J F Ma

Fabrication of paclitaxel loaded PLA/PCN-224 metal-organic framework for targeted high-intensity focused ultrasound driven sonodynamic therapy on hypoxia alleviated liver cancer cells

Rong Yang, Yongjing Chen, J F Ma, Yushan Zhao et autres

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T320 tissue factor-targeted ADC from pre-clinical research to phase I clinical study.

Yue Yu, Hao Yuan, Yi Zhao, Hua Hao et autres

e15032 Background: Tissue factor (TF) is highly expressed in various malignant tumors, including pancreatic, cervical, lung, and esophageal cancers, while being minimally expressed in normal tissues. T320 is a novel antibody-drug conjugate (ADC) consisting of a TF-targeting humanized monoclonal IgG1 conjugated with …

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Updated efficacy results from the phase I cervical cancer cohort of BAT8008, a TROP-2–directed antibody-drug conjugate, in patients with advanced cervical cancer.

J S Zhao, Wenjuan Chen, M Zhang, Y Li et autres

5507 Background: BAT8008 is a novel antibody-drug conjugate comprising a TROP-2 antibody and an exatecan payload. Patients with recurrent or metastatic cervical cancer (r/m CC) who have progressed on platinum-based chemotherapy have limited treatment options and poor prognosis. This study reports the …

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Integrating CD45 + CD3+ and CD3 + CD8+ T-cell markers into nomograms for predicting survival in gastroesophageal junction carcinoma

Yubao Song, Zhixiang Wang, J F Ma, Y Li et autres

To develop and validate prognostic nomograms for overall (OS) and progression-free survival (PFS) in gastroesophageal junction (GEJ) carcinoma to enable risk-stratified clinical decision-making. In this retrospective study of 618 patients, prognostic factors were selected using LASSO regression. Nomograms were constructed and validated …

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[A real-world study of 15,644 patients undergoing D2 radical gastrectomy over 11 years at Shanxi provincial cancer hospital].

Binghua Jiao, Kai Xiong Tao, Guangju Zhai, Ziqing Gao et autres

Gastric cancer in Shanxi Province is characterized by a male predominance, a high prevalence of tumors at the esophagogastric junction, a large proportion of poorly differentiated adenocarcinoma, and presentation at advanced stages (predominantly Stage III). The detection rate of early gastric cancer …

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[Clinical observation on the anthracyclines-induced cardiotoxicity in patients with early-stage breast cancer].

Guangxia Hu, H X Fu, J F Ma, Meiling Hu et autres

Patients with early-stage breast cancer after surgery could tolerate the anthracyclines-induced cardiotoxicity. Three chemotherapy schemes of ACT, FAC and EC, especially the EC protocol, could affect the myocardial damage. However, outcome is comparable among patients treated with above chemotherapy schemes in this …

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[Outcome determinants in cardiac arrest patients secondary to acute myocardial infarction receiving extra-corporeal membrane oxygenation combined with percutaneous coronary intervention therapy].

Huaying Fu, J F Ma, Meirong Hu, Zizhou Zhao et autres

ECMO combined with emergency PCI can improve the success rate of traditional cardiopulmonary resuscitation in patients with cardiac arrest secondary to acute myocardial infarction. Left anterior descending artery lesion, number of lesion vessels, traditional cardiopulmonary resuscitation time, time interval between cardiac arrest …

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HISTOLOGICAL GRADING OF ORAL CANCER: A COMPARISON OF DIFFERENT SYSTEMS AND THEIR RELATION TO LYMPH NODE METASTASIS

Doshi Neena P, Shah Siddharth A, Patel Keyuri B, J F Ma et autres

Oral squamous cell carcinoma has a great predisposition to produce metastasis in lymph nodes. In clinical practice, the treatment plan and prognosis of oral squamous cell carcinoma is mainly based on the primary tumor, regional lymph node metastasis, and distant metastasis (TNM) …