Lis Noelia Velásquez

Indirect inhibition of the NLRP3-interleukin-1β axis contributes to the efficacy of JAK1 inhibitors in experimental colitis and human ulcerative colitis

Beibei Liu, Marianne R. Spalinger, Annalisa Invernizzi, Eike Gerdes et autres

Tofacitinib, a pan-Janus kinase inhibitor, and the Janus kinase 1-preferential inhibitors Upadacitinib and Filgotinib are approved for the treatment of ulcerative colitis, yet their molecular mechanisms of action remain incompletely understood. Here, using dextran sulfate sodium-induced and T cell transfer colitis models …

de, ch (code pays fourni par la source)

Indirect inhibition of the NLRP3-interleukin-1β axis contributes to the efficacy of JAK1 inhibitors in experimental colitis and human ulcerative colitis

Beibei Liu, Marianne R Spalinger, Annalisa Invernizzi, Eike Gerdes et autres

Tofacitinib, a pan-Janus kinase inhibitor, and the Janus kinase 1-preferential inhibitors Upadacitinib and Filgotinib are approved for the treatment of ulcerative colitis, yet their molecular mechanisms of action remain incompletely understood. Here, using dextran sulfate sodium-induced and T cell transfer colitis models …

Crosstalk between the microbiota and intestinal dendritic cells in IBD

Philine Letz, Samuel J. Huber, Lis Noelia Velásquez

Conventional dendritic cells (cDCs) play a pivotal role in orchestrating the delicate balance between immunity and tolerance within the gastrointestinal tract by interacting with other cell types, particularly T cells. Meanwhile, the microbiota is critical for the induction and modulation of the …

de (code pays fourni par la source)

Disparity Between Functional and Structural Recovery of Placental Mitochondria After Exposure to Hypoxia

Jonathan R. Sierla, Laia Pagerols Raluy, Magdalena Trochimiuk, Julian Trah et autres

Intrauterine growth restriction (IUGR) affects 5–10% of pregnancies with placental hypoxia, playing a key role as a common pathophysiological pathway of different etiologies. Despite the high metabolic rate of the placenta and its “gatekeeper” role in protecting the fetus from hypoxia, the …

de (code pays fourni par la source)

All Three AKT Isoforms Can Upregulate Oxygen Metabolism and Lactate Production in Human Hepatocellular Carcinoma Cell Lines

Lingyu Tian, Daniel J. Smit, N. V. Popova, Stefan Horn et autres

Hepatocellular carcinoma (HCC), the main pathological type of liver cancer, is related to risk factors such as viral hepatitis, alcohol intake, and non-alcoholic fatty liver disease (NAFLD). The constitutive activation of the PI3K/AKT signaling pathway is common in HCC and has essential …

de, cn (code pays fourni par la source)

Impact of hypoxia on the mitochondrial function of JEG-3 choriocarcinoma cells

Jonathan R. Sierla, Laia Pagerols-Raluy, Magdalena Trochimiuk, Julian Trah et autres

Introduction Intrauterine growth retardation (IUGR) affects 5-10% of all pregnancies. Leading causes for this pathology can be maternal, placental, and fetal factors.[ 1 ] Especially maternal diseases which are concomitant with chronic hypoxia are relevant. Pregnancies in high altitudes are also associated …

de (code pays fourni par la source)

Tr1 Cells Emerge and Suppress Effector Th17 Cells in Glomerulonephritis

Shiwa Soukou-Wargalla, Christoph Kilian, Lis Noelia Velásquez, Andrés Machicote et autres

T regulatory type 1 (Tr1) cells, which are defined by their regulatory function, lack of Foxp3, and high expression of IL-10, CD49b, and LAG-3, are known to be able to suppress Th1 and Th17 in the intestine. Th1 and Th17 cells are …

de (code pays fourni par la source)

Inhibition of Mitochondrial Translation Ameliorates Imiquimod-Induced Psoriasis-Like Skin Inflammation by Targeting Vγ4+ γδ T Cells

Ayesha Dhillon-LaBrooy, Kathrin Luise Braband, Eshraq Tantawy, Francesca Rampoldi et autres

de, br (code pays fourni par la source)

Targeting ACC1 in T cells ameliorates psoriatic skin inflammation

Yu-San Kao, Panagiota Mamareli, Ayesha Dhillon-LaBrooy, Philipp Stüve et autres

Abstract Psoriasis is a chronic inflammatory skin disease driven by the IL-23/IL-17 axis. It results from excessive activation of effector T cells, including T helper (Th) and cytotoxic T (Tc) cells, and is associated with dysfunctional regulatory T cells (Tregs). Acetyl-CoA carboxylase …

de (code pays fourni par la source)

Emergence and suppressive function of Tr1 cells in glomerulonephritis

Shiwa Soukou-Wargalla, Christoph Kilian, Lis Noelia Velásquez, Andrés Machicote et autres

Summary T regulatory type 1 (Tr1) cells, which are defined by their regulatory function, lack of Foxp3, high expression of IL-10, CD49b, and LAG3, are known to be able to suppress Th1 and Th17 in the intestine. Th1 and Th17 cells are …

de (code pays fourni par la source)

Microbial RNA, the New PAMP of Many Faces

M. Ayelén Milillo, Lis Noelia Velásquez, Paula Barrionuevo

Traditionally, pathogen-associated molecular patterns (PAMPs) were described as structural molecular motifs shared by different classes of microorganisms. However, it was later discovered that the innate immune system is also capable of distinguishing metabolically active microbes through the detection of a special class …

ar, de (code pays fourni par la source)

Dendritic cell metabolism: moving beyond in vitro-culture-generated paradigms

Lucía Minarrieta, Lis Noelia Velásquez, Tim D. Sparwasser, Luciana Berod

ca, de (code pays fourni par la source)