Qian Xue

Subcellular transcriptome sequencing with single cell APEX-seq identifies regulators of cell-cell interactions

Andrew G. Xue, Bo Cai, Qian Xue, Nianping Liu et autres

Single-cell RNA sequencing has transformed our understanding of tissue complexity and heterogeneous cell states, yet provides little information about the subcellular organization of transcriptomes - despite the central role of RNA localization in splicing, translation, and function. Here we introduce single-cell APEX-seq …

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MSC-derived exosomes improve endometrial fibrosis via the lncRNA IGF2R/ miR-143-5p/AQP8 axis

Xingyu Huo, Juntong Chen, Maojiao Qian, Qian Xue et autres

BACKGROUND: Endometrial injury (EI) is frequently associated with intrauterine adhesions, endometrial thinning, amenorrhea, and infertility. In recent years, stem cells and their exosomes have been shown to have significant tissue repair efficacy. However, the role and probable mechanism of human umbilical cord …

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Exosomes Derived From Human Mesenchymal Stem Cells Mitigate Follicular Interstitial Cell Ferroptosis via the miR-26a-5p/PTEN/GPX4 Axis in Rats with Chemotherapy-Induced Premature Ovarian Insufficiency

Juntong Chen, Xingyu Huo, Maojiao Qian, Qian Xue et autres

Background: Premature ovarian insufficiency (POI) is a persistent condition in young women characterized by early follicular development disorders and reduced fertility. Research has found that exosomes derived from human umbilical mesenchymal stem cells (hUCMSC-Exo) have significant tissue repair effects. This study aims …

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Human CSPG4-targeting CAR-macrophages inhibit melanoma growth

Daniel Greiner, Qian Xue, Trinity Q Alaka’i Waddell, Elena Kurudza et autres

Approximately half of melanoma patients relapse or fail to respond to current standards of care, highlighting the need for new treatment options. Engineering T-cells with chimeric antigen receptors (CARs) has revolutionized the treatment of hematological malignancies but has been clinically less effective …

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CSPG4-targeting CAR-macrophages inhibit melanoma growth

Daniel Greiner, Qian Xue, Trinity Q Alaka’i Waddell, Elena Kurudza et autres

ABSTRACT Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of hematological malignancies but has been clinically less effective in solid tumors. Engineering macrophages with CARs has emerged as a promising approach to overcome some of the challenges faced by CAR-T …

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Abstract 5245: Anti-CSPG4 CAR-Macrophages synergize with anti-CD47 in melanoma cytotoxicity

Daniel Greiner, Qian Xue, Trinity Q Alaka’i Waddell, Minna Roh‐Johnson

Abstract While CAR T-cells have been a success in treating liquid tumors, these successes have not been replicated in solid tumors. There are several reasons for these challenges, including physical matrix barriers and increased tumor antigen heterogeneity in solid tumors. Macrophages are …

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Lack of Paxillin phosphorylation promotes single-cell migration in vivo

Qian Xue, Sophia R.S. Varady, Trinity Q Alaka’i Waddell, Mackenzie R. Roman et autres

Focal adhesions are structures that physically link the cell to the extracellular matrix for cell migration. Although cell culture studies have provided a wealth of information regarding focal adhesion biology, it is critical to understand how focal adhesions are dynamically regulated in …

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An evolutionary and physiological perspective on cell-substrate adhesion machinery for cell migration

Julio C. Fierro Morales, Qian Xue, Minna Roh‐Johnson

Cell-substrate adhesion is a critical aspect of many forms of cell migration. Cell adhesion to an extracellular matrix (ECM) generates traction forces necessary for efficient migration. One of the most well-studied structures cells use to adhere to the ECM is focal adhesions, …

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Focal adhesion-based cell migration is differentially regulated in vivo versus in vitro by Paxillin phosphorylation

Qian Xue, Sophia R.S. Varady, Trinity Q Alaka’i Waddell, James Carrington et autres

Summary Focal adhesions are important subcellular structures that physically link the cell to the extracellular matrix (ECM), thus facilitating efficient cell migration. Although in vitro cell culture studies have provided a wealth of information regarding focal adhesion biology, it is critical to …

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Sharing Is Caring

Qian Xue, Minna Roh‐Johnson

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