Thomas H. Shaffer

Natural History of Morquio A Syndrome

Shunji Tomatsu, Kimberly Klipner, Marie Sahou, Jacky M. Guerrero-Vargas et autres

Mucopolysaccharidosis IVA (Morquio A) is a progressive lysosomal disorder caused by a deficiency of N-acetylgalactosamine-6-sulfate sulfatase, resulting in the accumulation of glycosaminoglycans, primarily in cartilage and bone. The condition leads to skeletal dysplasia, impaired ossification, and growth imbalance, causing cervical compression, tracheal …

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Speed of intravenous fluid on glycocalyx integrity and central blood volume in a porcine septic shock model

Yosef Levenbrown, Md Jobayer Hossain, Paul T. Fawcett, Marjorie Postell et autres

BACKGROUND: It is unclear whether the rate of intravenous fluid (IVF) administration in sepsis influences glycocalyx breakdown. This study aimed to measure the effect of rapid versus slow fluid bolus in a septic pig model on the integrity of the glycocalyx by …

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Relationships between pulmonary function testing and polysomnography in adolescents with severe obesity

Abigail Strang, Benjamin Crain, Linhda Nguyen, Md Jobayer Hossain et autres

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A bioabsorbable adhesive wrap for sutureless arterial repair: Initial development and preclinical testing in a rat model

Prasad Nithianandam, Anne Hesek, Makana Steinmetz, Jackson D. Mills et autres

BACKGROUND: Traumatic arterial injuries are life-threatening if not surgically repaired. However, traditional suture repair can be complex, skill-dependent, time-consuming, and result in complications such as bleeding, aneurysm, occlusion, and stenosis. We present a novel bioabsorbable adhesive wrap that seals arterial defects after …

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Effect of Positioning on Work of Breathing and Oxygenation in Premature Infants at Discharge: A Prospective Observational Study

Kelley Kovatis, Amy Mackley, Shannon Traczykiewicz, Tariq Rahman et autres

INTRODUCTION: Premature infants are predisposed to respiratory failure. Body position impacts lung volumes and pulmonary function. Respiratory inductance plethysmography (RIP) measures thoracoabdominal motion and can provide objective, noninvasive diagnostic measurements of work of breathing (WOB) indices. The objective of this study was …

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Pathways and challenges in the clinical translational of radiopharmaceuticals for pediatric investigations

Erik Stauff, Heidi H. Kecskemethy, Thomas H. Shaffer, Reza Vali et autres

Radiopharmaceutical development and clinical translation face numerous scientific, ethical, and regulatory challenges, particularly within the pediatric population. Although molecular imaging holds significant promise for improving diagnosis and treatment across a spectrum of diseases, including pediatric-specific conditions like Kawasaki disease, autism spectrum disorders, …

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Liquid Lung Rest During Extracorporeal Life Support in a Porcine Model of Acute Lung Injury

David Blauvelt, Anne Hesek, Michael Golecki, Gianna M. Parrish et autres

Abstract Rationale In patients with severe lung injury, extracorporeal life support can enable lung rest, but the optimal strategy is unknown. Objective To compare liquid lung rest versus standard gas rest ventilation in a porcine model of acute lung injury and extracorporeal …

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A prospective observational study comparing the developmental changes in work of breathing indices and oxygen saturation of term and preterm infants at birth. Do premature infants compensate?

Thomas H. Shaffer, Amy Mackley, Shannon Traczykiewicz, Tariq Rahman et autres

Background Intrauterine lung development is a complex process. Little is known regarding developmental breathing patterns of infants from delivery to discharge. In this study, we analyze developmental changes in work of breathing indices and oxygen saturation between healthy preterm and term infants …

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Relationships between Pulmonary Function Testing and Polysomnography in Adolescents with Severe Obesity

Abigail Strang, Benjamin J. Crain, Linhda Nguyen, Jobayer Hossain et autres

Severe obesity (BMI ≥ 35 kg/m 2 or ≥ 120% of the 95% for age) is increasingly prevalent in adolescents and is associated with respiratory compromise including obstructive and restrictive lung disease and obstructive sleep apnea hypopnea syndrome (OSAHS). The prevalence of …

Cardiac output during flow-titrated high-flow nasal cannula support in a neonatal porcine model

Yosef Levenbrown, Anne Hesek, James P. Keith, Kelly Massa et autres

Background Neonates are more susceptible to acute respiratory failure than older children. It is unknown to what extent high-flow nasal cannula (HFNC) alters intrathoracic pressure (ITP), potentially decreasing cardiac output (CO) due to cardiopulmonary interactions. This study evaluated the impact of flow …

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Impact of Final Cardioplegia Flush, Del Nido vs Histidine-Tryptophan-Ketoglutarate Solution on OCS Heart Transplant Outcomes: Analysis of OCS Heart Perfusion Registry

Suguru Ohira, D. D'Alessandro, Mauricio A. Villavicencio, Peter J. Gruber et autres

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Comparison of stress-induced hemolysis in neonatal intravenous catheters: Theoretical and experimental analysis of shear stress, exposure time, and index of hemolysis

Gordon Y. Chang, Ellen A Kane, Giovanna Palermo Tye, Paul T. Fawcett et autres

BackgroundSeveral studies report hemolysis when packed red blood cells (PRBCs) are transfused through small-inner-diameter (ID) catheters using presence of biomarkers but do not address cause and amount of hemolysis. This study aims to determine the cause and index of hemolysis percent (IH%) …

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