Species variations in muscle stem cell-mediated immunosuppression on T cells
Rattachement africain : cn, it. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Muscle stem cells (MuSCs) are effective in treating inflammatory diseases driven by overactive innate immune responses, such as colitis and acute lung injury, due to their immunomodulatory properties. However, their potential in treating diseases driven by adaptive immune responses is still uncertain. When primed with inflammatory cytokines, MuSCs strongly suppressed T cell activation and proliferation in vitro in co-culture with activated splenocytes or peripheral blood mononuclear cells. Systemic administration of MuSCs from both mice and humans alleviated pathologies in mice with concanavalin A-induced acute liver injury, characterized by hyperactivated T lymphocytes. Importantly, MuSCs showed significant species-specific differences in their immunoregulatory functions. In mouse MuSCs (mMuSCs), deletion or inhibition of inducible nitric oxide synthase (iNOS) reduced their immunosuppressive activity, and absence of iNOS negated their therapeutic effects in liver injury. Conversely, in human MuSCs (hMuSCs), knockdown or inhibition of indoleamine 2,3-dioxygenase (IDO) eliminated their immunosuppressive effects, and loss of IDO function rendered hMuSCs ineffective in treating liver injury in mice. These results reveal significant species-specific differences in the mechanisms by which MuSCs mediate T cell immunosuppression. Mouse MuSCs rely on iNOS, while human MuSCs depend on IDO expression. This highlights the need to consider species-specific responses when evaluating MuSCs' therapeutic potential in immune-related disorders.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Species variations in muscle stem cell-mediated immunosuppression on T cells
- Date Crossref
- 08/10/2024
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Soochow University Laboratory Animal Center pays non établi dans la noticeUniversité ou école supérieure
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The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital) pays non établi dans la noticeÉtablissement de santé
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State Key Laboratory of Radiation Medicine and Protection pays non établi dans la noticeStructure de recherche
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Shandong University pays non établi dans la noticeUniversité ou école supérieure
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University of Rome Tor Vergata pays non établi dans la noticeUniversité ou école supérieure
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School of Basic Medical Sciences Key Laboratory of Experimental Teratology pays non établi dans la noticeUniversité ou école supérieure
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University of Rome "Tor Vergata" Department of Experimental Medicine and Biochemical Sciences pays non établi dans la noticeUniversité ou école supérieure
Laboratory Animal Center — Soochow University, The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital) et State Key Laboratory of Radiation Medicine and Protection, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.