Accès ouvert
2025
article
OpenAlex
Christopher Pagett, JOHN J. LILLEY, Christopher O’Hara, Ane Lindegaard Appelt et autres
Background and purpose: Reirradiation is clinically challenging, requiring a balance between delivery of dose to tumour while respecting cumulative organ at risk (OAR) dose constraints. Standard prescriptions are often conservative, ignoring patient variability in achievable OAR doses. Isotoxic radiotherapy individualises treatment by …
gb, se
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Ruth P. Newton, Emily Russell, Marcus Tyyger, Christopher O’Hara et autres
Abstract Background and purpose: Adaptive radiotherapy (ART) is commonly used to mitigate effects of anatomical change during head and neck (H&N) radiotherapy. The process of identifying patients for ART can be subjective and resource-intensive. This feasibility project aims to design and validate …
gb, se
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Meshal Alzahrani, Christopher O’Hara, D. J. Bird, Jack P.C. Baldwin et autres
Abstract Objective. This study aimed to optimise Cone Beam Computed Tomography (CBCT) protocols for head and neck (H&N) radiotherapy treatments using a 3D printed anthropomorphic phantom. It focused on precise patient positioning in conventional treatment and adaptive radiotherapy (ART). Approach. Ten CBCT …
gb, sa
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Andrea Lorenzo Polo, Michael G. Nix, Christopher M. Thompson, Christopher O’Hara et autres
Abstract Objective. Deformable image registration (DIR) is a widely used technique in radiotherapy. Complex deformations, resulting from large anatomical changes, are a regular challenge. DIR algorithms generally seek a balance between capturing large deformations and preserving a smooth deformation vector field (DVF). …
se, gb
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Emily Russell, Christopher O’Hara, Sebastian Andersson, Ann M. Henry et autres
Abstract Background and purpose: This project developed and validated an automated pipeline for prostate treatments to accurately determine which patients could benefit from adaptive radiotherapy (ART) using synthetic CTs (sCTs) generated from on-treatment cone-beam CT (CBCT) images. Materials and methods: The automated …
se, gb
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Christopher O’Hara, D. J. Bird, Bashar M. Al‐Qaisieh, Richard J. Speight
PURPOSE: Cone-beam CT (CBCT)-based synthetic CT (sCT) dose calculation has the potential to make the adaptive radiotherapy (ART) pathway more efficient while removing subjectivity. This study assessed four sCT generation methods using 15 head-and-neck rescanned ART patients. Each patient's planning CT (pCT), …
gb
(code pays fourni par la source)