Regulatory mechanisms of nitrogen homeostasis in insect growth and development

Le résumé fourni par la source

Nitrogen is an essential element for the synthesis of proteins, nucleic acids, and various other critical biological molecules in insects. The maintenance of nitrogen homeostasis in insects is achieved through a balance of dietary intake, metabolic conversion, and excretion. Insects primarily acquire nitrogen from their diet, which is subsequently metabolized into amino acids, proteins, and other vital biomolecules following digestion and absorption. Excess nitrogen is excreted in forms such as uric acid, allantoin, allantoic acid, urea, and ammonia. Disruptions in nitrogen regulation can result in ammonia toxicity and abnormal production or excretion of nitrogenous metabolites, including uric acid, ultimately impairing insect development and survival. This review examines the mechanisms underlying nitrogen homeostasis in insects, with a focus on the intricate regulatory roles of carbohydrate metabolism, amino acid metabolism, uric acid metabolism, urea and polyamine metabolism, ammonia transport pathways, and symbiotic interactions. By elucidating these processes, this review aims to enhance our understanding of insect nutritional metabolism and developmental biology, while offering novel perspectives for the development of more effective pest management strategies.

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