Adam Gądek

Radiobiological Effects of Low-Dose Radiation in Normal Fibroblasts of Patients with Head and Neck Cancer Treated with Induction Chemotherapy Combined with Low-Dose Fractionated Radiation

Gabriela Winiarska, Tomasz Rutkowski, Adam Gądek, Wojciech Fidyk et autres

The aim of the study was to define radiobiological effects of single and fractionated low doses in normal fibroblasts in 40 patients with squamous cell carcinoma of the head and neck (HNSCC) treated with induction chemotherapy combined with low-dose fractionated radiation (LDFR) …

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Proteomic Profiling of Cardiomyocytes Revealed Potential Radioprotective Effects of Different Resveratrol Pretreatment Regimens

Michalina Gramatyka, Marta Gawin, Agata Kurczyk, Adam Gądek et autres

Resveratrol may protect against radiation by modulating cellular metabolism and enhancing the cellular response to stress. Here, we explored its effects on human cardiomyocytes exposed to ionizing radiation. Resveratrol (5 µM) was administered for 1, 7, and 30 days before a single …

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Zastosowanie opcji DirectDensity w planowaniu rozkładu dawki

Maciej Giza, Adam Gądek, Łukasz Sroka, Aleksandra Masternak et autres

Tomografia komputerowa jest bardzo istotnym elementem radioterapii. Obraz z tego badania jest wykorzystywany w celu wrysowania obszaru tarczowego oraz narządów krytycznych, jak również przeprowadzenia obliczeń rozkładu dawki w celach terapeutycznych. Jednak aby system planowania leczenia mógł dokonać niezbędnych obliczeń, trzeba powiązać jednostki …

Klasyczne i nowoczesne protezy w kontekście rozkładu dawki u pacjentów leczonych onkologicznie – praca przeglądowa

Olga Zawarczyńska, Krzysztof Jagla, Maciej Giza, Adam Gądek et autres

W ostatnich latach można zauważyć prężny rozwój w naukach stosowanych, który bezpośrednio przekłada się na sektor medyczny. Coraz częściej oprogramowanie oraz sprzęty medyczne wykorzystywane w szpitalach opierają się na sztucznej inteligencji i bardziej zaawansowanych podzespołach. Jedną z technologii umożliwiających znaczny skok w …

175 Induction radiochemotherapy with low dose fractionation XRT in patients with advanced HNSCC.

Urszula Kacorzyk, Marek Kentnowski, Katarzyna Drosik‐Rutowicz, Dorota Słonina et autres

Comparison of EPID portal dosimetry verification and RadCalc dose verification for VMAT treatment plans

Adam Gądek, Dominika Plaza, Łukasz Sroka, Marta Reudelsdorf et autres

Introduction. Dosimetry verification is required before starting each treatment. The legal regulations do not clearly define one method of plan verification. Therefore, it is allowed to perform measurements (electronic portal imaging device [EPID]) or calculations using an independent system. Portal dosimetry using …

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Low-Dose Radiotherapy for Patients with Pneumonia Due to COVID-19: A Single-Institution Prospective Study

Tomasz Rutkowski, Jerzy Jaroszewicz, Damian Piotrowski, Krzysztof Ślosarek et autres

Purpose: Results of the low-dose radiation therapy (LDRT) in patients with pneumonia due to COVID-19 has been presented. Methods: Fifteen patients received a single-fraction radiation dose of 1 Gy to the bilateral lungs due to pre-ARDS pneumonia in the course of COVID-19. …

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Influence of optional measurement parameters in the Eclipse treatment planning system on the quality of the dosimetric model of the biomedical accelerator using the Acuros XB algorithm

Adam Gądek, Jacek Wendykier, Aleksandra Grządziel, B. Bekman et autres

Background: To properly configure a treatment planning system, a measurement data set is needed, which consists of the values required for its configuration. The aim is to obtain a dosimetric model of the beam that is as compatible as possible with the …

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Dose estimation in patients treated with radiotherapy for SARS-COVID disease based on EPID measurement

Krzysztof Ślosarek, Tomasz Rutkowski, Adam Gądek, Łukasz Sroka et autres

Introduction. COVID radiotherapy requires performance of all radiotherapy (RT) procedures during one site visit due to the infectious nature of the disease. The aim of the study was to develop methods of estimating the delivered dose based on electronic portal image device …

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Lung volume irradiation procedures in patients with pneumonia during COVID-19 infection – physical aspects of treatment planning and dosimetry

Krzysztof Ślosarek, Adam Gądek, Łukasz Sroka, Łukasz Dolla et autres

Introduction. The paper presents an original, used in our Institute, method of lung volume irradiation in patients with pneumonia during COVID-19 infection. Material and methods. Procedures such as the simulation of treatment and radiotherapy are performed in a treatment room. Real time …

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Synthetic CT in assessment of anatomical and dosimetric variations in radiotherapy - procedure validation

Aleksandra Grządziel, Adam Gądek, B. Bekman, Jacek Wendykier et autres

Abstract Introduction: One of many procedures to control the quality of radiotherapy is daily imaging of the patient’s anatomy. The CBCT (Cone Beam Computed Tomography) plays an important role in patient positioning, and dose delivery monitoring. Nowadays, CBCT is a baseline for …

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Application of aqueous hydrazine solution for beta-elimination of O-glycans from gastric mucin.

Dariusz G. Kisiel, A Gindzieński, Adam Gądek

O-Glycans from pig gastric mucin were released by beta-elimination in 0.2 M triethylamine and 50% aqueous hydrazine solution. The released glycan hydrazides were isolated using Centricon 10 separators, brought to their reducing form and reductive by labelled with p-aminobenzoic acid ethyl ester …

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