Ai Zhuang

Comparative Proteomic Profiling of Microdissected Spindle and Epithelioid Uveal Melanoma Subtypes

Yu Luan, Jieling Tang, Tianyu Zhu, Xiang Gu et autres

Purpose: Uveal melanoma (UM), the most prevalent primary intraocular cancer in adults, is defined by salient histopathological diversity. Spindle and epithelioid cells constitute its two dominant pathological lineages, yet the latter foreshadows aggressive behavior and shortened survival. This study aimed to explore …

cn (code pays fourni par la source)

Association between the oxidative balance score and risk of microvascular complications in type 2 diabetes: A prospective UK biobank cohort study

Jianping Hu, Tongxin Ge, Qiuyi Zhu, Yiran Yao et autres

AIMS: Oxidative stress contributes to diabetic microvascular complications (DMCs). This study investigated the association between lifestyle-associated oxidative stress and the risk of DMCs in patients with type 2 diabetes (T2D). MATERIALS AND METHODS: Our prospective study analysed data from 5635 individuals with …

cn, mo (code pays fourni par la source)

Author response for "Association between the Oxidative Balance Score and Risk of Microvascular Complications in Type 2 Diabetes: A Prospective UK Biobank Cohort Study"

Jianping Hu, Tongxin Ge, Qiuyi Zhu, Yiran Yao et autres

Effects of anti-CD19 CAR-T cells in a murine model of IgG4-related disease

Jianping Hu, Y e Yu, Yidi Yang, Yiyi Feng et autres

BACKGROUND: Chimeric antigen receptor T-cell (CAR-T) therapy, an emerging immunotherapy, has shown promising efficacy in several autoimmune diseases. In this study, we conducted a preclinical evaluation of the therapeutic potential of CD19-specific CAR-T cell–mediated B-cell depletion in a mouse model that recapitulates …

cn (code pays fourni par la source)

Advance of different strategies to achieve radiosensitivity based on nanomaterials

Aimin Chu, W. J. Zhang, Mengyao Li, Qiuyi Zhu et autres

Radiotherapy (RT) stands as one of the most widely used and effective modalities in the clinical treatment of malignant tumors. A key advancement in modern precision RT technology is to improve therapeutic gain ratios through physical techniques. However, RT efficacy remains constrained …

cn (code pays fourni par la source)

Tumor-intrinsic redox programming drives an SPP1-CD44 axis of immune suppression in uveal melanoma

Tongxin Ge, Yun Yang, Wenyue Zhang, Man Li et autres

Uveal melanoma (UM) is a rare yet aggressive malignancy with a high propensity for distant metastasis and poor response to systemic therapies, including immunotherapies. Although recent single-cell studies have uncovered pronounced intratumoral heterogeneity and an immunosuppressive tumor microenvironment, the tumor-intrinsic metabolic programs …

cn (code pays fourni par la source)

Author response for "Association between the Oxidative Balance Score and Risk of Microvascular Complications in Type 2 Diabetes: A Prospective UK Biobank Cohort Study"

Jianping Hu, Tongxin Ge, Qiuyi Zhu, Yiran Yao et autres

Effects of Anti-CD19 CAR-T Cells in a Murine Model of IgG4- Related Disease

Jianping Hu, Yu Yu, Yidi Yang, Yiyi Feng et autres

cn (code pays fourni par la source)

An ingenious suprachoroidal injector based on the resistance feedback theory for treatment of macular edema: A short-term pilot study

Qiuyi Zhu, Ai Zhuang, Dongqing Zhu

PurposeTo explore a new suprachoroidal space (SCS) injection technique using an ingenious, handmade, and precise suprachoroidal injector based on the resistance feedback theory to treat recurrent macular edema.MethodsWe designed a suprachoroidal injector on the basis of the resistance feedback theory and fabricated …

cn (code pays fourni par la source)

Epigenetic reprogramming holds promise in enhancing anti-tumor efficacy of CAR T cell therapy

Yue Zheng, Qiuyi Zhu, Xiaoran Li, Tongxin Ge et autres

cn (code pays fourni par la source)

Super-enhancers orchestrate transcriptional dysregulation and metabolic reprogramming in uveal melanoma

Hui Pan, Weihuan Shao, Huixue Wang, Shengfang Ge et autres

Uveal melanoma (UM) is the most common intraocular malignancy in adults and frequently metastasizes. Somatic mutations and chromatin aberrations have been implicated in the pathogenesis of this deadly disease. Despite rapid progress in elucidating the genetic landscape of UM, the epigenetic architecture …

cn (code pays fourni par la source)

Artemisinin synergizes with CCCP in autophagic cell death induction via ER stress in uveal melanoma

Minyue Xie, Xiang Gu, Zheng Qing Zhao, Yu Hua et autres

. Specifically, the combination of DHA and CCCP, a representative mitochondrial uncoupler, induced endoplasmic reticulum (ER) stress by enhancing the binding of ATF4 and CHOP to the SESN2 promoter region. This ER stress subsequently activated autophagic cell death, augmenting UM cell eradication. …

cn (code pays fourni par la source)