Pablo Cárdenas

Synthetic transcriptional control in the malaria parasite Plasmodium falciparum

Pablo Cárdenas, Sebastian Smick, Sumanta Dey, Jacquin C. Niles

Abstract Malaria is responsible for over half a million deaths each year. However, our understanding of malaria parasite biology is hampered by a lack of molecular tools, particularly at the level of transcriptional control. In light of this, we have created two …

us (code pays fourni par la source)

Treatment of STEC infection via CRISPR-Cas targeted cleavage of the Shiga toxin gene in animal models

Matthieu Galtier, Antonina O. Krawczyk, Fabien J. Fuche, Loïc H. Charpenay et autres

Abstract Escherichia coli is a ubiquitous gut commensal but also an opportunistic pathogen responsible for severe intestinal and extra-intestinal infections. Shiga toxin-producing E. coli (STEC) pose a significant public health threat, particularly in children, where infections can lead to bloody diarrhea and …

fr (code pays fourni par la source)

CRISPR-Cas spacer acquisition is a rare event in human gut microbiome

Anni Zhang, Jeffry M. Gaston, Pablo Cárdenas, Shijie Zhao et autres

Host-parasite relationships drive the evolution of both parties. In microbe-phage dynamics, CRISPR functions as an adaptive defense mechanism, updating immunity via spacer acquisition. Here, we investigated these interactions within the human gut microbiome, uncovering low frequencies of spacer acquisition at an average …

sg, us (code pays fourni par la source)

Using GAMA to run reinforcement learning simulations of disease spread including the effect of pathogen fitness

Winnie Wezi Mkandawire, Jacob Collins, Pablo Cárdenas, Andrés Colubri

International audience

us (code pays fourni par la source)

Resolving drug selection and migration in an inbred South American Plasmodium falciparum population with identity-by-descent analysis

Manuela Carrasquilla, Angela M. Early, Aimee R. Taylor, Angélica Knudson-Ospina et autres

The human malaria parasite Plasmodium falciparum is globally widespread, but its prevalence varies significantly between and even within countries. Most population genetic studies in P. falciparum focus on regions of high transmission where parasite populations are large and genetically diverse, such as …

us, co, gb, ec (code pays fourni par la source)

Using Big Data and Network Theory to Inform Decision-making on COVID-19 in Bogotá

Alejandro Feged-Rivadeneira, Felipe González-Casabianca, Andrea Parra‐Salazar, Juana Salcedo-Ortiz et autres

co, ca, us, bo, ve, es (code pays fourni par la source)

Genomic epidemiological models describe pathogen evolution across fitness valleys

Pablo Cárdenas, Vladimir Corredor, Mauricio Santos‐Vega

Genomics is fundamentally changing epidemiological research. However, systematically exploring hypotheses in pathogen evolution requires new modeling tools. Models intertwining pathogen epidemiology and genomic evolution can help understand processes such as the emergence of novel pathogen genotypes with higher transmissibility or resistance to …

us, co (code pays fourni par la source)

An engineered live biotherapeutic for the prevention of antibiotic-induced dysbiosis

Andrés Cubillos-Ruiz, Miguel A. Alcantar, Nina M. Donghia, Pablo Cárdenas et autres

us (code pays fourni par la source)

Resolving drug selection and migration in an inbred South American Plasmodium falciparum population with identity-by-descent analysis

Manuela Carrasquilla, Angela M. Early, Aimee R. Taylor, Angélica Knudson et autres

Abstract The human malaria parasite Plasmodium falciparum is globally widespread, but its prevalence varies significantly between and even within countries. Most population genetic studies in P. falciparum focus on regions of high transmission where parasite populations are large and genetically diverse, such …

us, co, gb, ec (code pays fourni par la source)

GeneTargeter: Automated In Silico Design for Genome Editing in the Malaria Parasite, Plasmodium falciparum

Pablo Cárdenas, Lisl Y. Esherick, Gaël Chambonnier, Sumanta Dey et autres

Functional characterization of the multitude of poorly described proteins in the human malarial pathogen, Plasmodium falciparum , requires tools to enable genome-scale perturbation studies. Here, we present GeneTargeter ( genetargeter.mit.edu ), a software tool for automating the design of homology-directed repair donor …

us (code pays fourni par la source)

Genomic epidemiological models describe pathogen evolution across fitness valleys

Pablo Cárdenas, Vladimir Corredor, Mauricio Santos‐Vega

Abstract Genomics is fundamentally changing epidemiological research. However, systematically exploring hypotheses in pathogen evolution requires new modeling tools. Models intertwining pathogen epidemiology and genomic evolution can help understand processes such as the emergence of novel pathogen genotypes with higher transmissibility or resistance …

us, co (code pays fourni par la source)

GeneTargeter: Automated in silico design for genome editing in the malaria parasite, Plasmodium falciparum

Pablo Cárdenas, Lisl Y. Esherick, Gaël Chambonnier, Sumanta Dey et autres

us (code pays fourni par la source)