Runping Su

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu et autres

ABSTRACT The immunosuppressive microenvironment limits immunotherapy in triple‐negative breast cancer (TNBC). Interleukin‐15 (IL‐15) activates cytotoxic lymphocytes but is limited by rapid clearance and poor tumor retention. Here, we developed an oncolytic adenovirus encoding IL15C‐CBD, an immunocytokine comprising an IL‐15/IL‐15Rα sushi‐domain complex fused …

cn, us (code pays fourni par la source)

Integrating CD45 + CD3+ and CD3 + CD8+ T-cell markers into nomograms for predicting survival in gastroesophageal junction carcinoma

Yubao Song, Zhixiang Wang, J F Ma, Y Li et autres

To develop and validate prognostic nomograms for overall (OS) and progression-free survival (PFS) in gastroesophageal junction (GEJ) carcinoma to enable risk-stratified clinical decision-making. In this retrospective study of 618 patients, prognostic factors were selected using LASSO regression. Nomograms were constructed and validated …

cn (code pays fourni par la source)

826 GUT MUCOSAL VIROME ENTEROTYPES IN CROHN’S DISEASE AND THEIR COMPOSITIONAL VARIATIONS DETERMINE INTESTINAL INFLAMMATION SEVERITY

Weijie Wen, Runping Su, Ziyu Huang, Zhiyang Feng et autres

826 GUT MUCOSAL VIROME ENTEROTYPES IN CROHN’S DISEASE AND THEIR COMPOSITIONAL VARIATIONS DETERMINE INTESTINAL INFLAMMATION SEVERITY

Weijie Wen, Runping Su, Ziyu Huang, Zhiyang Feng et autres

Gut DNA virome enterotype dictates inflammation heterogeneity through tuning the phage-bacteria-sphingosine-intestine axis in Crohn's disease

Weijie Wen, Runping Su, Yunyun Liu, Zhiyang Feng et autres

cn, au (code pays fourni par la source)

Publisher Correction: Gut mucosal mycobiome profiling in Crohn’s disease uncovers an AMP-mediated anti-inflammatory effect of Cladosporium sphaerospermum

Ziyu Huang, Yunyun Liu, Yelin Wu, Feng Zhang et autres

cn, de, au (code pays fourni par la source)

Gut mucosal mycobiome profiling in Crohn’s disease uncovers an AMP-mediated anti-inflammatory effect of Cladosporium sphaerospermum

Ziyu Huang, Yunyun Liu, Yinyin Wu, Feng Zhang et autres

cn, de, au (code pays fourni par la source)

Glutarimide-derived ionizable lipid enables mRNA lipid nanoparticle vaccines with enhanced safety and immunogenicity

Sha Li, Lu Hai Zheng, Zixuan Zhang, Jianhua Zhang et autres

cn, kn (code pays fourni par la source)

1287: DIETARY WHEY PROTEIN REGULATES THE GUT PHAGEOMEBACTERIOME TRANSKINGDOM INTERACTION DYNAMICS TO ATTENUATE INTESTINAL INFLAMMATION IN CROHN’S DISEASE

Runping Su, Weijie Wen, Yufeng Jin, Zhiyang Feng et autres

Dietary whey protein protects against Crohn’s disease by orchestrating cross-kingdom interaction between the gut phageome and bacteriome

Runping Su, Weijie Wen, Yufeng Jin, Zhirui Cao et autres

Background The gut microbiome and diet are important factors in the pathogenesis and management of Crohn’s disease (CD). However, the role of the gut phageome under dietary influences is unknown. Objective We aim to explore the effect of diet on the gut …

cn, pl (code pays fourni par la source)

Enhancing Immune Responses Through Modulation of Innate Cell Microenvironments in Lymph Nodes with Virus‐Mimetic Vaccines

Runping Su, Tingting Yao, Chong Cao, Yaqi Yang et autres

Abstract Nanovaccines hold significant promise for the prevention and treatment of infectious diseases. However, the efficacy of many nanovaccines is often limited by inadequate stimulation of both innate and adaptive immune responses. Herein, we explore a rational vaccine strategy aimed at modulating …

cn (code pays fourni par la source)

Enhancing Immune Responses Through Modulation of Innate Cell Microenvironments in Lymph Nodes with Virus‐Mimetic Vaccines

Runping Su, Tingting Yao, Chong Cao, Yaqi Yang et autres

Abstract Nanovaccines hold significant promise for the prevention and treatment of infectious diseases. However, the efficacy of many nanovaccines is often limited by inadequate stimulation of both innate and adaptive immune responses. Herein, we explore a rational vaccine strategy aimed at modulating …

cn (code pays fourni par la source)