Angelika Tscheppe

The Major Peanut Allergen Ara h 2 Produced in Nicotiana benthamiana Contains Hydroxyprolines and Is a Viable Alternative to the E. Coli Product in Allergy Diagnosis

Öykü Üzülmez, Tanja Kalic, Vanessa Mayr, Nina Lengger et autres

Peanut allergy is a potentially life-threatening disease that is mediated by allergen-specific immunoglobulin E (IgE) antibodies. The major peanut allergen Ara h 2, a 2S albumin seed storage protein, is one of the most dangerous and potent plant allergens. Ara h 2 …

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Development of a novel Ara h 2 hypoallergen with no IgE binding or anaphylactogenic activity

Angelika Tscheppe, Dieter Palmberger, Leonie S. van Rijt, Tanja Kalic et autres

BACKGROUND: To date, no safe allergen-specific immunotherapy for patients with peanut allergy is available. Previous trials were associated with severe side effects. OBJECTIVE: We sought to determine the relative importance of conformational and linear IgE-binding epitopes of the major peanut allergen Ara …

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Fish-derived low molecular weight components modify bronchial epithelial barrier properties and release of pro-inflammatory cytokines

Tanja Kalic, Isabella Ellinger, Sandip D. Kamath, Chiara Palladino et autres

The prevalence of fish allergy among fish-processing workers is higher than in the general population, possibly due to sensitization via inhalation and higher exposure. However, the response of the bronchial epithelium to fish allergens has never been explored. Parvalbumins (PVs) from bony …

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Contribution of conformational and linear IgE epitopes to ara H 2-specific IgE-binding - in vitro and in vivo studies

Angelika Tscheppe

Contribution of conformational and linear IgE epitopes to ara H 2-specific IgE-binding - in vitro and in vivo studies

Angelika Tscheppe

Lactobacillus buchneri S-layer as carrier for an Ara h 2-derived peptide for peanut allergen-specific immunotherapy

Julia Anzengruber, Merima Bublin, Eva Bönisch, Bettina Janesch et autres

Peanut allergy is an IgE-mediated severe hypersensitivity disorder. The lack of a treatment of this potentially fatal allergy has led to intensive research on vaccine development. Here, we describe the design and initial characterization of a carrier-bound peptide derived from the most …

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Influence of Conformational and Linear IgE Epitopes on Ara h 2-Specific IgE-Binding

Angelika Tscheppe, Dieter Palmberger, Christian Radauer, Merima Bublin et autres

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Recombinant Allergens in Structural Biology, Diagnosis, and Immunotherapy

Angelika Tscheppe, Heimo Breiteneder

The years 1988-1995 witnessed the beginning of allergen cloning and the generation of recombinant allergens, which opened up new avenues for the diagnosis and research of human allergic diseases. Most crystal and solution structures of allergens have been obtained using recombinant allergens. …

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Contents Vol. 172, 2017

Heimo Breiteneder, Angelika Tscheppe, D. Charpin, M. Ramadour et autres

rs20541 Polymorphism in Finnish Adult Asthma Patients

6th International Symposium on Molecular Allergology (ISMA)

Christiane Hilger, Kyra Swiontek, Jörg Fischer, François Hentges et autres

Background: Delayed food anaphylaxis upon consumption of red meat is attributed to specific IgE-antibodies directed to galactose-α-1,3-galactose (α-Gal).Anaphylactic reactions may occur after ingestion of meat from different mammals, mainly beef and pork, but reactions to lamb, rabbit or horse have also been …

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