Sofieke J. D. Temmink

Risk of lymph node metastasis in pT2 rectal cancer: a nationwide retrospective analysis

Sander C Albers, Ritch Geitenbeek, Eline G M van Geffen, Tania C. Sluckin et autres

International guidelines recommend completion total mesorectal excision (TME) after local excision of pT2 rectal cancer with clear vertical and horizontal margins, regardless of histological risk factors1,2. This recommendation is largely based on the reported 18–26% risk of lymph node metastasis (LNM) in …

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Risks of Organ Preservation in Rectal Cancer: Data From Two International Registries on Rectal Cancer

Laura Melina Fernandez, Guilherme Pagin São Julião, Carlos Cerdán Santacruz, Andrew G. Renehan et autres

PURPOSE Organ preservation has become an attractive alternative to surgery (total mesorectal excision [TME]) among patients with rectal cancer after neoadjuvant therapy who achieve a clinical complete response (cCR). Nearly 30% of these patients will develop local regrowth (LR). Although salvage resection …

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Outcomes of watch and wait after short-course radiotherapy in an international multicentre watch-and-wait cohort

Barbara M. Geubels, Aart-Jan van den Esschert, Sofieke J. D. Temmink, Per Johan Nilsson et autres

Curative rectal cancer treatment has shifted toward organ preservation since the first report on watch and wait (W&W) as an alternative to total mesorectal excision (TME)1. For patients with locally advanced rectal cancer and a cCR after neoadjuvant therapy, presumed benefits of …

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Surgical Outcomes after Radiotherapy in Rectal Cancer

Sofieke J. D. Temmink, Koen C.M.J. Peeters, Per Johan Nilsson, Anna Martling et autres

Over the past decade, the treatment of rectal cancer has changed considerably. The implementation of TME surgery has, in addition to decreasing the number of local recurrences, improved surgical morbidity and mortality. At the same time, the optimisation of radiotherapy in the …

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Oncological outcomes after a pathological complete response following total neoadjuvant therapy or chemoradiotherapy for high-risk locally advanced rectal cancer in the RAPIDO trial

W.H. Zwart, Sofieke J. D. Temmink, Geke A.P. Hospers, Corrie A.M. Marijnen et autres

Background A pathological complete response (pCR) following chemoradiation (CRT) or short-course radiotherapy (scRT) leads to a favourable prognosis in patients with rectal cancer. Total neo-adjuvant therapy (TNT) doubles the pCR rate, but it is unknown whether oncological outcomes remain favourable and whether …

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Prognostic significance of MRI-detected extramural venous invasion according to grade and response to neo-adjuvant treatment in locally advanced rectal cancer A national cohort study after radiologic training and reassessment

Eline G M van Geffen, Joost Nederend, Tania C. Sluckin, Sanne-Marije J.A. Hazen et autres

BACKGROUND: Detection of grade 3-4 extra mural venous invasion (mrEMVI) on magnetic resonance imaging (MRI) is associated with an increased distant metastases (DM)-rate. This study aimed to determine the impact of different grades of mrEMVI and their disappearance after neoadjuvant therapy. METHODS: …

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Predictors of- and oncological outcomes after a pathological complete response following total neoadjuvant treatment or chemoradiotherapy for locally advanced rectal cancer in the RAPIDO trial

Sofieke J. D. Temmink, W.H. Zwart, Geke A.P. Hospers, Corrie A.M. Marijnen et autres

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Oncological Outcomes after a Pathological Complete Response Following Total Neoadjuvant Therapy or Chemoradiotherapy for High-Risk Locally Advanced Rectal Cancer in the RAPIDO Trial

W.H. Zwart, Sofieke J. D. Temmink, Geke A.P. Hospers, Corrie A.M. Marijnen et autres

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Abandonment of Routine Radiotherapy for Nonlocally Advanced Rectal Cancer and Oncological Outcomes

Sanne-Marije J.A. Hazen, Tania C. Sluckin, Martijn Intven, Geerard L. Beets et autres

Importance: Neoadjuvant short-course radiotherapy was routinely applied for nonlocally advanced rectal cancer (cT1-3N0-1M0 with >1 mm distance to the mesorectal fascia) in the Netherlands following the Dutch total mesorectal excision trial. This policy has shifted toward selective application after guideline revision in …

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Complete response rates in rectal cancer: Temporal changes over a decade in a population-based nationwide cohort

Sofieke J. D. Temmink, Anna Martling, Eva Angenete, Per Johan Nilsson

INTRODUCTION: In the past decade many changes in neoadjuvant treatment for patients with rectal cancer have taken place and are expected to impact complete response rates. The aim of this study was to investigate the impact on pathological, and overall, complete response …

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ASO Visual Abstract: Evaluation of National Surgical Practice for Lateral Lymph Nodes in Rectal Cancer in an Untrained Setting

Tania C. Sluckin, Sanne-Marije J.A. Hazen, Karin Horsthuis, Regina G. H. Beets‐Tan et autres

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Author response to: Comment on: Outcomes following watch and wait of a clinical complete response in rectal cancer after neoadjuvant treatment: comparison of patients with and without complete response at first reassessment in the International Watch & Wait Database (IWWD)

Sofieke J. D. Temmink, Koen C.M.J. Peeters, Andrew G. Renehan, Oriol Parés et autres

Dear Editor We thank S. Jones and co-authors for their interest in our article ‘Watch and wait after neoadjuvant treatment in rectal cancer: comparison of outcomes in patients with and without a complete response at first reassessment in the International Watch & …

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