Development of A 3D Lung Tumor Model For Cell Death Assessment in Microwave Ablation
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Le résumé fourni par la source
Abstract Primary lung cancer is the leading cause of cancer‐related death worldwide. Recent statistics estimate 1.8 million new cases and 1.6 million deaths per year. Despite significant advances in surgery, chemotherapy, and radiotherapy, the 5‐year survival rate remains at just 18%. Thermal ablation is an established treatment that is safe and effective. It refers to the local application of controlled heat to induce irreversible cell injury and ultimately tumor apoptosis and necrosis. This approach is particularly suitable for the treatment of small tumors in patients who are not suitable for surgery. However, the lack of suitable benchtop models to assess ablation devices complicates prognostic prediction and the development of effective treatment strategies. In this context, the development of a 3D lung tumor model is presented using a cancer cell‐laden hydrogel composed of 2% hyaluronic acid–tyramine (HA‐TA) and 0.5% agarose, resulting in a tumor mimetic of clinically relevant size. This innovative model provides a valuable platform for testing ablation devices and provides insights that can significantly improve prognostic ability and refine treatment approaches for lung cancer patients.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Development of A 3D Lung Tumor Model For Cell Death Assessment in Microwave Ablation
- Date Crossref
- 09/08/2024
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Ollscoil na Gaillimhe – University of Galway Lambe Institute for Translational Research pays non établi dans la noticeUniversité ou école supérieure
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Anatomy and Regenerative Medicine Institute College of Medicine Nursing and Health Sciences University of Galway Galway H91 W2TY Ireland Anatomy and Regenerative Medicine Institute pays non établi dans la noticeUniversité ou école supérieure
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Discipline of Surgery Lambe Institute for Translational Research University of Galway Galway H91 YR71 Ireland pays non établi dans la noticeUniversité ou école supérieure
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R& pays non établi dans la noticeInstitution
Lambe Institute for Translational Research — Ollscoil na Gaillimhe – University of Galway, Anatomy and Regenerative Medicine Institute — Anatomy and Regenerative Medicine Institute College of Medicine Nursing and Health Sciences University of Galway Galway H91 W2TY Ireland et Discipline of Surgery Lambe Institute for Translational Research University of Galway Galway H91 YR71 Ireland, avec 1 autre affiliation.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.