Accès ouvert
2025
conference-abstract
OpenAlex
Lakshmi Sandhow, Huan Cai, Hong Wei Qian
Abstract Background: Signal-induced proliferation-associated gene 1 (Sipa1), a RAP1 GTPase-activating protein, is expressed in both hematopoietic cells and stromal cells. It negatively regulates G-protein signaling pathways involving in cell adhesion and proliferation. We have demonstrated that Sipa1loss induces bone marrow (BM) mesenchymal …
se
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Pengbo Hou, Huan Cai, Zhanhong Liu, Jiankai Fang et autres
Abstract Background Atherosclerosis, a leading cause of heart attack and stroke, involves intricate immune cell dynamics within arterial plaques, yet their spatial organization and functional roles remain elusive. Methods We combined Visium HD spatial transcriptomics, imaging mass cytometry, and single-cell RNA-seq across …
cn, tw, us, it
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Ingrid Lilienthal, Sijia Tao, Christer C. Nilsson, Elory Leonard et autres
Despite intensive treatment, patients with relapsed or refractory acute myeloid leukaemia (AML) have a dismal prognosis. A cornerstone therapy for relapsed/refractory AML is a combination of fludarabine (F-ara-A) and cytarabine (ara-C), so-called FLA. As the enzyme SAMHD1 mediates resistance to both ara-C …
se, us, ru
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Maritha Kumlin, Johanna S. Ungerstedt, Huan Cai, Elory Leonard et autres
Traumatic or degenerative joint pain is abundant in the population. Symptom relief by intra- and periarticular glucocorticoid administration is frequently used, however may have potentially devastating effects, changing the normal healing process of the joint. Mesenchymal stem cells (MSCs) are important for …
se
(code pays fourni par la source)
Accès ouvert
2023
conference-abstract
OpenAlex
Alma Månsson, Huan Cai, Juan Pablo Medina, Leif Stenke et autres
Although tyrosine kinase inhibitors (TKIs) have dramatically improved the treatment outcomes of chronic myeloid leukemia (CML), TKIs cannot eliminate CML-initiating stem cells (LSCs), leading to CML persistence and relapse post TKI-discontinuation. Thus, it is imperative to develop more effective therapeutic options to …
se
(code pays fourni par la source)
Accès ouvert
2023
conference-abstract
OpenAlex
Elory Leonard, Lakshmi Sandhow, Huan Cai, Hong Wei Qian
Leukemia cutis (LC) or leukemic cell infiltration in skin is one of the common extramedullary manifestations in acute myeloid leukemia (AML) and signifies a poorer prognosis. However, the pathogenesis and maintenance of LC have been understudied, limiting our understanding of its impact …
se
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Ting Wang, Yongqiang Dong, Zhiqiang Huang, Guoqing Zhang et autres
Lung cancer progression relies on angiogenesis, which is a response to hypoxia typically coordinated by hypoxia-inducible transcription factors (HIFs), but growing evidence indicates that transcriptional programs beyond HIFs control tumor angiogenesis. Here, we show that the redox-sensitive transcription factor BTB and CNC …
se, cn
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Lakshmi Sandhow, Huan Cai, Elory Leonard, Pingnan Xiao et autres
Leukemia cutis or leukemic cell infiltration in skin is one of the common extramedullary manifestations of acute myeloid leukemia (AML) and signifies a poorer prognosis. However, its pathogenesis and maintenance remain understudied. Here, we report massive AML cell infiltration in the skin …
se
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Monika B. Dolinska, Huan Cai, Alma Månsson, Jingyi Shen et autres
Although tyrosine kinase inhibitors (TKIs) are effective in treating chronic myeloid leukemia (CML), they often fail to eradicate the leukemia-initiating stem cells (LSCs), causing disease persistence and relapse. Evidence indicates that LSC persistence may be because of bone marrow (BM) niche protection; …
se, fi
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Zewei Tu, Xiaolin Wang, Huan Cai, Yilei Sheng et autres
Cyclin-dependent kinase inhibitor 2A (CDKN2A) encodes the cell senescence regulator protein p16. The expression of p16 raises in cell senescence and has a nuclear regulation in cell aging. Meanwhile, it's also reported to inhibit the aggression of several cancers. But its clinical …
cn
(code pays fourni par la source)
Accès ouvert
2022
preprint
OpenAlex
Yaser Heshmati, Gözde Türköz, Marios Dimitriou, Aditya Harisankar et autres
Abstract Acute myeloid leukemia (AML) is an aggressive blood malignancy characterized by clonal accumulation of immature myeloid progenitors in the bone marrow and peripheral blood. Transcription factors are the most frequently mutated and dysregulated genes in AML, and they have critical roles …
se
(code pays fourni par la source)
Accès ouvert
2022
preprint
OpenAlex
Lakshmi Sandhow, Huan Cai, Elory Leonard, Pingnan Xiao et autres
Abstract Leukemia cutis or leukemic cell infiltration in skin is one of the common extramedullary manifestations of acute myeloid leukemia (AML) and signifies a poorer prognosis. However, its pathogenesis and maintenance remain understudied. Here, we report massive AML cell infiltration in the …
se
(code pays fourni par la source)