Jiaxi Cheng

Puntuación SYNTAX para la evaluación de la carga y complejidad de la enfermedad arterial coronaria: pasado, presente y futuro

Zixiang Ye, Jiaxi Cheng, Joost Daemen, Roberto Diletti et autres

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NIR‐II Fluorescence Surgical Navigation for Gastric Cancer: Systematic Preclinical Validation Toward Clinical Application

X D Liu, Zhe Feng, Yunxue Xu, Jiaxi Cheng et autres

ABSTRACT The precise intraoperative delineation of gastric tumors and their micrometastases remains a major challenge in surgical oncology. To address this, we developed a novel NIR‐II fluorescent probe named SPN01 targeting integrin αvβ3, a receptor upregulated in gastric cancer and associated tumor …

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SYNTAX score for assessing coronary artery disease burden and complexity: past, present, and future

Zixiang Ye, Jiaxi Cheng, Joost Daemen, Roberto Diletti et autres

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The Association Between Fibrosis‐4 Index and All‐Cause and Cardiac Mortality in Patients With Coronary Heart Disease Combined With Diabetes or Prediabetes: Findings From Two Large‐Scale Prospective Cohort Studies

Chenxi Song, Zhihao Zheng, Xiaohui Bian, Zheng Qiao et autres

ABSTRACT Determining the link between fibrosis‐4 index (FIB‐4) score, which serves as a noninvasive metric for identifying liver cirrhosis, and mortality risks from all causes and cardiac causes in individuals with diabetes or prediabetes and confirmed cardiovascular disease remains ambiguous. This study …

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Comprehensive Immune-Phenotyping of Peripheral Lymphocytes in Coronary Artery Disease Reveals Potential Roles of Effector Memory and PD-1⁺ CD4⁺ T Cells

Xin Huang, Jiaxi Cheng, Leidan Zhang, Lei Jia et autres

Chronic inflammation plays a key role in the pathogenesis of coronary artery disease (CAD), yet the peripheral immune profile in CAD remains insufficiently characterized. This study aimed to assess circulating lymphocyte subsets in CAD patients and their potential clinical relevance. Peripheral blood …

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Aspirin-free strategy after short-term dual antiplatelet therapy in patients with complex percutaneous coronary intervention: A systematic review and network meta-analysis

Hao-Yu Wang, Su Yuan, Xin Yi, Guofeng Gao et autres

Objectives: The transition from short dual antiplatelet therapy (DAPT) to P2Y 12 inhibitor monotherapy has recently gained popularity as a strategy to reduce aspirin-related bleeding while preserving the antithrombotic benefit of DAPT. However, the safety and efficacy of P2Y 12 inhibitor monotherapy …

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Risk of Cardiovascular Disease Mortality in Patients With Diagnosed Cancer and Associated Genetic and Proteomic Mechanisms: A UK Biobank‐Based Cohort Study

Yuan Du, Sen Han, Jiaxi Cheng, Zhangyu Lin et autres

BACKGROUND: Previous studies have identified a link between cancer and cardiovascular disease; however, the underlying genetic and proteomic mechanisms remain unclear. Therefore, this study aimed to investigate the association between cancer diagnosis and cardiovascular mortality and to explore the potential mechanisms involved. …

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From Single-Cell and Bulk Transcriptomic Integration to Functional Verification: Triaptosis-Associated lncRNA Signature Predicts Survival and Guides Therapy in Hepatocellular Carcinoma

Xiaolong Liu, Ziyun Zhuang, Jiaxi Cheng, Duguang Li et autres

Background: Hepatocellular carcinoma (HCC) continues to be a major cause of cancer associated deaths worldwide, highlighting the need for new prognostic biomarkers and treatment strategies. Triaptosis, a recently characterized mode of regulated cell death, has shown potential as a therapeutic target in …

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pREdicting Long‐Term Major advErse carDiac and Cerebrovascular Events After Percutaneous coronarY Intervention: The REMEDY Score

Jiaxi Cheng, Chenxi Song, Haoyu Wang, Zhangyu Lin et autres

BACKGROUND: A clinically applicable tool incorporating comprehensive risk factors to evaluate long-term hard endpoints post-percutaneous coronary intervention (PCI) is currently lacking. AIMS: This study aims to develop a risk score from a large contemporary cohort to assess and stratify long-term risk of …

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TCT-965 Can Machine Learning Aid the Evaluation of the Risks of Bleeding vs Thrombotic Events in Patients at High Bleeding Risk After PCI?

Haoyu Wang, Jiaxi Cheng, Kefei Dou

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TGFBR3 dependent mechanism of TGFB2 in smooth muscle cell differentiation and implications for TGFB2-related aortic aneurysm.

Ying Tang, Jiaxi Cheng, Ping Qiu, Jingxin Li et autres

INTRODUCTION: Pathogenic variants in canonical transforming growth factor β (TGFβ) signaling genes predispose patients to thoracic aortic aneurysm and dissection (TAAD), predominantly in aortic root. Although TAAD pathogenesis associated with TGFβ receptor defects is well characterized, distinct and redundant mechanisms of TGFβ …

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Optimizing Long-term Cardiovascular Risk Stratification: Integrating Biomarkers into the Very High-Risk ASCVD Definition in Asian Patients

Jiaxi Cheng, Haoyu Wang, Chenxi Song, Xiaohui Bian et autres

The 2018 American Heart Association/American College of Cardiology (AHA/ACC) cholesterol guideline defines very high-risk (VHR) atherosclerotic cardiovascular disease (ASCVD) patients to guide intensive lipid-lowering therapy. This study sought to evaluate VHR's effectiveness in assessing cardiovascular (CV) risk in an Asian population and …

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