Ruth Tarpey

An Integrated Oxygen‐Supplying Device and Predictive Multiphysics Model for Extended Ambient Transport of Insulin‐Producing Cells

Daniel A. Domingo‐Lopez, Ruth Tarpey, Benjamin Brennan, Bryan D. Boyle et autres

ABSTRACT Cell therapies are a transformative pillar in healthcare, offering treatments for a diverse range of rare and chronic diseases. However, their complex supply chain relies on cryopreservation and cold‐chain logistics, which limits access to these life‐saving treatments, and the freeze–thaw process …

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From cold chain to ambient: Benefits, risks, and evidence across cell therapy logistics

John Gostage, Daniel A. Domingo‐Lopez, Ruth Tarpey, Garry P. Duffy et autres

With the exponential growth in the number of cell-based therapies, there is a need to look more closely at a critical factor that unites all these therapies, i.e., cryopreservation, which is currently deemed the gold standard for the storage and shipment of …

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Investigation of swelling mechanisms in self-adherent microneedles

Ruth Tarpey, Shahrin Islam, Bruno Bernardo, Manisha Singh et autres

Abstract Swellable microneedles (MNs) expand to mechanically interlock with wet biological tissue, offering improved adhesion and enhanced drug delivery over non-swellable counterparts. This study numerically evaluates how the material and geometric parameters of swellable MN arrays influence shape change. Using finite element …

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Development of A 3D Lung Tumor Model For Cell Death Assessment in Microwave Ablation

Laura B. Gallagher, Tapas Mitra, Victoria Ward, Ruth Tarpey et autres

Abstract Primary lung cancer is the leading cause of cancer‐related death worldwide. Recent statistics estimate 1.8 million new cases and 1.6 million deaths per year. Despite significant advances in surgery, chemotherapy, and radiotherapy, the 5‐year survival rate remains at just 18%. Thermal …

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Exploring therapy transport from implantable medical devices using experimentally informed computational methods

Lesley Trask, Niamh A. Ward, Ruth Tarpey, Rachel Beatty et autres

Implantable medical devices that can facilitate therapy transport to localized sites are being developed for a number of diverse applications, including the treatment of diseases such as diabetes and cancer, and tissue regeneration after myocardial infraction. These implants can take the form …

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Intermittent actuation attenuates fibrotic behaviour of myofibroblasts

Niamh A. Ward, Shirley A. Hanley, Ruth Tarpey, Lucien H. J. Schreiber et autres

The foreign body response (FBR) to implanted materials culminates in the deposition of a hypo-permeable, collagen rich fibrotic capsule by myofibroblast cells at the implant site. The fibrotic capsule can be deleterious to the function of some medical implants as it can …

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Soft robot–mediated autonomous adaptation to fibrotic capsule formation for improved drug delivery

Rachel Beatty, Keegan L. Mendez, Lucien H. J. Schreiber, Ruth Tarpey et autres

The foreign body response impedes the function and longevity of implantable drug delivery devices. As a dense fibrotic capsule forms, integration of the device with the host tissue becomes compromised, ultimately resulting in device seclusion and treatment failure. We present FibroSensing Dynamic …

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The influence of substrate stiffness on interfacial stresses for adhesive microfibrils

Ruth Tarpey, William Ronan

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