Claudia Kitzmüller

The role of IgG1 and IgG4 as dominant IgE-blocking antibodies shifts during allergen immunotherapy

Maria Regina Strobl, Hilal Demir, Gabriela Sánchez Acosta, Anja Drescher et autres

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T-Cell Subset Changes During the First Year of Pre-Seasonal Allergoid Allergen-Specific Immunotherapy

Manuel Reithofer, Simone Böll, Claudia Kitzmüller, F. Horák et autres

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Human neutrophils require short exposure to cytokines and allergen to become functional antigen‐presenting cells

Dominika Polak, Adelheid Elbe‐Bürger, Claudia Kitzmüller, Gerhard J. Zlabinger et autres

Human neutrophils require short exposure to cytokines and allergen to become functional antigen-presenting cellsTo the Editor, High numbers of neutrophils accumulate in late-phase reactions (LPRs) of IgE-mediated allergy.We previously reported that neutrophils exposed to GM-CSF (granulocyte macrophage colonystimulating factor), IL-3 (interleukin 3), …

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The secretome of irradiated peripheral blood mononuclear cells attenuates activation of mast cells and basophils

Maria Laggner, Gabriela Sánchez Acosta, Claudia Kitzmüller, Dragan Copic et autres

BACKGROUND: IgE-mediated hypersensitivity is becoming increasingly prevalent and activation of mast cells and basophils represent key events in the pathophysiology of allergy. We have previously reported that the secretome of γ-irradiated peripheral blood mononuclear cells (PBMCsec) exerts beneficial anti-inflammatory effects. Yet, its …

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Adjuvants and Vaccines Used in Allergen-Specific Immunotherapy Induce Neutrophil Extracellular Traps

Jasmine Karacs, Manuel Reithofer, Claudia Kitzmüller, Markus Kraller et autres

Aluminum hydroxide (alum) and monophosphoryl-lipid A (MPLA) are conventional adjuvants in vaccines for allergen-specific immunotherapy (AIT). Alum triggers the release of neutrophil extracellular traps (NETs) by neutrophils. NETs contain expelled decondensed chromatin associated with granular material and may act as danger-associated molecular …

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IgE‐cross‐blocking antibodies to Fagales following sublingual immunotherapy with recombinant Bet v 1

João Rodrigues Grilo, Claudia Kitzmüller, Lorenz Aglas, Gabriela Sánchez Acosta et autres

BACKGROUND: Evidence has accumulated that birch pollen immunotherapy reduces rhinoconjunctivitis to pollen of birch homologous trees. Therapeutic efficacy has been associated with IgE-blocking IgG antibodies. We have recently shown that sera collected after 16 weeks of sublingual immunotherapy with recombinant Bet v …

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Alum triggers infiltration of human neutrophils ex vivo and causes lysosomal destabilization and mitochondrial membrane potential‐dependent NET‐formation

Manuel Reithofer, Jasmine Karacs, Johanna Strobl, Claudia Kitzmüller et autres

Abstract Aluminium salts have been used in vaccines for decades. However, the mechanisms underlying their adjuvant effect are still unclear. Neutrophils, the first immune cells at the injection site, can release cellular DNA together with granular material, so‐called neutrophil extracellular traps (NETs). …

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IgE-blocking antibodies following SLIT with recombinant Mal d 1 accord with improved apple allergy

Gabriela Sánchez Acosta, Tamar Kinaciyan, Claudia Kitzmüller, Christian Möbs et autres

BACKGROUND: We recently reported that 16 weeks of sublingual immunotherapy (SLIT) with recombinant (r) Mal d 1, but not rBet v 1, significantly improved birch pollen-related apple allergy. Allergen-specific IgE-blocking IgG antibodies have been associated with clinical efficacy. OBJECTIVE: We compared the …

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NSG mice humanized with allergen‐specific T‐cell lines as in vivo model of respiratory allergy

Caterina Vizzardelli, Felix Zimmann, Birgit Nagl, Claudia Kitzmüller et autres

experiment, human patients are genetically diverse and develop allergies to a wide range of allergens.The present (Figures 12) and previous 7 study of hypersensitivity in mice employed the DNFB model in C57BL/6 mice and found no evidence for involvement of IL-36 or …

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Development of a novel Ara h 2 hypoallergen with no IgE binding or anaphylactogenic activity

Angelika Tscheppe, Dieter Palmberger, Leonie S. van Rijt, Tanja Kalic et autres

BACKGROUND: To date, no safe allergen-specific immunotherapy for patients with peanut allergy is available. Previous trials were associated with severe side effects. OBJECTIVE: We sought to determine the relative importance of conformational and linear IgE-binding epitopes of the major peanut allergen Ara …

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Nitrated food proteins induce a regulatory immune response associated with allergy prevention after oral exposure in a Balb/c mouse food allergy model

Nazanin Samadi, Martina Klems, Denise Heiden, Renate Bauer et autres

BACKGROUND: Food allergy is associated with a high personal health and economic burden. For immunomodulation toward tolerance, food compounds could be chemically modified, for example, by posttranslational protein nitration, which also occurs via diet-derived nitrating agents in the gastrointestinal tract. OBJECTIVE: We …

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T‐cell‐derived cytokines enhance the antigen‐presenting capacity of human neutrophils

Nazanin Samadi, Dominika Polak, Claudia Kitzmüller, Peter Steinberger et autres

Activated allergen-specific Th2 and Th1 cells release cytokines that transform neutrophils into functional APCs characterized by the expression of HLA-DR and CD58 as well as enhanced survival and antigen uptake, irrespectively of the presence of IL-10, which reduces allergen uptake by neutrophils.

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