Zhe Feng

NIR‐II Fluorescence Surgical Navigation for Gastric Cancer: Systematic Preclinical Validation Toward Clinical Application

X D Liu, Zhe Feng, Yunxue Xu, Jiaxi Cheng et autres

ABSTRACT The precise intraoperative delineation of gastric tumors and their micrometastases remains a major challenge in surgical oncology. To address this, we developed a novel NIR‐II fluorescent probe named SPN01 targeting integrin αvβ3, a receptor upregulated in gastric cancer and associated tumor …

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Multiplexed optoacoustic tracking and magnetic actuation of labeled blood cells in living mice

Lin Tang, Quanyu Zhou, Hanna Preuss, Xuyang Chang et autres

Visualization of cellular dynamics in microvascular networks is essential for deciphering physiology and disease. Existing imaging platforms commonly lack the spatiotemporal resolution and sensitivity for single-cell tracking in vivo, particularly beyond the penetration depth of optical microscopy. While recent fluorescence and optoacoustic …

ch, de, cn (code pays fourni par la source)

NIR-II fluorescence projection technology for augmented-reality surgical navigation

Yuhuang Zhang, X Liu, Z. Liu, Changli Liu et autres

ABSTRACT NIR-II fluorescence imaging provides superior tissue penetration and clarity, yet its clinical use in surgical navigation is hindered by a critical workflow issue. Surgeons must divert their attention between the operative field and external monitors, increasing cognitive load and disrupting procedures. …

cn (code pays fourni par la source)

Covalent Bond Locking in Semiconducting Oligomers Boosts Ultrabright NIR‐II Luminescence for Deep Brain Theranostics

Xiliang Li, H. Y. Gan, Chi Zhang, Yijian Gao et autres

ABSTRACT Near‐infrared (NIR)‐II fluorescence imaging at 1000–1700 nm is widely used for deep‐tissue visualisation and disease theranostics in the brain, with NIR‐II theranostics greatly improving imaging resolution, imaging depth, and therapeutic efficacy. However, the extreme lack of molecular design in NIR‐II fluorophores …

cn (code pays fourni par la source)

Covalent Bond Locking in Semiconducting Oligomers Boosts Ultrabright NIR‐II Luminescence for Deep Brain Theranostics

Xiliang Li, H. Y. Gan, Chi Zhang, Yijian Gao et autres

Near-infrared (NIR)-II fluorescence imaging at 1000-1700 nm is widely used for deep-tissue visualisation and disease theranostics in the brain, with NIR-II theranostics greatly improving imaging resolution, imaging depth, and therapeutic efficacy. However, the extreme lack of molecular design in NIR-II fluorophores has …

cn (code pays fourni par la source)

Assessment of Cultivable Soil Health in China: A National-Scale Framework and Practice

Long Yun Kang, José Luis Gabriel, Kening Wu, José Antonio Rodríguez Martín et autres

Charge-dependent mitochondrial targeting of cerium-doped polypyrrole nanoparticles to injured renal tubules for acute kidney injury therapy

Mengjie Huang, Yuanqi Liu, Tuo Xiao, Peng Qi et autres

Acute kidney injury (AKI) is a critical medical condition with limited treatment options and frequently progresses to chronic kidney disease (CKD). This study introduces a novel nanotherapeutic approach based on positively charged cerium-doped polypyrrole nanoparticles [(+)CePPy] for AKI treatment. The positive surface …

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NIR-II Fluorescence Project Technology for Augmented Reality Surgical Navigation

Yuhuang Zhang, Xiaolong Liu, Z. Liu, Chao Liu et autres

NIR-II fluorescence imaging provides superior tissue penetration and clarity, yet its clinical use in surgical navigation is hindered by a critical workflow issue. Surgeons must divert their attention between the operative field and external monitors, increasing cognitive load and disrupting procedures. Current …

Engineering Metal‐Organic‐Framework‐Based STING Nanoagonists for PROTAC‐Enhanced Cancer Chemo‐Metalloimmunotherapy

Zhenzhen Chen, Zhe Feng, Siyuan Wang, Jingjing Zhang

Abstract Chemo‐metalloimmunotherapy is emerging as a promising strategy for cancer treatment by integrating chemotherapy‐induced immunogenicity with metal ion‐mediated immune activation. However, its efficacy is hampered by chemoresistance and immune escape driven by PD‐L1 upregulation. Here, a multifunctional manganese‐based metal‐organic framework nanoplatform (Mn‐CDDP‐dBET6@CM) …

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Germanium‐Based Long‐Conjugation Xanthene Fluorophores for Bioimaging in Optimal NIR‐II Sub‐Window

Jin Li, Qiming Xia, Jiayi Li, Xiaoming Yu et autres

ABSTRACT The near‐infrared‐IIx (NIR‐IIx, 1400–1500 nm) sub‐window theoretically surpasses the conventional near‐infrared‐II (NIR‐II) region in optical imaging fidelity but requires luminophores with high brightness and stability. Herein, we present a germanium‐engineered xanthene fluorophore (EGe5) featuring extended π‐conjugation and a planarized core, as …

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Single mode lasing and spectral narrowing in photonic crystal line-defect cavities via spatially selected Bloch modes

Lingfang Wang, Xiaotian Cheng, Jiawang Yu, Dai‐Bao Hou et autres

The demand for high-efficiency and miniaturized on-chip light sources drives continuous innovation in photonic crystal (PhC) microcavity lasers. The presence of slow-light effects in PhC microcavities leads to the mode competition between Bloch modes resulting in multi-mode lasing, which obstructs the dense …

us, cn (code pays fourni par la source)

Edwardsiella piscicida employs C3 derivative to mediate internalization and infection via the teleost-specific receptor

Mo-fei Li, Xiaoyan Jin, Heng Liu, Zhe Feng et autres

Edwardsiella piscicida is a prominent fish pathogen, and spreads the infection to humans and mammals. It can resist serum killing and invade the host phagocytic cells. However, the precise mechanisms underlying E. piscicida infection remain unclear. In this study, we found that …

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