Jasmine Karacs

SLCO4A1 expression is associated with activated inflammatory pathways in high-grade serous ovarian cancer

Stephanie Koller, Jonatan Kendler, Jasmine Karacs, Andrea M. Wolf et autres

Patients with high-grade serous ovarian cancer (HGSOC) have a very poor overall survival. Current therapeutic approaches do not bring benefit to all patients. Although genetic alterations and molecular mechanisms are well characterized, the molecular pathological conditions are poorly investigated. Solute carrier organic …

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Adjuvants and Vaccines Used in Allergen-Specific Immunotherapy Induce Neutrophil Extracellular Traps

Jasmine Karacs, Manuel Reithofer, Claudia Kitzmüller, Markus Kraller et autres

Aluminum hydroxide (alum) and monophosphoryl-lipid A (MPLA) are conventional adjuvants in vaccines for allergen-specific immunotherapy (AIT). Alum triggers the release of neutrophil extracellular traps (NETs) by neutrophils. NETs contain expelled decondensed chromatin associated with granular material and may act as danger-associated molecular …

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Tumor Growth Rate Estimates Are Independently Predictive of Therapy Response and Survival in Recurrent High-Grade Serous Ovarian Cancer Patients

Thomas Bartl, Jasmine Karacs, Caroline Kreuzinger, Stephanie Pfaffinger et autres

This study aimed to assess the predictive value of tumor growth rate estimates based on serial cancer antigen-125 (CA-125) levels on therapy response and survival of patients with recurrent high-grade serous ovarian cancer (HGSOC). In total, 301 consecutive patients with advanced HGSOC …

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Alum triggers infiltration of human neutrophils ex vivo and causes lysosomal destabilization and mitochondrial membrane potential‐dependent NET‐formation

Manuel Reithofer, Jasmine Karacs, Johanna Strobl, Claudia Kitzmüller et autres

Abstract Aluminium salts have been used in vaccines for decades. However, the mechanisms underlying their adjuvant effect are still unclear. Neutrophils, the first immune cells at the injection site, can release cellular DNA together with granular material, so‐called neutrophil extracellular traps (NETs). …

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Patient-derived cell line models revealed therapeutic targets and molecular mechanisms underlying disease progression of high grade serous ovarian cancer

Caroline Kreuzinger, Isabel von der Decken, Andrea M. Wolf, Magdalena Gamperl et autres

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Geobacter-dominated biofilms used as amperometric BOD sensors

Audrey S. Commault, Gavin Lear, Solène Bouvier, Lukas Feiler et autres

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