Zhonglin Jiang

Decidual aging in recurrent pregnancy Loss: from regulating networks to therapeutic interventions

Yu Liu, Wenyan Shi, Zhonglin Jiang, Yujie Xu et autres

.The uterine decidua is a key component of the maternal-fetal interface, and its senescence may be an important contributing factor to recurrent pregnancy loss (RPL). Decidual senescence disrupts gestational homeostasis via cell cycle arrest, immune imbalance, and metabolic reprogramming, thereby potentially contributing …

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hUCMSCs restore ovarian function via angiopoietin 1/2 rebalance in POI rats

Qianqian Luo, Chengen Liu, Yongtao Su, Ranran Liu et autres

BACKGROUND: Premature ovarian insufficiency (POI) is often iatrogenic and the therapeutic potential of human umbilical cord derived mesenchymal stem cells (hUCMSCs) remain incompletely defined. This study aimed to evaluate the effects and underlying mechanism of hUCMSCs on ovarian function in a rat …

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MSC-derived exosomes improve endometrial fibrosis via the lncRNA IGF2R/ miR-143-5p/AQP8 axis

Xingyu Huo, Juntong Chen, Maojiao Qian, Qian Xue et autres

BACKGROUND: Endometrial injury (EI) is frequently associated with intrauterine adhesions, endometrial thinning, amenorrhea, and infertility. In recent years, stem cells and their exosomes have been shown to have significant tissue repair efficacy. However, the role and probable mechanism of human umbilical cord …

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hUMSCs restore ovarian function in POI mice by regulating GSK3β-mediated mitochondrial dynamic imbalances in theca cells

Yanlian Xiong, Yaru Si, Xingyu Huo, Juntong Chen et autres

Premature ovarian insufficiency (POI), a major cause of female infertility, is defined as follicular atresia and a rapid loss of germ cells in women of reproductive age due to ovarian failure. Recently, findings from several studies have indicated that human umbilical cord …

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hUMSCs Transplantation Regulates AMPK/NR4A1 Signaling Axis to Inhibit Ovarian Fibrosis in POI Rats

Linlu Cui, Hongchu Bao, Wen‐Qian Zhu, Yu Tang et autres

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hUCMSCs reduce theca interstitial cells apoptosis and restore ovarian function in premature ovarian insufficiency rats through regulating NR4A1-mediated mitochondrial mechanisms

Qianqian Luo, Yu Tang, Zhonglin Jiang, Hongchu Bao et autres

BACKGROUND: Human umbilical cord mesenchymal stem cells (hUCMSCs, retrospectively registered) have a lot of promise for treating theca interstitial cells(TICs) dysfunction in premature ovarian insufficiency (POI). The mechanisms, however, are still unknown. METHODS: To examine the therapeutic and find the cause, we …

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hUMSCs transplantation regulates AMPK/NR4A1 signaling axis to inhibit ovarian fibrosis in POI rats

Linlu Cui, Zhonglin Jiang, Wen‐Qian Zhu, Yu Tang et autres

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