Pengbo Hou

Imaging Mass Cytometry Dataset of Human Carotid Atherosclerotic Plaques

Pengbo Hou

Overview This repository contains de-identified raw and processed imaging mass cytometry (IMC) data supporting the study entitled “Spatial Single-Cell Proteomics Identifies Macrophage Niches Driving Human Carotid Plaque Instability.” The repository includes pixel-level raw IMC acquisition data, processed multichannel images, cell-segmentation masks, extracted …

Imaging Mass Cytometry Dataset of Human Carotid Atherosclerotic Plaques

Pengbo Hou

Overview This repository contains de-identified raw and processed imaging mass cytometry (IMC) data supporting the study entitled “Spatial Single-Cell Proteomics Identifies Macrophage Niches Driving Human Carotid Plaque Instability.” The repository includes pixel-level raw IMC acquisition data, processed multichannel images, cell-segmentation masks, extracted …

Imaging Mass Cytometry Dataset of Human Carotid Atherosclerotic Plaques_Cohort_2

Pengbo Hou

Description This repository contains de-identified raw and processed imaging mass cytometry (IMC) data generated from 62 human carotid atherosclerotic plaque specimens obtained from 47 patients in Cohort 2. The dataset comprises 227 regions of interest (ROIs) and 543,113 segmented cells. Pixel-level raw …

Visium HD FFPE Human Carotid Plaque Dataset

Pengbo Hou

This repository contains Space Ranger–processed Visium HD spatial transcriptomic data generated from an FFPE section of a human carotid atherosclerotic plaque (Patient08, Cohort 1). A serial FFPE section from the same plaque was analyzed by imaging mass cytometry (IMC), enabling region-level comparison …

Visium HD FFPE Human Carotid Plaque Dataset

Pengbo Hou

This repository contains Space Ranger–processed Visium HD spatial transcriptomic data generated from an FFPE section of a human carotid atherosclerotic plaque (Patient08, Cohort 1). A serial FFPE section from the same plaque was analyzed by imaging mass cytometry (IMC), enabling region-level comparison …

Single-cell RNA and CITE-seq analysis of human CD4+ T cells reveals age-associated upregulation of IL-32 2259951

Lauren Fogel, Qingkang Lyu, Klaus Ley, Pengbo Hou et autres

Abstract Introduction Aging profoundly alters the human immune system, leading to increased vulnerability to infection, autoimmunity, and cardiovascular disease. Methods To define how aging reshapes CD4+ T-cell phenotypes and transcriptional programs, we performed single-cell RNA sequencing combined with CITE-seq (51 surface proteins) …

us, tw (code pays fourni par la source)

DEA projection and its decomposition approach based on expected efficiency targets

Zhanxin Ma, Pengbo Hou, Yuzhen Tian

cn (code pays fourni par la source)

Dexamethasone promotes neutrophil ROS-mediated tumor killing through the glucocorticoid receptor

Zhanhong Liu, Rongrong Sun, Yinghong Li, Ziqi Zhang et autres

cn, it (code pays fourni par la source)

IGF2 regulates proliferation, differentiation, and mitochondrial bioenergetics in human satellite cells

Ramouna Voshtani, Pengbo Hou, Zhanhong Liu, Lijuan Cao et autres

Insulin-like growth factors (IGFs) are key regulators of the stem cell niche, playing critical roles in the proliferation and differentiation of stem cells into various lineages, including skeletal muscle. While IGF2 is known to influence muscle development, its specific effects and mechanisms …

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Retraction Note: Exogenous supplement of N-acetylneuraminic acid improves macrophage reverse cholesterol transport in Apolipoprotein E-deficient mice

Pengbo Hou, Shumei Hu, Jin Wang, Zixun Yang et autres

cn (code pays fourni par la source)

Stage-resolved Spatial Multi-omics Reveals Myeloid Niches in Human Atherosclerotic Plaques

Pengbo Hou, Huan Cai, Zhanhong Liu, Jiankai Fang et autres

Abstract Background Atherosclerosis, a leading cause of heart attack and stroke, involves intricate immune cell dynamics within arterial plaques, yet their spatial organization and functional roles remain elusive. Methods We combined Visium HD spatial transcriptomics, imaging mass cytometry, and single-cell RNA-seq across …

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Species variations in muscle stem cell-mediated immunosuppression on T cells

Shisong Liu, Pengbo Hou, Weijia Zhang, Muqiu Zuo et autres

Muscle stem cells (MuSCs) are effective in treating inflammatory diseases driven by overactive innate immune responses, such as colitis and acute lung injury, due to their immunomodulatory properties. However, their potential in treating diseases driven by adaptive immune responses is still uncertain. …

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