Gut microbiome features co‐occur in different groups of Alzheimer’s disease phenotypes and genotypes
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Le résumé fourni par la source
Abstract Background Gut microbiome features are known to be different in Alzheimer’s disease (AD) patients compared with cognitively normal. Evidence suggests that the gut microbiota may be related to the pathology of AD. We examined the association between the gut microbiome and AD phenotypes and genotypes. Method Cross‐sectional analysis was performed on the filtered microbiome count table including 246 participants from the Microbiome in AD Risk Study. The filtered taxonomic count table was used to analyze differential abundance using the BIRDMAn pipeline. To determine the differences in the microbiota features derived from each cognitive, amyloid, and ApoE4 group, we implemented statistical models that had microbiome features as outcome variables and each cognitive, amyloid, and ApoE4 group as predictor variable adjusting for covariates including age, sex, BMI, Bristol type, and age difference between fecal collection and measurements of each predictor variable. Result Each cognitive, amyloid, and ApoE4 group showed differentially abundant microbiota features. Top microbial features (more abundant in AD, amyloid +, ApoE4 +) that co‐occurred with all three groups were mostly Bacteroides spp., Collinsella spp., and Fusobacterium spp. Bottom microbial features (less abundant in AD, amyloid +, ApoE4 +) that co‐occurred with all three groups were mostly Dialister spp. and Prevotella spp. Conclusion The same microbial species were more abundant and less abundant in clinical, preclinical, and genetic risk groups. These results suggest candidate microbes that can be stratified in analyses that involve associations between gut microbiome and AD pathology.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Gut microbiome features co‐occur in different groups of Alzheimer’s disease phenotypes and genotypes
- Date Crossref
- 01/12/2024
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Wisconsin–Madison pays non établi dans la noticeUniversité ou école supérieure
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University of California San Diego pays non établi dans la noticeUniversité ou école supérieure
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Duke University Department of Psychiatry and Behavioral Sciences pays non établi dans la noticeUniversité ou école supérieure
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University of Wisconsin School of Medicine and Public Health Wisconsin Alzheimer's Disease Research Center pays non établi dans la noticeUniversité ou école supérieure
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University of Wisconsin‐Madison Department of Pathology and Laboratory Medicine pays non établi dans la noticeUniversité ou école supérieure
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Wisconsin Alzheimer's Disease Research Center pays non établi dans la noticeStructure de recherche
University of Wisconsin–Madison, University of California San Diego et Department of Psychiatry and Behavioral Sciences — Duke University, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.