Accès ouvert
2026
article
OpenAlex
Steven D. Mercer, Anni Elias, George Taylor, Geoff S. Briggs et autres
ABSTRACT Ultraviolet radiation (UVR) is an environmental stressor to the skin and its associated microbiota. Many commensal bacteria produce tryptophan-derived metabolites that modulate epidermal barrier function through aryl hydrocarbon receptor (AhR) signaling. However, the effects of UVR on these metabolic outputs and …
gb, ca, cn
(code pays fourni par la source)
Accès ouvert
2026
dataset
OpenAlex
Steven D. Mercer, C. O'Neill
Ultraviolet radiation (UVR) is an environmental stressor to the skin and its associated microbiota. Many commensal bacteria produce tryptophan-derived metabolites that modulate epidermal barrier function through aryl hydrocarbon receptor (AhR) signalling. However, the effects of UVR on these metabolic outputs and the …
gb
(code pays fourni par la source)
Accès ouvert
2026
dataset
OpenAlex
Steven D. Mercer, C. O'Neill
Ultraviolet radiation (UVR) is an environmental stressor to the skin and its associated microbiota. Many commensal bacteria produce tryptophan-derived metabolites that modulate epidermal barrier function through aryl hydrocarbon receptor (AhR) signalling. However, the effects of UVR on these metabolic outputs and the …
gb
(code pays fourni par la source)
2025
conference-paper
OpenAlex
Shreena Joshi Pradhan, H. Gong, Steven D. Mercer, Amin Molahassani et autres
Introduction: Structured learning events (SLEs) are a key component of the pharmacy curricula to develop consultation skills. While effective, these sessions are resource intensive. This study explored the use of virtual reality (VR) combined with generative artificial intelligence (GenAI) to replicate the …
gb
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Steven D. Mercer, Andrew J. McBain, Catherine O’Neill
Ultraviolet radiation (UVR) presents one of the greatest challenges to human skin, with numerous studies documenting its effects on skin physiology. Recently, growing recognition of the microbiome's crucial role in skin health has led to investigations on how UVR influences skin-microbiome interactions. …
gb
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Steven D. Mercer, Samantha Smith, Maria Christofi, Paul Martin et autres
Abstract Background/Aims Juvenile idiopathic arthritis (JIA) affects approximately 12,000 children in the UK, half of whom fail to improve on treatment. There is therefore a significant clinical need for new therapies in JIA. A CD25 (IL2RA) enhancer variant associated with JIA has …
gb
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Steven D. Mercer, Christopher Doherty, Gurdeep Singh, Thomas Willmott et autres
Periodontitis is a chronic gum disease characterised by inflammation and the loss of bone. We have explored the potential prophylactic effects of lysates from four Lactobacillus strains against the toxic effects of three periodontal pathogens (Porphyromonas gingivalis, Fusobacterium nucleatum, and Aggregatibacter actinomycetemcomitans). …
gb, th
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Thomas Willmott, Paul P. Kelly, Layali Jadaan, Danna R. Gifford et autres
The study was conducted to inform risk assessments concerning microbial exposure to quaternary ammonium biocides (QUATs) by investigating their effects on 10 microbial strains of hygiene relevance. Biocides were divided into three categories: simple aqueous solutions, biocide mixtures, and formulated biocides. Organisms …
gb
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Reem Binsuwaidan, Osama Almuzaini, Steven D. Mercer, Christopher Doherty et autres
Silver compounds are used in wound dressings to reduce bioburden. Where infection is not rapidly resolved, bacteria may be exposed to sub-therapeutic concentrations of antimicrobials over prolonged periods of time. In this study, a panel of chronic wound bacteria, Pseudomonas aeruginosa (two …
sa, gb
(code pays fourni par la source)