Irina I. Faingold

Study of acute toxicity of γ-cyclodextrin nitrates in vivo

Yurii M. Mikhailov, Anna V. Darovskikh, Anastasia V. Smolina, Elena N. Klimanova et autres

Background. Cyclodextrins and their individual derivatives capable of forming inclusion complexes with poorly soluble physiologically active compounds, increasing their solubility in water and slowing down their metabolism, are used as carriers of various drugs. Previously, cyclodextrin nitrates (NCD) were first proposed by …

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Nanosized Curcumin Systems Based on Amphiphilic (Co)Polymers of N-Vinylpyrrolidone with (Di)Methacrylates and Their Antioxidant Activity

A. V. Smolina, Irina I. Faingold, Darya A. Poletaeva, K. R. Koroleva et autres

Abstract Based on original amphiphilic copolymers of N-vinylpyrrolidone with (di)methacrylates, water-soluble compositions containing up to 4.3% curcumin and forming stable nanoscale structures in aqueous media were obtained and characterized. It was shown that curcumin in most polymer matrices occurs in an amorphous …

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EPR Spectra and Antioxidant Activity of Gamma-Irradiated Papain

Sergey V. Tokarev, Irina I. Faingold, Darya A. Poletaeva, A. V. Smolina et autres

The structure and number of paramagnetic centers (PC) trapped in papain γ-irradiated with a dose of 50 to 2300 kGy have been studied using EPR spectroscopy. The radiation-chemical yield G ≈ 6 PC/100 eV during radiolysis at 77 K is six times …

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Influence of the nitrosyl iron complex with thiosulfate ligands on carbohydrate metabolism and lipid peroxidation parameters in mice with experimental diabetes mellitus

Darya A. Poletaeva, Yu. V. Soldatova, Anastasia V. Smolina, Tatyana E. Sashenkova et autres

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Inhibitory Activity of N- and S-Functionalized Monoterpene Diols Towards Monoamine Oxidases A and B

Alexandra V. Podturkina, Oleg V. Ardashov, Yu. V. Soldatova, Darya A. Poletaeva et autres

Monoamine oxidase B (MAO-B) inhibitors are widely used as part of combination drug therapy for Parkinson’s disease. As demonstrated in both in vitro and in vivo experiments, the monoterpenoid Prottremine and some of its derivatives exhibit high antiparkinsonian activity. In this study, …

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Redox-Active Compounds in the Therapy of Drug-Resistant Murine Leukemia P388 Strains

T. A. Raevskaya, Yu. V. Soldatova, С. А. Гончарова, Irina I. Faingold

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Influence of Fullerene–Ruboxyl Dyad on Markers of Mitochondrial Dysfunction In Vitro

Darya A. Poletaeva, Anastasia V. Smolina, V. N. Varfolomeev, N. N. Lashmanov et autres

Fullerene–ruboxyl dyad was studied as a promising hybrid nanostructure for biomedical applications. It was shown that fullerene–ruboxyl dyad effectively interacts with the liposomal membrane in the region of the polar heads of phospholipids and has pronounced antiradical properties in vitro studies. Fullerene–ruboxyl …

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Combining Experimental and Computational Methods to Produce Conjugates of Anticholinesterase and Antioxidant Pharmacophores with Linker Chemistries Affecting Biological Activities Related to Treatment of Alzheimer’s Disease

Галина Файвелевна Махаева, Надежда Владимировна Ковалева, Елена В. Рудакова, Natalia P. Boltneva et autres

Effective therapeutics for Alzheimer’s disease (AD) are in great demand worldwide. In our previous work, we responded to this need by synthesizing novel drug candidates consisting of 4-amino-2,3-polymethylenequinolines conjugated with butylated hydroxytoluene via fixed-length alkylimine or alkylamine linkers (spacers) and studying their …

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Redox-active compounds in the therapy of drug-resistant murine leukemia P388 strains

T. A. Raevskaya, U. V. Soldatova, С. А. Гончарова, Irina I. Faingold

Scientific bases of technologies for synthesis and safety of water-soluble nitrates of cyclodextrins for medicinal purposes

Yury M. Mikhailov, Anna V. Darovskikh, L. S. Barinova, Mikhail I. Vorozheikin et autres

A set of studies of nitrates α -, β - and γ -cyclodextrins with an extremely low nitrogen content was carried out in order to establish optimal conditions for their production, as well as to systematically substantiate the possibility of their safe …

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Cardioprotective Effect of 2-Ethyl-3-Hydroxy-6-Methylpyridinium 2-Nitroxysuccinate Against Adrenaline/Hydrocortisone-Induced Myocardial Ischemia in Mice: Modulation of Free-Radical Processes in Biomembranes and Monoamine Oxidase A Activity

Irina I. Faingold, Anastasia V. Smolina, Yulia V. Soldatova, Darya A. Poletaeva et autres

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Combining Experimental and Computational Methods to Produce Conjugates of Anticholinesterase and Antioxidant Pharmacophores with Linker Chemistries Affecting Biological Activities Related to Treatment of Alzheimer's Disease

Галина Файвелевна Махаева, Надежда Владимировна Ковалева, Елена В. Рудакова, Natalia P. Boltneva et autres

Effective therapeutics for Alzheimer's disease (AD) are in great demand worldwide. In our previous work, we responded to this need by synthesizing novel drug candidates consisting of 4-amino-2,3-polymethylenequinolines conjugated with butylated hydroxytoluene via fixed-length alkylimine or alkylamine linkers (spacers) and studying their …

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