgut Physiology in Aedes aegypti Through miRNA Regulation: Insights from Small RNA Sequencing and Gene Expression Analysis

Qian Pu, Yujiao Han, Zhuanzhuan Su, Houming Ren et autres

Aedes aegypti mosquitoes are critical vectors of arboviruses, responsible for transmitting pathogens that pose significant public health challenges. Serine hydroxymethyltransferase (SHMT), a key enzyme in one-carbon metabolism, plays a vital role in various biological processes, including DNA synthesis, energy metabolism, and cell …

cn (code pays fourni par la source)

Regulatory mechanisms of nitrogen homeostasis in insect growth and development

Houming Ren, Qian Pu, Xiaolin Yang, Symphony Kashyap et autres

Nitrogen is an essential element for the synthesis of proteins, nucleic acids, and various other critical biological molecules in insects. The maintenance of nitrogen homeostasis in insects is achieved through a balance of dietary intake, metabolic conversion, and excretion. Insects primarily acquire …

cn (code pays fourni par la source)

SHMT, SHMTML and PRPS1 synergize to regulate blood digestion and nutrient metabolism in Aedes aegypti mosquitoes

Qian Pu, Houming Ren, Qingshan Ou, Xiaolin Yang et autres

Mosquitoes rely on vertebrate blood for nutrients vital for ovarian development. The enzyme serine hydroxymethyltransferase (SHMT) is crucial for amino acid and one‑carbon metabolism, playing a significant role in blood digestion and nutrient use in mosquitoes, though its functional mechanism remains further …

cn (code pays fourni par la source)

Spatial confinement effect of zeolite Silicalite-1 on dispersing high loading Cu nanoparticles and their superior ethanol dehydrogenation catalytic performance

Yanfei Zhang, Haocheng Hu, Zeyu Yang, Shiping Liu et autres

cn (code pays fourni par la source)