Effects of anti-CD19 CAR-T cells in a murine model of IgG4-related disease
Rattachement africain : cn. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Chimeric antigen receptor T-cell (CAR-T) therapy, an emerging immunotherapy, has shown promising efficacy in several autoimmune diseases. In this study, we conducted a preclinical evaluation of the therapeutic potential of CD19-specific CAR-T cell–mediated B-cell depletion in a mouse model that recapitulates key features of human IgG4-related disease (IgG4-RD). METHODS: B cell depletion strategies were evaluated in the LatY136F mouse model, a spontaneous murine model of IgG4-RD. Anti-CD19 CAR-T cells or control cells were transferred into LatY136F mice pretreated with total body irradiation. LatY136F mice treated with anti-CD20 monoclonal antibodies (mAb) served as the positive control group. RESULTS: CD19-targeted CAR-T cell infusion resulted in a more profound depletion of B cells and plasmablasts compared to anti-CD20 mAb treatment. This depletion was observed in peripheral blood, spleen, lacrimal glands, lungs, and pancreas in LatY136F mice. Moreover, CAR-T cell therapy significantly prolonged the survival of LatY136F mice and improved clinical symptoms compared to anti-CD20 mAb treatment. However, while CAR-T cell therapy reduced inflammation and fibrosis in the lacrimal glands and pancreas, it did not improve these conditions in the lungs. CONCLUSIONS: Our findings demonstrate that anti-CD19 CAR-T therapy effectively alleviates the progression of IgG4-RD, showing superior efficacy compared to anti-CD20 mAb in this preclinical model. These results support further investigation of CAR-T cells as a potential therapeutic option for IgG4-RD patients, with attention to potential adverse effects.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Effects of anti-CD19 CAR-T cells in a murine model of IgG4-related disease
- Date Crossref
- 26/01/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Shanghai Ninth People's Hospital pays non établi dans la noticeÉtablissement de santé
-
Shanghai Institute of Hematology pays non établi dans la noticeStructure de recherche
-
Second Affiliated Hospital of Zhejiang University pays non établi dans la noticeÉtablissement de santé
-
Renji Hospital pays non établi dans la noticeÉtablissement de santé
-
Shanghai Jiao Tong University School of Medicine Department of Ophthalmology pays non établi dans la noticeUniversité ou école supérieure
-
Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology pays non établi dans la noticeStructure de recherche
Shanghai Ninth People's Hospital, Shanghai Institute of Hematology et Second Affiliated Hospital of Zhejiang University, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.