Neurophysiological Recovery Following Nerve Transfer Surgery to Restore Upper Limb Function after Cervical Spinal Cord Injury
Rattachement africain : ca, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
OBJECTIVES: Nerve transfer is a promising intervention for restoring hand and upper limb function after cervical spinal cord injury (SCI), but the timeline of neurophysiological recovery in humans remains unclear. This study aimed to define recovery profiles after nerve transfers to restore upper limb function. METHODS: Individuals with traumatic cervical SCI who received nerve transfer surgery in at least 1 limb were evaluated during routine clinical visits for up to 2 years post-transfer. The primary outcome was the time to detect reinnervation, defined as the appearance of voluntary motor unit potentials on needle electromyography. Representative muscles were assessed for 5 nerve transfer procedures: (1) supinator to posterior interosseous nerve; (2) brachialis to anterior interosseous nerve (AIN); (3) extensor carpi radialis longus to AIN; (4) extensor carpi radialis brevis to AIN; and (5) axillary to triceps. In a subset of participants who continued needle electromyography after reinnervation was detected, an ordinal grading system characterized motor unit potential maturity and the presence of pathological spontaneous activity over time. RESULTS: A total of 44 individuals with traumatic cervical SCI were enrolled. Mean times to detect reinnervation were 6.9 months (supinator-posterior interosseous nerve), 10.4 months (brachialis-AIN), 9.6 months (extensor carpi radialis longus-AIN), 9.6 months (extensor carpi radialis brevis-AIN), and 9.0 months (axillary-triceps). Over time, reinnervated muscles showed reduced pathological spontaneous activity and progression from nascent to mature motor unit potentials. INTERPRETATION: These findings establish benchmark timelines for first detection of neurophysiological reinnervation after nerve transfer in cervical SCI, providing a foundation for setting clinical expectations, planning rehabilitation, and designing future interventional studies. ANN NEUROL 2026;100:867-875.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Neurophysiological Recovery Following Nerve Transfer Surgery to Restore Upper Limb Function after Cervical Spinal Cord Injury
- Date Crossref
- 06/07/2026
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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GF Strong Rehabilitation Centre pays non établi dans la noticeÉtablissement de santé
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International Collaboration On Repair Discoveries pays non établi dans la noticeStructure de recherche
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Massachusetts General Hospital Department of Neurosurgery pays non établi dans la noticeÉtablissement de santé
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Beth Israel Deaconess Medical Center Department of Neurology pays non établi dans la noticeÉtablissement de santé
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Harvard University pays non établi dans la noticeUniversité ou école supérieure
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Vancouver Coastal Health pays non établi dans la noticeÉtablissement de santé
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Vancouver General Hospital pays non établi dans la noticeÉtablissement de santé
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St. John's Rehab Hospital pays non établi dans la noticeÉtablissement de santé
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Sunnybrook Hospital pays non établi dans la noticeÉtablissement de santé
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University of Toronto and Aesthetic Surgery pays non établi dans la noticeUniversité ou école supérieure
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Queen's University Department of Surgery pays non établi dans la noticeUniversité ou école supérieure
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Kingston Health Sciences Centre pays non établi dans la noticeÉtablissement de santé
GF Strong Rehabilitation Centre, International Collaboration On Repair Discoveries et Department of Neurosurgery — Massachusetts General Hospital, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.