Ushio Aya

Molecular Pathogenesis via Sex Hormone in Sjögren's Syndrome

Ushio Aya, Naozumi Ishimaru

A lot of autoimmune diseases are known to develop in postmenopausal women. However, the mechanisms by which estrogen deficiency influences the onset or development of autoimmunity remain unclear. Sjögren's syndrome (SS) is characterized by a 9 : 1 ratio of women/men. In …

Functionally diverse thymic medullary epithelial cells interplay to direct central tolerance

Ushio Aya, Mami Matsuda‐Lennikov, Felix Kalle-Youngoue, Akihide Shimizu et autres

Medullary thymic epithelial cells (mTECs) are essential for the establishment of self-tolerance in T cells. Promiscuous gene expression by a subpopulation of mTECs regulated by the nuclear protein Aire contributes to the display of self-genomic products to newly generated T cells. Recent …

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The thymoproteasome hardwires the TCR repertoire of CD8+ T cells in the cortex independent of negative selection

Izumi Ohigashi, Melina Frantzeskakis, Alison Jacques, Sayumi Fujimori et autres

The thymoproteasome expressed specifically in thymic cortical epithelium optimizes the generation of CD8+ T cells; however, how the thymoproteasome contributes to CD8+ T cell development is unclear. Here, we show that the thymoproteasome shapes the TCR repertoire directly in cortical thymocytes before …

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A novel method for measuring small amounts of saliva in mice

Rieko Arakaki, Ushio Aya, Kunihiro Otsuka, Yasusei Kudo et autres

Abstract Dry mouth is caused by the dysfunction of salivary glands due to various factors. In order to understand the mechanism of dry mouth or develop new therapies for dry mouth, many mice models have been widely used to analyze the function …

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Effect of multi-wall carbon nanotube exposure on pulmonary immune cells at the early stage

Mami Sato, Rieko Arakaki, Ushio Aya, Yasusei Kudo et autres

Long-term polarization of alveolar macrophages to a profibrotic phenotype after inhalation exposure to multi-wall carbon nanotubes

Kunihiro Otsuka, Koichi Yamada, Yuhji Taquahashi, Rieko Arakaki et autres

BACKGROUND: Nanomaterials are widely used in various fields. Although the toxicity of carbon nanotubes (CNTs) in pulmonary tissues has been demonstrated, the toxicological effect of CNTs on the immune system in the lung remains unclear. METHODS AND FINDING: In this study, exposure …

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The role of the cleaved form IL-33 in pathogenesis of Sjoegren’s syndrome (SS)

Rieko Arakaki, Nakayama Shinichiro, Ushio Aya, Kunihiro Otsuka et autres

A crucial role of follicular helper T cells in autoimmunity of a mouse model for Sjoegren’s syndrome

Kunihiro Otsuka, Yamada Akiko, Masako Saitō, Ushio Aya et autres

Chromosome Passenger Complex構成因子Borealinの細胞周期依存的なタンパク分解とその癌化への関与

Takaaki Tsunematsu, Yasusei Kudo, Tomoyuki Kondo, Kunihiro Otsuka et autres