Jeffrey M. Verboon

Spatiotemporal Dynamics of Protein Recruitment During Cell Wound Repair

Mitsutoshi Nakamura, Justin Hui, Jeffrey M. Verboon, Susan M. Parkhurst

Abstract Injuries to individual cells happen frequently as a result of physiological and environmental stresses during their normal daily functions that can lead to a ruptured cell cortex (plasma membrane and underlying cortical cytoskeleton). The capacity of cells to rapidly repair general …

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Abstract 2126: LY6G6D targeting with a T cell engager is a promising therapeutic for MSS colorectal cancer

Burcu Yigit, Prasuna Paluru, Eglė Jurgaitytė, Kevin A. Nuno et autres

T cell engagers (TCEs) are proving to be a potent therapeutic strategy for the treatment of solid tumors. Clinical data have shown that TCEs can drive T cell activity in "cold" tumors, including colorectal cancer. However, identifying highly specific tumor antigen targets …

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Identifying optimal tumor-associated antigen combinations with single-cell genomics to enable multi-targeting therapies

Matthew A. Nix, Caleb A. Lareau, Jeffrey M. Verboon, David Kugler

Targeted antibody-based therapy for oncology represents a highly efficacious approach that has demonstrated robust responses against single tumor-associated antigen (TAA) targets. However, tumor heterogeneity presents a major obstacle for targeting most solid tumors due to a lack of single targets that possess …

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1343 A CB21-targeted T cell engager is a promising therapeutic for the treatment of colorectal cancer

Burcu Yigit, Prasuna Paluru, Eglė Jurgaitytė, Kevin A. Nuno et autres

Background Colorectal cancer (CRC) remains of high unmet medical need. T cell engagers as a modality have gained attraction in solid tumors, but despite the early data that T cells can infiltrate cold CRC tumors with therapies such as Cibisatamab, treatment remains …

Genome Sequencing for Diagnosing Rare Diseases

Monica H. Wojcik, Gabrielle Lemire, Eva Berger, Maha S. Zaki et autres

BACKGROUND: Genetic variants that cause rare disorders may remain elusive even after expansive testing, such as exome sequencing. The diagnostic yield of genome sequencing, particularly after a negative evaluation, remains poorly defined. METHODS: We sequenced and analyzed the genomes of families with …

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Latent human herpesvirus 6 is reactivated in CAR T cells

Caleb A. Lareau, Yajie Yin, Katie Maurer, Katalin Sándor et autres

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Author Correction: Massively parallel single-cell mitochondrial DNA genotyping and chromatin profiling

Caleb A. Lareau, Leif S. Ludwig, Christoph Muus, Satyen H. Gohil et autres

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A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology

Parsa Akbari, Dragana Vuckovic, Luca Stefanucci, Tao Jiang et autres

Blood cells contain functionally important intracellular structures, such as granules, critical to immunity and thrombosis. Quantitative variation in these structures has not been subjected previously to large-scale genetic analysis. We perform genome-wide association studies of 63 flow-cytometry derived cellular phenotypes-including cell-type specific …

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Unique Capabilities of Genome Sequencing for Rare Disease Diagnosis

Monica H. Wojcik, Gabrielle Lemire, Maha S. Zaki, Mariel Wissman et autres

Background: Causal variants underlying rare disorders may remain elusive even after expansive gene panels or exome sequencing (ES). Clinicians and researchers may then turn to genome sequencing (GS), though the added value of this technique and its optimal use remain poorly defined. …

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Single-cell multi-omics of mitochondrial DNA disorders reveals dynamics of purifying selection across human immune cells

Caleb A. Lareau, Sonia M. Dubois, Frank A. Buquicchio, Yu-Hsin Hsieh et autres

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Centralspindlin proteins Pavarotti and Tumbleweed along with WASH regulate nuclear envelope budding

Kerri Davidson, Mitsutoshi Nakamura, Jeffrey M. Verboon, Susan M. Parkhurst

Nuclear envelope (NE) budding is a nuclear pore-independent nuclear export pathway, analogous to the egress of herpesviruses, and required for protein quality control, synapse development, and mitochondrial integrity. The physical formation of NE buds is dependent on the Wiskott-Aldrich Syndrome protein, Wash, …

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Single-cell multi-omics reveals dynamics of purifying selection of pathogenic mitochondrial DNA across human immune cells

Caleb A. Lareau, Sonia M. Dubois, Frank A. Buquicchio, Yu-Hsin Hsieh et autres

Abstract Cells experience intrinsic and extrinsic pressures that affect their proclivity to expand and persist in vivo . In congenital disorders caused by loss-of-function mutations in mitochondrial DNA (mtDNA), metabolic vulnerabilities may result in cell-type specific phenotypes and depletion of pathogenic alleles, …

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