Bernd Kupfer

Secondary structure of DNA released from purified capsids of human parvovirus B19 under moderate denaturing conditions

B. Matz, Bernd Kupfer, René Kallies, Manuel Külshammer et autres

Parvovirus B19 (B19V) possesses a linear single-stranded DNA genome of either positive or negative polarity. Due to intramolecular sequence homologies, either strand may theoretically be folded in several alternative ways. Viral DNA, when extracted from virions by several procedures, presents as linear …

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Bedeutung der RANTES-28 Promotormutation für den Spontanverlauf der HCV- und HCV/HIV-Koinfektion

Golo Ahlenstiel, Agathe Iwan, JK Rockstroh, H.H. Brackmann et autres

Hintergrund/Einleitung: Chemokine und ihre Rezeptoren nehmen eine zentrale Rolle bei der Regulation der Immunantwort auf eine HIV- oder HCV-Infektion ein. Die RANTES-Promotormutation RANTES-28 (C>>G) verändert die Transkription dieses Chemokins und könnte daher Einfluss auf den Spontanverlauf dieser Infektionen haben. Material und Methoden: …

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Auswirkung der HAART auf leberbezogene Sterberate in HIV/HCV koinfizierten Patienten

N. Qurishi, Christina Kreuzberg, Wolfgang Effenberger, Guido Lüchters et autres

Hintergrund: Die Hepatitis C ist bei Patienten mit gleichzeitiger HIV-Infektion durch eine deutlich schnellere Progression zu Fibrose, Zirrhose mit Dekompensation und hepatozellulärem Karzinom gekennzeichnet. Das Risiko an einer leberbedingten Komplikation zu versterben, ist bei HIV/HCV-koinfizierten Patienten deutlich höher als bei HCV monoinfizierten …

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Does hepatitis C viremia or genotype predict the risk of mortality in individuals co-infected with HIV?

Jürgen Kurt Rockstroh, Lars Peters, Daniel J. Grint, Vincent Soriano et autres

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An International Collaboration To Standardize HIV-2 Viral Load Assays: Results from the 2009 ACHI E V 2E Quality Control Study

Florence Damond, Antoine Bénard, Claudia Balotta, Jürg Böni et autres

Accurate HIV-2 plasma viral load quantification is crucial for adequate HIV-2 patient management and for the proper conduct of clinical trials and international cohort collaborations. This study compared the homogeneity of HIV-2 RNA quantification when using HIV-2 assays from ACHI(E)V(2E) study sites …

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Interferon-lambda serum levels in hepatitis C

Bettina Langhans, Bernd Kupfer, Ingrid Braunschweiger, Simone Arndt et autres

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Influence of Extraction Protocol on Physical Properties of Parvovirus B19 DNA

B. Matz, Bernd Kupfer, Thomas R. Kreil, Anna Maria Eis‐Hübinger

While establishing a quantification standard for parvovirus B19 diagnostics, we extracted viral DNA from a high-titered human plasma by using three commercial kits. Despite similar viral DNA yields being obtained, striking differences in electrophoretic mobilities of the extracted nucleic acids were observed.

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Characterisation of the epitope for a herpes simplex virus glycoprotein B-specific monoclonal antibody with high protective capacity

Martin Däumer, Beate Schneider, Doris M. Giesen, Sheriff Aziz et autres

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Phylogenetic analysis of acute hepatitis C virus genotype 4 infections among human immunodeficiency virus-positive men who have sex with men in Germany

Martin Vogel, Thijs van de Laar, Bernd Kupfer, Hans‐Jürgen Stellbrink et autres

BACKGROUND: An ongoing HCV epidemic currently affects a growing proportion of HIV-positive men who have sex with men (MSM) in Europe. Recently in the North-Rhine region of Germany, we have observed an increase in acute HCV infections of genotype 4 (HCV-4). AIMS: …

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GB virus C coinfection in advanced HIV type-1 disease is associated with low CCR5 and CXCR4 surface expression on CD4 + T-cells

Carolynne Schwarze‐Zander, Markus Neibecker, Cristina Tural, Bonaventura Clotet et autres

BACKGROUND: Coinfection with the flavivirus GB virus C (GBV-C) is frequent in patients suffering from HIV type-1 (HIV-1) infection because of shared routes of transmission. GBV-C coinfection has been proposed to exert a beneficial influence on HIV-1 infection. In vitro studies demonstrated …

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Detection of All Species of the Genus Alphavirus by Reverse Transcription-PCR with Diagnostic Sensitivity

Klaus Grywna, Bernd Kupfer, Marcus Panning, Jan Felix Drexler et autres

Clinical arbovirus screening requires exclusion of a broad range of viruses with as few assays as possible. We present a reverse transcription-PCR (RT-PCR) for the detection of all species of the genus Alphavirus qualified for exclusion screening (limit of detection [LOD], 5 …

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Frequent hepatitis B virus rebound among HIV–hepatitis B virus-coinfected patients following antiretroviral therapy interruption

Gregory J. Dore, Jürgen Kurt Rockstroh, Bernd Kupfer, Ellen Tedaldi et autres

BACKGROUND: The impact of antiretroviral therapy (ART) interruption in HIV-hepatitis B virus (HBV)-coinfected patients was examined in the Strategic Management of AntiRetroviral Therapy (SMART) study. METHODS: Plasma HBV DNA was measured in all hepatitis B surface antigen-positive (HBV-positive) participants at baseline, and …

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