Exploring therapy transport from implantable medical devices using experimentally informed computational methods
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Le résumé fourni par la source
Implantable medical devices that can facilitate therapy transport to localized sites are being developed for a number of diverse applications, including the treatment of diseases such as diabetes and cancer, and tissue regeneration after myocardial infraction. These implants can take the form of an encapsulation device which encases therapy in the form of drugs, proteins, cells, and bioactive agents, in semi-permeable membranes. Such implants have shown some success but the nature of these devices pose a barrier to the diffusion of vital factors, which is further exacerbated upon implantation due to the foreign body response (FBR). The FBR results in the formation of a dense hypo-permeable fibrous capsule around devices and is a leading cause of failure in many implantable technologies. One potential method for overcoming this diffusion barrier and enhancing therapy transport from the device is to incorporate local fluid flow. In this work, we used experimentally informed inputs to characterize the change in the fibrous capsule over time and quantified how this impacts therapy release from a device using computational methods. Insulin was used as a representative therapy as encapsulation devices for Type 1 diabetes are among the most-well characterised. We then explored how local fluid flow may be used to counteract these diffusion barriers, as well as how a more practical pulsatile flow regimen could be implemented to achieve similar results to continuous fluid flow. The generated model is a versatile tool toward informing future device design through its ability to capture the expected decrease in insulin release over time resulting from the FBR and investigate potential methods to overcome these effects.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Exploring therapy transport from implantable medical devices using experimentally informed computational methods
- Date Crossref
- 01/01/2024
- Éditeur
- Royal Society of Chemistry (RSC)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Ollscoil na Gaillimhe – University of Galway Centre for Research in Medical Devices pays non établi dans la noticeUniversité ou école supérieure
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Trinity College Dublin SFI Centre for Advanced Materials and BioEngineering Research Centre (AMBER) pays non établi dans la noticeUniversité ou école supérieure
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Advanced Materials and BioEngineering Research pays non établi dans la noticeStructure de recherche
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School of Engineering Biomechanics Research Centre (BMEC) pays non établi dans la noticeUniversité ou école supérieure
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School of Medicine Anatomy and Regenerative Medicine Institute (REMEDI) pays non établi dans la noticeUniversité ou école supérieure
Centre for Research in Medical Devices — Ollscoil na Gaillimhe – University of Galway, SFI Centre for Advanced Materials and BioEngineering Research Centre (AMBER) — Trinity College Dublin et Advanced Materials and BioEngineering Research, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.