M. Ayelén Milillo

Bacterial RNA downregulates MHC-I in tumor cell lines, promoting NK response and delaying tumor growth

Agustina Serafino, Mónica Vermeulen, Yasmín Ayelén Bertinat, Federico Birnberg-Weiss et autres

Immunotherapy has introduced a new era in cancer treatment. The clinical goal of cancer immunotherapy is to prime the host immune system to provide passive or active immunity against malignant tumors. We have previously demonstrated that Brucella abortus (Ba) RNA downregulates IFN-γ-induced …

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Bacterial RNA downregulates MHC-I in tumor cell lines, promoting NK response and delaying tumor growth

Agustina Serafino, Mónica Vermeulen, Yasmín Ayelén Bertinat, Federico Birnberg-Weiss et autres

Files corresond to raw data collected for the manuscript.

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News and COVID-19 Vaccines in Argentina: A Topic Modeling Analysis

Erick Daniel Cruz Mendoza, Luciano Levin, M. Ayelén Milillo

El análisis de los medios de comunicación se presenta como un elemento central para comprender el desarrollo de la pandemia de Covid-19, ya que ofrece información clave sobre su dinámica y gestión. En este contexto, la agenda mediática durante los años de …

Revisión de la producción académica abierta sobre comunicación y pandemia en Argentina y México

Bárbara Burton, M. Ayelén Milillo, Mariana Langenheim, Cecilia Rosen

En este trabajo realizamos un relevamiento bibliográfico de la producción académica de acceso abierto sobre comunicación y pandemia por COVID-19 (de marzo de 2020 a octubre de 2023) en Argentina y México. El corpus (n=101) se conformó a partir de búsquedas en …

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Noticias y vacunas Covid-19 en Argentina: un análisis de modelación temática

Erick Daniel Cruz Mendoza, Luciano Levin, M. Ayelén Milillo

The analysis of media coverage presents itself as a central element for understanding the development of the Covid-19 pandemic, as it provides key insights into its dynamics and management. In this context, media agendas have been shaped by emerging knowledge about the …

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Activismos ante las medidas sanitarias frente a la COVID-19 en Argentina

Bárbara Burton, M. Ayelén Milillo, Sandra Murriello

La pandemia por el SARS-CoV-2 se dio en un contexto de modificaciones de las dinámicas informativas y de comunicación en el que las noticias falsas y la desinformación y a se presentaban como un desafío complejo. En este contexto de caos informativo, …

Beyond its preferential niche: Brucella abortus RNA down-modulates the IFN-γ-induced MHC-I expression in epithelial and endothelial cells

Agustina Serafino, Yasmín A. Bertinat, Jorgelina Bueno, José R. Pittaluga et autres

Brucella abortus (Ba) is a pathogen that survives inside macrophages. Despite being its preferential niche, Ba infects other cells, as shown by the multiple signs and symptoms humans present. This pathogen can evade our immune system. Ba displays a mechanism of down-modulating …

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Brucella abortus RNA does not polarize macrophages to a particular profile but interferes with M1 polarization

Agustina Serafino, José Luis Marín Franco, Mariano Maio, Aldana Trotta et autres

Monocytes and macrophages play a central role in chronic brucellosis. Brucella abortus (Ba) is an intracellular pathogen that survives inside these cells. On the other hand, macrophages could be differentiated into classical (M1), alternative (M2) or other less-identified profiles. We have previously …

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Microbial RNA, the New PAMP of Many Faces

M. Ayelén Milillo, Lis Noelia Velásquez, Paula Barrionuevo

Traditionally, pathogen-associated molecular patterns (PAMPs) were described as structural molecular motifs shared by different classes of microorganisms. However, it was later discovered that the innate immune system is also capable of distinguishing metabolically active microbes through the detection of a special class …

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Fatty acid oxidation of alternatively activated macrophages prevents foam cell formation, but Mycobacterium tuberculosis counteracts this process via HIF-1α activation

Melanie Genoula, José Luis Marín Franco, Mariano Maio, Belén Dolotowicz et autres

The ability of Mycobacterium tuberculosis (Mtb) to persist inside host cells relies on metabolic adaptation, like the accumulation of lipid bodies (LBs) in the so-called foamy macrophages (FM), which are favorable to Mtb. The activation state of macrophages is tightly associated to …

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Brucella abortus–infected platelets modulate the activation of neutrophils

Aldana Trotta, M. Ayelén Milillo, Agustina Serafino, Luis A Castillo et autres

Brucellosis is a contagious disease caused by bacteria of the genus Brucella. Platelets (PLTs) have been widely involved in the modulation of the immune response. We have previously reported the modulation of Brucella abortus-mediated infection of monocytes. As a result, PLTs cooperate …

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Mycobacterium tuberculosis Modulates the Metabolism of Alternatively Activated Macrophages to Promote Foam Cell Formation and Intracellular Survival

Melanie Genoula, José Luis Marín Franco, Mariano Maio, Belén Dolotowicz et autres

ABSTRACT The ability of Mycobacterium tuberculosis (Mtb) to persist inside host cells relies on metabolic adaptation, like the accumulation of lipid bodies (LBs) in the so-called foamy macrophages (FM). Indeed, FM are favorable to Mtb. The activation state of macrophages is tightly …

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