Natasha Vorontsova

Using smartphone-based assessment of social experience to predict relapse in first-episode psychosis

Ryan Hammoud, Anna Georgiades, Maria Chiara Del Piccolo, Shangqing Liu et autres

Social-affective changes are early indicators of psychosis relapse, yet their dynamic and subjective nature makes them difficult to capture between routine clinical assessments. Smartphone-based ecological assessments offer a method for capturing real-time social experiences in daily life. To address this gap, we …

gb, cn, sa (code pays fourni par la source)

Associations between corticolimbic glutamatergic metabolites and functional connectivity in people at clinical high-risk for psychosis

Abigail Gee, Nicholas R Livingston, Amanda Kiemes, Samuel R. Knight et autres

Abstract Recent evidence suggests that psychosis involves glutamatergic dysfunction and altered activity/connectivity within corticolimbic circuitry. While altered relationships between corticolimbic glutamatergic metabolite levels and resting-state functional connectivity (FC) have been described in schizophrenia and first-episode psychosis (FEP), whether these disruptions are also …

gb, it, us (code pays fourni par la source)

Corticolimbic network perturbations in clinical high-risk and first-episode psychosis: an arterial spin labelling and [11C]Ro15-4513 positron emission tomography study

Samuel Knight, Julia J. Schubert, Paulina B. Lukow, Amanda Kiemes et autres

Background Hippocampal regional cerebral blood flow (rCBF) alterations in early psychosis may result from GABAergic inhibitory dysfunction within corticolimbic circuits. Traditional analyses used for rCBF and positron emission tomography (PET) are regional and not typically analysed within networks of dysfunction. Here, we …

gb, it, us (code pays fourni par la source)

GABAA receptor availability in clinical high-risk and first-episode psychosis: a [11C]Ro15-4513 positron emission tomography study

Paulina B. Lukow, Julia J. Schubert, Samuel Knight, Amanda Kiemes et autres

Abstract Disrupted gamma-aminobutyric acid (GABA) neurotransmission may contribute to the pathophysiology of schizophrenia. Reductions in hippocampal GABAergic neurons have been found in schizophrenia, and increased hippocampal perfusion has been described in schizophrenia and in people at clinical high-risk for psychosis (CHRp). We …

gb, it, de, us (code pays fourni par la source)

GABA A receptor availability in clinical high-risk and first-episode psychosis: a [ 11 C]Ro15-4513 positron emission tomography study

Paulina B. Lukow, Julia J. Schubert, Samuel Knight, Amanda Kiemes et autres

Abstract Disrupted gamma-aminobutyric acid (GABA) neurotransmission may contribute to the pathophysiology of schizophrenia. Reductions in hippocampal GABAergic neurons have been found in schizophrenia, and increased hippocampal perfusion has been described in schizophrenia and in people at clinical high-risk for psychosis (CHRp). We …

gb, it, us (code pays fourni par la source)

Modes, psychosis and bipolarity

John Edwin Rhodes, Natasha Vorontsova

This book explores how Schema Therapy and its underpinning theory, including the concept of modes, may advance our understanding of psychosis and bipolarity, with the potential to improve therapies. Clinicians and researchers alike have noted histories of early trauma, extreme negative appraisals …

Psychosis and Schema Therapy

John Edwin Rhodes, Natasha Vorontsova

This chapter will explore how Schema Therapy can be applied in working with clients experiencing psychosis, in particular those suffering from delusions and delusion related experiences. We propose that modes that express states such as self-attack or fear might amplify feelings of …

Developing the concept of modes in psychosis and bipolarity

John Edwin Rhodes, Natasha Vorontsova

The chapter argues that modes may contribute to the conceptualisation of psychosis and bipolarity and to therapy practice in four ways: first, modes can themselves influence distress; second, there is evidence in our case illustrations suggesting interactions between modes and symptoms; third, …

Exploring modes in bipolarity

John Edwin Rhodes, Natasha Vorontsova

By contrast with the participants with psychosis, the group with bipolar diagnoses reported a significant dominance of demanding modes and linked the activation of these with progression into manic mood phases. Angry mode activation was also connected with, and intensified during, manic …

Bipolarity and Schema Therapy

John Edwin Rhodes, Natasha Vorontsova

This chapter argues that individuals diagnosed with bipolarity suffer not only its specific symptoms but a wide range of emotional, interpersonal difficulties and other difficulties; furthermore, in clinical practice quite often the typical presentation is of someone who wavers between levels of …

Exploring modes in psychosis

John Edwin Rhodes, Natasha Vorontsova

We present here findings regarding the mode experiences of our group with psychotic diagnoses, illustrating their subjective descriptions and highlighting patterns. The modes of punitiveness, vulnerability and extreme anger loomed large in the accounts of our participants, and all three of these …

Schema Therapy Adapted for Psychosis and Bipolarity

John Edwin Rhodes, Natasha Vorontsova