Mitsutoshi Nakamura

Spatiotemporal Dynamics of Protein Recruitment During Cell Wound Repair

Mitsutoshi Nakamura, Justin Hui, Jeffrey M. Verboon, Susan M. Parkhurst

Abstract Injuries to individual cells happen frequently as a result of physiological and environmental stresses during their normal daily functions that can lead to a ruptured cell cortex (plasma membrane and underlying cortical cytoskeleton). The capacity of cells to rapidly repair general …

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Reversible Actin modifications by Mical and SelR regulate dynamic actomyosin ring functions during cell wound repair

Mitsutoshi Nakamura, Justin Hui, Susan M. Parkhurst

Cell wound repair requires rapid and coordinated remodeling of the actin cytoskeleton to restore cortex integrity. Here, we show that a Rab35-Mical-SelR pathway regulates actomyosin ring dynamics through reversible actin redox. We find that Rab35 is recruited to wounds and is essential …

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Septin complexes: Ahead of the curve

Mitsutoshi Nakamura, Susan M. Parkhurst

Individual cells have robust repair systems to survive cell cortex damage caused by mechanical and chemical stresses, allowing them to maintain the integrity of tissues and organs. The contraction of an actomyosin ring at the wound edge is a major mechanism for …

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Calcium influx rapidly establishes distinct spatial recruitments of Annexins to cell wounds

Mitsutoshi Nakamura, Susan M. Parkhurst

To survive daily damage, the formation of actomyosin ring at the wound edge is required to rapidly close cell wounds. Calcium influx is one of the start signals for these cell wound repair events. Here, we find that the rapid recruitment of …

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Two Septin complexes mediate actin dynamics during cell wound repair

Viktor Stjepić, Mitsutoshi Nakamura, Justin Hui, Susan M. Parkhurst

Cells have robust wound repair systems to prevent further damage or infection and to quickly restore cell cortex integrity when exposed to mechanical and chemical stress. Actomyosin ring formation and contraction at the wound edge are major events during closure of the …

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Calcium influx rapidly establishes distinct spatial recruitments of Annexins to cell wounds

Mitsutoshi Nakamura, Susan M. Parkhurst

Abstract To survive daily damage, the formation of actomyosin ring at the wound periphery is required to rapidly close cell wounds. Calcium influx is one of the start signals for these cell wound repair events. Here, we find that rapid recruitment of …

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Nuclear envelope budding: Getting large macromolecular complexes out of the nucleus

Kevin Sule, Mitsutoshi Nakamura, Susan M. Parkhurst

Transport of macromolecules from the nucleus to the cytoplasm is essential for nearly all cellular and developmental events, and when mis-regulated, is associated with diseases, tumor formation/growth, and cancer progression. Nuclear Envelope (NE)-budding is a newly appreciated nuclear export pathway for large …

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Two Septin Complexes Mediate Actin Dynamics During Cell Wound Repair

Viktor Stjepić, Mitsutoshi Nakamura, Justin Hui, Susan M. Parkhurst

ABSTRACT Cells have robust wound repair systems to prevent further damage or infection and to quickly restore cell cortex integrity when exposed to mechanical and chemical stress. Actomyosin ring formation and contraction at the wound edge are major events during closure of …

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Faculty Opinions recommendation of Protrusion growth driven by myosin-generated force.

Susan M. Parkhurst, Mitsutoshi Nakamura

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Wound repair: Two distinct Rap1 pathways close the gap

Mitsutoshi Nakamura, Susan M. Parkhurst

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Correction: Hui et al. Wrangling Actin Assemblies: Actin Ring Dynamics during Cell Wound Repair. Cells 2022, 11, 2777

Justin Hui, Viktor Stjepić, Mitsutoshi Nakamura, Susan M. Parkhurst

In the original publication [...].

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Centralspindlin proteins Pavarotti and Tumbleweed along with WASH regulate nuclear envelope budding

Kerri Davidson, Mitsutoshi Nakamura, Jeffrey M. Verboon, Susan M. Parkhurst

Nuclear envelope (NE) budding is a nuclear pore-independent nuclear export pathway, analogous to the egress of herpesviruses, and required for protein quality control, synapse development, and mitochondrial integrity. The physical formation of NE buds is dependent on the Wiskott-Aldrich Syndrome protein, Wash, …

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