А. Е. Солопова

The role of neoadjuvant chemotherapy in the treatment of locally advanced cervical cancer, or 40 years of walking in the evidence desert

R. K. Tandelov, A. A. Petrozhitskaya, А. Е. Солопова, K. Yu. Morkhov

The study of the role of neoadjuvant chemotherapy (NACT) began with pioneering works in the early 1980s and has been ongoing for over 40 years. During this period, numerous randomized clinical trials have been conducted, many scrupulous meta-analyses have been performed, and …

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Background and precancerous diseases of the vulva and vagina: modern concepts, diagnostics, treatment and rehabilitation

А. Е. Солопова, A. V. Vorobеv, J. Kh. Khizroeva, А. Е. Ivanov et autres

The article is devoted to modern aspects of classification, epidemiology, pathogenesis, diagnostics, treatment and rehabilitation of background and precancerous diseases of the vulva and vagina. Particular attention is paid to stratification of intraepithelial neoplasia by HPV status, the role of immunohistochemical markers …

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Cerebral vein thrombosis: management tactics with a focus on pregnancy, the use of hormone therapy and assisted reproductive technologies

S.V. Akinshina, В. О. Бицадзе, J. Kh. Khizroeva, M. V. Tretyakova et autres

Cerebral vein thrombosis is a rare, life-threatening condition that has now become more commonly diagnosed due to advancements in imaging techniques. Our purpose is to improve understanding of pathogenesis, diagnosis and pregnancy and IVF management in patients with a history of cerebral …

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MRI characteristics of deep infiltrating endometriosis: correlation with clinical symptoms

А. Е. Солопова, Patimat M. Alieva, M R Dumanovskaya, A. A. Smetnik et autres

Objective. To study the correlation between structural characteristics, localization of deep infiltrating endometriosis (DIE) according to magnetic resonance imaging (MRI) and the severity of clinical symptoms, as well as to evaluate the diagnostic accuracy of MRI using the ENZIAN classification and compare …

Outpatient diagnosis and drug therapy of endometriosis: A review

А. Е. Солопова, Patimat M. Alieva, M R Dumanovskaya, Guzal I. Tabeeva et autres

Endometriosis affects about 10% of women of reproductive age and can negatively impact their quality of life (QoL). Due to the heterogeneity of symptoms or even their absence, early diagnosis is difficult. Therefore, it is necessary to comprehensively assess the patient's complaints, …

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Assessment of the rehabilitation programs effectiveness in patients with painful external genital endometriosis

E. Begovich, B. Baigalmaa, А. Е. Солопова, В. О. Бицадзе et autres

In patients with a painful form of external genital endometriosis (EGE), the prevailing symptom is chronic pelvic pain, which significantly reduces the quality of life (QoL). It causes disorders of the physical, psycho-emotional and sexual health of women of reproductive age, leading …

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The role of the microenvironment in tumor growth and spreading

В. О. Бицадзе, Е. V. Slukhanchuk, А. Г. Солопова, J. Kh. Khizroeva et autres

Introduction. The tumor microenvironment (TME) consisting of non-tumor cells and other components plays a crucial role in cancer development by promoting uncontrolled tumor growth. Aim: to detail all the components in TME and their contribution to carcinogenesis by analyzing available publications. Results. …

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Hereditary and acquired thrombophilia in a patient with endometrial adenocarcinoma

Е. V. Slukhanchuk, В. О. Бицадзе, А. Г. Солопова, J. Kh. Khizroeva et autres

This article presents a clinical case of a 46-year-old patient with aggravated obstetric and gynecological history, personal and family thrombotic history, who underwent surgery for endometrial adenocarcinoma complicated by the development of pulmonary embolism. The examination revealed hereditary and acquired forms of …

Potential of MRI-based radiomics in non-invasive pre-operative assessment of lymphovascular invasion in cervical cancer

А. Е. Солопова, Bendzhenova B.B. Bendzhenova, G N Khabas, С. В. Хохлова

Objective. To develop and validate a magnetic resonance imaging (MRI)-based prognostic model for pre-operative assessment of lymphovascular invasion (LVI) in cervical cancer (CC). Patients and methods. Clinical data from 109 patients aged 23–82 years with stage IA2-IIA2 CC were retrospectively analyzed. All …

Imaging of cervical cancer. Consensus of experts

Н. А. Рубцова, Т. П. Березовская, V.G. Bychenko, А. Е. Солопова et autres

The article offers the latest view on possibilities of diagnostic algorithm to identify cervical cancer (CC), one of the most incidental tumor of the woman’s reproductive system. The algorithm is described as a consensus of leading expert in imaging diagnostics, as well …

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Magnetic resonance imaging in cervical cancer: current opportunities of radiomics analysis and prospects for its further developmen

А. Е. Солопова, Yu. V. Nosova, Bendzhenova B.B. Bendzhenova

Introduction. Due to the dynamic development of modern imaging technologies in recent years, much attention has been paid to radiomics particularly texture analysis. The complexity of clinically evaluated tumor procession in cervical cancer (CC) accounts for a need to expand knowledge on …

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Non-gestational choriocarcinoma of ovary: Clinico-morphological features and diagnostic value of DNA polymorphism study

Alina Magnaeva, A.V. Asaturova, Anna Tregubova, I.A. Matsneva et autres

It is generally accepted that choriocarcinoma is a trophoblastic tumor of gestational origin during the reproductive period, but this neoplasm can rarely occur after menopause or be non-gestational making diagnosis a real challenge. In addition to this, somatic neoplasms can also undergo …

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