Fabien J. Fuche

Treatment of Shiga toxin–producing E. coli infection by CRISPR-Cas–targeted cleavage of the Shiga toxin gene in animal models

Matthieu Galtier, Antonina O. Krawczyk, Fabien J. Fuche, Loïc H. Charpenay et autres

Escherichia coli is not only a ubiquitous gut commensal but also an opportunistic pathogen responsible for severe intestinal and extraintestinal infections. Shiga toxin–producing E. coli (STEC) poses a notable public health threat, particularly in children, where infections can lead to bloody diarrhea …

fr (code pays fourni par la source)

Treatment of STEC infection via CRISPR-Cas targeted cleavage of the Shiga toxin gene in animal models

Matthieu Galtier, Antonina O. Krawczyk, Fabien J. Fuche, Loïc H. Charpenay et autres

Abstract Escherichia coli is a ubiquitous gut commensal but also an opportunistic pathogen responsible for severe intestinal and extra-intestinal infections. Shiga toxin-producing E. coli (STEC) pose a significant public health threat, particularly in children, where infections can lead to bloody diarrhea and …

fr (code pays fourni par la source)

In situ targeted base editing of bacteria in the mouse gut

Andreas K. Brödel, Loïc H. Charpenay, Matthieu Galtier, Fabien J. Fuche et autres

Abstract Microbiome research is now demonstrating a growing number of bacterial strains and genes that affect our health 1 . Although CRISPR-derived tools have shown great success in editing disease-driving genes in human cells 2 , we currently lack the tools to …

fr (code pays fourni par la source)

In situ targeted mutagenesis of gut bacteria

Andreas K. Brödel, Loïc H. Charpenay, Matthieu Galtier, Fabien J. Fuche et autres

Abstract Microbiome research is revealing a growing number of bacterial genes that impact our health. While CRISPR-derived tools have shown great success in editing disease-driving genes in human cells, we currently lack the tools to achieve comparable success for bacterial targets. Here …

fr (code pays fourni par la source)

Refinement of a Live Attenuated Salmonella enterica Serovar Newport Vaccine with Improved Safety

Shamima Nasrin, Fabien J. Fuche, Khandra T. Sears, Jennifer A. Jones et autres

Non-typhoidal Salmonella (NTS) is a major cause of gastroenteritis and is responsible for approximately 93 million cases annually. In healthy individuals, gastroenteritis caused by NTS is usually self-limiting, however, NTS can cause severe invasive disease in immunocompromised patients. Very little research has …

us (code pays fourni par la source)

Deletions inguaBAandhtrAbut notclpXorrfaLconstitute a live-attenuated vaccine strain ofSalmonellaNewport to protect against serogroup C2-C3Salmonellain mice

Fabien J. Fuche, Jennifer A. Jones, Girish Menon Ramachandran, Ellen E. Higginson et autres

Non-typhoidal Salmonella (NTS) are a leading cause of foodborne infections worldwide, and serogroups B, C1, C2-C3 and D are the most common serogroups associated with human disease. While live vaccine candidates that protect against S. Typhimurium (serogroup B) and S. Enteritidis (serogroup …

us (code pays fourni par la source)

Immunogenicity and protective efficacy against Salmonella C2-C3 infection in mice immunized with a glycoconjugate of S. Newport Core-O polysaccharide linked to the homologous serovar FliC protein

Ofir Schuster, Khandra T. Sears, Girish Menon Ramachandran, Fabien J. Fuche et autres

Nontyphoidal Salmonella (NTS) are important human enteric pathogens globally. Among the different serovars associated with human NTS disease, S. Newport (a serogroup C2-C3 Salmonella) accounts for a measurable proportion of cases. However, to date there are no licensed human NTS vaccines. NTS …

il, us (code pays fourni par la source)

Characterization of Invasive Salmonella Serogroup C1 Infections in Mali

Fabien J. Fuche, Sunil Kumar Sen, Jennifer A. Jones, Joseph Nkeze et autres

Nontyphoidal Salmonella (NTS) are the leading cause of foodborne infections worldwide and a major cause of bloodstream infections in infants and HIV-infected adults in sub-Saharan Africa (SSA). Salmonella Typhimurium (serogroup B) and Salmonella Enteritidis (serogroup D) are the most common serovars in …

us, Mali (code pays fourni par la source)

Salmonella Serogroup C: Current Status of Vaccines and Why They Are Needed

Fabien J. Fuche, Ousmane Sow, Raphael Simon, Sharon M. Tennant

Nontyphoidal Salmonella (NTS; i.e., Salmonella enterica organisms that do not cause typhoid or paratyphoid) are responsible for 94 million infections and 155,000 deaths worldwide annually, 86% of which are estimated to be foodborne. Although more than 50 serogroups and 2,600 serovars have …

us (code pays fourni par la source)

Functional Type 1 Secretion System Involved in Legionella pneumophila Virulence

Fabien J. Fuche, Anne Vianney, Claire Andréa, Patricia Doublet et autres

Legionella pneumophila is a Gram-negative pathogen found mainly in water, either in a free-living form or within infected protozoans, where it replicates. This bacterium can also infect humans by inhalation of contaminated aerosols, causing a severe form of pneumonia called legionellosis or …

fr (code pays fourni par la source)

Rôle des pompes à efflux et du système de sécrétion de type I dans la résistance et la virulence de Legionella pneumophila

Fabien J. Fuche

Legionella pneumophila est une bactérie gram/négative de l'environnement qui infecte et se multiplie au sein des protozoaires aquatiques, comme les amibes. Elle peut également infecter les macrophages pulmonaires humains, causant une forme sévère de pneumonie appelée légionellose (ou maladie du légionnaire). L'importance …

fr (code pays fourni par la source)

Molecular mimicry and original biochemical strategies for the biogenesis of a Legionella pneumophila replicative niche in phagocytic cells

Julie Allombert, Fabien J. Fuche, Céline Michard, Patricia Doublet

fr (code pays fourni par la source)