Accès ouvert
2026
article
OpenAlex
Kyle J. Missen, J H Brown, Ross M. Mandeville, Harvey Wu et autres
OBJECTIVES: Nerve transfer is a promising intervention for restoring hand and upper limb function after cervical spinal cord injury (SCI), but the timeline of neurophysiological recovery in humans remains unclear. This study aimed to define recovery profiles after nerve transfers to restore …
ca, us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Rachel A Crompton, Denis C. Szondi, Christopher Doherty, Helen A. Thomason et autres
SUMMARY Wound infection is a major disruptor of wound healing. Keratinocytes, critical in repair and microbial responses, require the L-arginine hydrolysing enzyme arginase1, for effective healing. Wound pathogens such as Pseudomonas aeruginosa may also need L-arginine. We therefore investigated host-microbial interactions in …
gb, sg, fr
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Steven D. Mercer, Christopher Doherty, Gurdeep Singh, Thomas Willmott et autres
Periodontitis is a chronic gum disease characterised by inflammation and the loss of bone. We have explored the potential prophylactic effects of lysates from four Lactobacillus strains against the toxic effects of three periodontal pathogens (Porphyromonas gingivalis, Fusobacterium nucleatum, and Aggregatibacter actinomycetemcomitans). …
gb, th
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Reem Binsuwaidan, Osama Almuzaini, Steven D. Mercer, Christopher Doherty et autres
Silver compounds are used in wound dressings to reduce bioburden. Where infection is not rapidly resolved, bacteria may be exposed to sub-therapeutic concentrations of antimicrobials over prolonged periods of time. In this study, a panel of chronic wound bacteria, Pseudomonas aeruginosa (two …
sa, gb
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Kara M Buzza, Alain Pluen, Christopher Doherty, Tanaporn Cheesapcharoen et autres
Zinc salts are added to dentifrices to improve oral hygiene through the control of dental plaque. We describe a method for determining biofilm permeability and show a moderate inhibitory effect of zinc acetate on biofilm formation, and that this inhibitory effect is …
gb, us
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Christopher Doherty, Charlotte V. Byrne, Sajwa Baqader, Cécile El‐Chami et autres
Abstract Microbial growth within a wound often manifests as biofilms, which can prevent healing and is difficult to eradicate. Novel silver dressings claim to combat wound infection, but anti-biofilm efficacy and effects on healing independent of infection are often unclear. Using in …
gb, sa, pk
(code pays fourni par la source)