Philip Tinnefeld

Localization of Apicomplexa Motor Myosin A with Axial Nanometric Precision Using Graphene Energy Transfer

Giovanni Ferrari, Yuan Song, Michael Hensel, Olympia Ekaterini Psathaki et autres

Apicomplexan parasites exhibit gliding motility, a fast locomotion mode, yet the precise localization of the migration motor myosin A (MyoA) remains unresolved because of limitations in light microscopy axial resolution, leading to two competing models: one placing MyoA in the cytoplasm and …

de (code pays fourni par la source)

Source data for "Graphene Energy Transfer Resolves Sub-Microsecond DNA Dynamics at the Single-Molecule Level"

Lars Richter, John F. Hartmann, Leo Christanell, Tim Schröder et autres

de, ar (code pays fourni par la source)

Source data for "Graphene Energy Transfer Resolves Sub-Microsecond DNA Dynamics at the Single-Molecule Level"

Lars Richter, John F. Hartmann, Leo Christanell, Tim Schröder et autres

de, ar (code pays fourni par la source)

Source data for "Graphene Energy Transfer Resolves Sub-Microsecond DNA Dynamics at the Single-Molecule Level"

Lars Richter, John F. Hartmann, Leo Christanell, Tim Schröder et autres

de, ar (code pays fourni par la source)

Transparent Graphene Interfaces for Capacitive Recordings from hiPSC-Derived Cardiomyocyte Monolayers: A Proof-of-Concept Study

Melanie Meincke, Andre Bazzone, Sonja Stoelzle‐Feix, Stephan Holzhauser et autres

Transparent conductive interfaces can enable optical pre-assessment of cardiac cell layers while remaining compatible with label-free electrophysiological recording. Here, we evaluated the integration of a monolayer graphene electrode into a capacitive recording platform for the analysis of human-induced pluripotent stem cell-derived cardiomyocyte …

de (code pays fourni par la source)

A generalizable interface-seeded framework for de novo design of functional oligomers

Ho Yeung Chim, Mubarak Olanrewaju Idris, D. L. RIEGER, Phillip Schlegel et autres

Abstract Protein oligomers are ubiquitous in biological systems and essential for function. However, the de novo design of oligomers that controllably assemble in response to exogenous stimuli remains challenging. Here, we present an AI-based generative approach that leverages an interface-seeded strategy for …

de, ch (code pays fourni par la source)

Resolving Sub-Microsecond Conformational Dynamics of Vertical Nucleic Acids on Graphene

Lars Richter, John F. Hartmann, Leo Christanell, Tim Schröder et autres

Abstract The function of nucleic acids is governed not only by their structure but also by their dynamics. At the molecular scale, transitions between functional structural states are superimposed on rapid thermal fluctuations, resulting in an intricate interplay that is challenging to …

de, ar (code pays fourni par la source)

Modulation of Single-Molecule Emission at Hexagonal Boron Nitride Surfaces

Daria Orekhova, Rui Wang, Ze Yu, Jakob Hartmann et autres

Hexagonal boron nitride (hBN) is gaining increasing attention in the field of biomolecule characterization due to its compatibility with single-molecule fluorescence imaging and real-time tracking. Embedding fluorescent molecules within hBN layers offers potential for molecular-resolution sensing devices, since these probes are highly …

nl, de, jp (code pays fourni par la source)

DNA‐Based Exciton Collider to Monitor Exciton Diffusion and Annihilation

Tim Schröder, Philipp Wutz, John M. Lupton, Philip Tinnefeld et autres

DNA‐based nanoscale architectures provide an attractive bottom‐up alternative to lithographic approaches for photonic device fabrication, offering molecular precision, intrinsic scalability, and biocompatibility. Here, we exploit these advantages to construct one‐dimensional photonic wires using DNA origami with up to nine precisely positioned organic …

de (code pays fourni par la source)

Distance‐Dependent Energy Transfer Between Organic Fluorophores and Single‐Walled Carbon Nanotubes

Izabela Kamińska, Justus T. Metternich, Alan M. Szalai, Carolin Smidoda et autres

ABSTRACT Single‐walled carbon nanotubes (SWCNTs) are promising optical biosensing platforms due to their intrinsic near‐infrared fluorescence and environmental sensitivity. While DNA‐SWCNT hybrids have been widely studied, the structural arrangement of double‐stranded DNA (dsDNA) on SWCNTs and its impact on exciton–fluorophore interactions remain …

de, pl, ar, us (code pays fourni par la source)

Polymer dots for nanoscale live-cell imaging

Philip Tinnefeld, Samrat Basak

de (code pays fourni par la source)

Open-source sub-nanometer stabilization system for super-resolution fluorescence microscopy

Florencia Edorna, Florencia D. Choque, Giovanni M. Ferrari, Luciano A. Masullo et autres

Recent advances in fluorescence nanoscopy have pushed resolution to the 1-10 nm range, enabling the direct visualization of individual molecules even in crowded biological environments. Achieving this level of precision requires rigorous sample drift control. Techniques such as MINFLUX and RASTMIN, which …

ar, de, pl, ch (code pays fourni par la source)